DK1516629T3 - Humaniseret anti-CD-11a antibodies - Google Patents
Humaniseret anti-CD-11a antibodiesInfo
- Publication number
- DK1516629T3 DK1516629T3 DK04004941.3T DK04004941T DK1516629T3 DK 1516629 T3 DK1516629 T3 DK 1516629T3 DK 04004941 T DK04004941 T DK 04004941T DK 1516629 T3 DK1516629 T3 DK 1516629T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies
- humanized anti
- humanized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75720596A | 1996-11-27 | 1996-11-27 | |
| EP97912841A EP0941344B1 (en) | 1996-11-27 | 1997-10-20 | HUMANIZED ANTI-CD11a ANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1516629T3 true DK1516629T3 (da) | 2013-06-03 |
Family
ID=25046834
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04004941.3T DK1516629T3 (da) | 1996-11-27 | 1997-10-20 | Humaniseret anti-CD-11a antibodies |
| DK97912841T DK0941344T3 (da) | 1996-11-27 | 1997-10-20 | Humaniserede anti-CD11a-antistoffer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97912841T DK0941344T3 (da) | 1996-11-27 | 1997-10-20 | Humaniserede anti-CD11a-antistoffer |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP1516629B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP3778945B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR100532178B1 (cg-RX-API-DMAC10.html) |
| AR (1) | AR008919A1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE267257T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU731817C (cg-RX-API-DMAC10.html) |
| CA (1) | CA2272842C (cg-RX-API-DMAC10.html) |
| DE (3) | DE69729209T2 (cg-RX-API-DMAC10.html) |
| DK (2) | DK1516629T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2221045T3 (cg-RX-API-DMAC10.html) |
| FR (1) | FR04C0028I2 (cg-RX-API-DMAC10.html) |
| IL (3) | IL130143A0 (cg-RX-API-DMAC10.html) |
| LU (1) | LU91122I2 (cg-RX-API-DMAC10.html) |
| NL (1) | NL300163I2 (cg-RX-API-DMAC10.html) |
| PT (1) | PT941344E (cg-RX-API-DMAC10.html) |
| WO (1) | WO1998023761A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA979599B (cg-RX-API-DMAC10.html) |
Families Citing this family (74)
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|---|---|---|---|---|
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| SI1135498T1 (sl) | 1998-11-18 | 2008-06-30 | Genentech Inc | Variante protitelesa z višjo vezavno afiniteto vprimerjavi z izvirnimi protitelesi |
| EP1135498B1 (en) | 1998-11-18 | 2008-01-23 | Genentech, Inc. | Antibody variants with higher binding affinity compared to parent antibodies |
| ES2331643T3 (es) * | 1999-03-19 | 2010-01-12 | Genentech, Inc. | Tratamiento de trastornos asociados con lfa-1 con dosis crecientes de antagonista de lfa-1. |
| US6582698B1 (en) | 1999-03-19 | 2003-06-24 | Genentech, Inc. | Treatment method |
| US20010031260A1 (en) * | 1999-12-14 | 2001-10-18 | Genentech, Inc. | Treatment method |
| US7575921B2 (en) | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| US7560275B2 (en) | 1999-12-30 | 2009-07-14 | Vbi Technologies, L.L.C. | Compositions and methods for generating skin |
| AU2001230920A1 (en) * | 2000-01-14 | 2001-07-24 | Genentech Inc. | Diagnosis and treatment of hepatic inflammatory disorders by inhibiting the binding of lfa-1 to icam-1 |
| US7160541B2 (en) * | 2000-09-01 | 2007-01-09 | The Center For Blood Research, Inc. | Modified polypeptides stabilized in a desired conformation and methods for producing same |
| WO2002057428A1 (en) | 2000-10-30 | 2002-07-25 | University Of Massachusetts | Isolation of spore-like cells from tissues exposed to extreme conditions |
| EP2048154B2 (en) | 2002-02-05 | 2015-06-03 | Genentech, Inc. | Protein purification |
| JP4319979B2 (ja) | 2002-04-26 | 2009-08-26 | ジェネンテック・インコーポレーテッド | タンパク質の非アフィニティ精製 |
| EP1539228B1 (en) | 2002-09-11 | 2010-12-29 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| EP2404615A1 (en) * | 2003-04-23 | 2012-01-11 | Medarex, Inc. | Humanized antibodies to interferon alpha receptor-1 (IFNAR-1) |
| US7485704B2 (en) | 2003-07-28 | 2009-02-03 | Genentech, Inc. | Reducing protein A leaching during protein A affinity chromatography |
| CA2554965C (en) | 2004-02-19 | 2015-08-11 | The Cbr Institute For Biomedical Research, Inc. | Antibodies specific for activated conformation of lfa-1 |
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| MXPA06014354A (es) * | 2004-06-09 | 2007-02-19 | Genentech Inc | Metodo para tratar granuloma anular o sarcoide. |
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| US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
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| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
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| NZ577933A (en) | 2007-01-22 | 2011-12-22 | Genentech Inc | Polyelectrolyte precipitation and purification of antibodies |
| PT3327026T (pt) | 2007-07-09 | 2019-10-30 | Genentech Inc | Prevenção da redução de ligações de dissulfureto durante a produção recombinante de polipéptidos |
| MX2010004740A (es) | 2007-10-30 | 2010-05-27 | Genentech Inc | Purificacion de anticuerpos por cromatografia de intercambio cationico. |
| HUE036780T2 (hu) * | 2008-04-09 | 2018-07-30 | Genentech Inc | Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére |
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| EP2145901B1 (en) | 2008-07-18 | 2012-11-14 | Technische Universität Braunschweig | Recombinant anti-MUC1 antibodies |
| FI3604324T3 (fi) | 2008-08-14 | 2024-05-16 | Genentech Inc | Menetelmiä epäpuhtauden poistamiseksi käyttäen luontaisen proteiinin syrjäytyksen ioninvaihtomembraanikromatografiaa |
| EP2684570A1 (en) | 2008-09-10 | 2014-01-15 | F. Hoffmann-La Roche AG | Compositions and methods for the prevention of oxidative degradation of proteins |
| CN102256993A (zh) | 2008-12-16 | 2011-11-23 | 米利波尔公司 | 蛋白的纯化 |
| DK2370561T3 (da) | 2008-12-16 | 2019-10-21 | Emd Millipore Corp | Omrøringstankreaktor og fremgangsmåde |
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| FI2464725T4 (fi) | 2009-08-11 | 2025-03-21 | Hoffmann La Roche | Proteiinien tuotanto glutamiinittomassa soluviljelyn elatusaineessa |
| EP3736338A1 (en) | 2009-09-01 | 2020-11-11 | F. Hoffmann-La Roche AG | Enhanced protein purification through a modified protein a elution |
| CA2780549C (en) | 2009-11-12 | 2017-01-03 | Vbi Technologies, L.L.C. | Subpopulations of spore-like cells and uses thereof |
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| ES2880802T3 (es) | 2010-06-24 | 2021-11-25 | Hoffmann La Roche | Composiciones y procedimientos para estabilizar formulaciones que contienen proteínas |
| KR20130100125A (ko) | 2010-08-13 | 2013-09-09 | 제넨테크, 인크. | 질환의 치료를 위한, ＩＬ-1β 및 ＩＬ-18에 대한 항체 |
| WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| US9814740B2 (en) * | 2010-12-21 | 2017-11-14 | Duke University | Methods and compositions combining immunotherapy with monocyte activation |
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| CA2859376C (en) | 2011-12-22 | 2022-04-19 | Genentech, Inc. | Use of ion exchange chromatography for improving downstream chromatography steps for purification of antibodies |
| CA2866753C (en) | 2012-03-27 | 2020-09-22 | Genentech, Inc. | Improved harvest operations for recombinant proteins |
| PL3427721T3 (pl) | 2012-05-18 | 2025-07-14 | Genentech, Inc. | Formulacje o wysokim stężeniu przeciwciał monoklonalnych |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ236792A (en) * | 1990-01-19 | 1993-05-26 | Merck & Co Inc | Recombinant human anti-cd18 antibody, murine 1b4 heavy or light chain variable region, dna, vectors, mammalian host and pharmaceutical compositions |
| US6096871A (en) * | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
-
1997
- 1997-10-20 IL IL13014397A patent/IL130143A0/xx active IP Right Grant
- 1997-10-20 PT PT97912841T patent/PT941344E/pt unknown
- 1997-10-20 DE DE69729209T patent/DE69729209T2/de not_active Expired - Lifetime
- 1997-10-20 KR KR10-1999-7004671A patent/KR100532178B1/ko not_active Expired - Lifetime
- 1997-10-20 AU AU49929/97A patent/AU731817C/en not_active Expired
- 1997-10-20 JP JP52464598A patent/JP3778945B2/ja not_active Expired - Lifetime
- 1997-10-20 AT AT97912841T patent/ATE267257T1/de active
- 1997-10-20 DE DE1997629209 patent/DE122004000047I2/de active Active
- 1997-10-20 WO PCT/US1997/019041 patent/WO1998023761A1/en not_active Ceased
- 1997-10-20 DE DE200412000047 patent/DE122004000047I1/de active Pending
- 1997-10-20 DK DK04004941.3T patent/DK1516629T3/da active
- 1997-10-20 EP EP04004941A patent/EP1516629B1/en not_active Expired - Lifetime
- 1997-10-20 EP EP97912841A patent/EP0941344B1/en not_active Expired - Lifetime
- 1997-10-20 CA CA2272842A patent/CA2272842C/en not_active Expired - Lifetime
- 1997-10-20 ES ES97912841T patent/ES2221045T3/es not_active Expired - Lifetime
- 1997-10-20 DK DK97912841T patent/DK0941344T3/da active
- 1997-10-27 ZA ZA979599A patent/ZA979599B/xx unknown
- 1997-11-04 AR ARP970105146A patent/AR008919A1/es active IP Right Grant
-
1999
- 1999-05-26 IL IL130143A patent/IL130143A/en not_active IP Right Cessation
-
2004
- 2004-11-10 LU LU91122C patent/LU91122I2/fr unknown
- 2004-11-12 NL NL300163C patent/NL300163I2/nl unknown
- 2004-12-10 FR FR04C0028C patent/FR04C0028I2/fr active Active
-
2005
- 2005-08-02 JP JP2005224609A patent/JP4309383B2/ja not_active Expired - Lifetime
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2006
- 2006-05-11 IL IL175583A patent/IL175583A0/en not_active IP Right Cessation
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