DK1503984T3 - 8-azaprostaglandin-analoger som midler til sænkning af intraokulært tryk - Google Patents

8-azaprostaglandin-analoger som midler til sænkning af intraokulært tryk

Info

Publication number
DK1503984T3
DK1503984T3 DK03724322.7T DK03724322T DK1503984T3 DK 1503984 T3 DK1503984 T3 DK 1503984T3 DK 03724322 T DK03724322 T DK 03724322T DK 1503984 T3 DK1503984 T3 DK 1503984T3
Authority
DK
Denmark
Prior art keywords
azaprostaglandin
analogues
agents
intraocular pressure
lowering intraocular
Prior art date
Application number
DK03724322.7T
Other languages
English (en)
Inventor
David W Old
Danny Thang Dinh
Robert M Burk
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DK1503984T3 publication Critical patent/DK1503984T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DK03724322.7T 2002-05-14 2003-04-28 8-azaprostaglandin-analoger som midler til sænkning af intraokulært tryk DK1503984T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/146,224 US6573294B1 (en) 2002-05-14 2002-05-14 8-azaprostaglandin analogs as agents for lowering intraocular pressure
PCT/US2003/013300 WO2003097596A1 (en) 2002-05-14 2003-04-28 8-azaprostaglandin analogs as agents for lowering intraocular pressure

Publications (1)

Publication Number Publication Date
DK1503984T3 true DK1503984T3 (da) 2013-05-27

Family

ID=22516366

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03724322.7T DK1503984T3 (da) 2002-05-14 2003-04-28 8-azaprostaglandin-analoger som midler til sænkning af intraokulært tryk

Country Status (13)

Country Link
US (3) US6573294B1 (da)
EP (1) EP1503984B1 (da)
JP (3) JP2005530796A (da)
KR (1) KR20050000531A (da)
CN (1) CN1313447C (da)
AU (2) AU2003231188A1 (da)
BR (1) BR0310047A (da)
CA (1) CA2485850C (da)
DK (1) DK1503984T3 (da)
ES (1) ES2402764T3 (da)
HK (1) HK1072603A1 (da)
MX (1) MXPA04011213A (da)
WO (1) WO2003097596A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ513825A (en) 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
EP1339678B1 (en) * 2000-11-27 2007-09-26 Pfizer Products Inc. Ep4 receptor selective agonists in the treatment of osteoporosis
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
WO2003047513A2 (en) * 2001-12-03 2003-06-12 Merck & Co., Inc. Method for treating ocular hypertension
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
US7256211B1 (en) 2003-01-21 2007-08-14 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivatives and medical use thereof
US6734201B1 (en) * 2003-06-02 2004-05-11 Allergan, Inc. 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
WO2005121086A2 (en) 2004-06-04 2005-12-22 Allergan, Inc. Piperidinyl prostaglandin analogs as ocular hypotensive agents
JP2008517941A (ja) * 2004-10-21 2008-05-29 デューク・ユニバーシティー 眼科用薬剤
AU2012211448B2 (en) * 2005-03-10 2016-01-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
EP1856042B1 (en) 2005-03-10 2012-06-27 Allergan, Inc. Substituted gamma lactams as therapeutic agents
US7592364B2 (en) * 2006-02-28 2009-09-22 Allergan, Inc. Substituted gamma lactams as therapeutic agents
EP1996546B1 (en) * 2006-03-20 2014-11-26 Allergan, Inc. Substituted gamma lactams as prostaglandin ep2 agonists
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US7553860B2 (en) * 2006-06-14 2009-06-30 Allergan, Inc. Substituted gamma lactams as therapeutic agents
DE602007013412D1 (de) * 2006-08-09 2011-05-05 Allergan Inc Therapeutische amide und entsprechende verbindungen
EP2121672B1 (en) * 2007-01-31 2014-12-10 Allergan, Inc. Substituted gamma lactams as therapeutic agents
CA2678191A1 (en) * 2007-02-15 2008-08-21 Allergan, Inc. Gamma-lactams for the treatment of glaucoma or elevated intraocular pressure
US7956055B2 (en) * 2008-03-25 2011-06-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
MX2010011636A (es) * 2008-04-24 2010-11-25 Allergan Inc Gamma lactamas sustituidas como agentes terapeuticos.
US7985765B2 (en) * 2008-08-20 2011-07-26 Allergan, Inc. Therapeutic substituted pyrroles
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
WO2012024072A1 (en) * 2010-08-19 2012-02-23 Allergan, Inc. Compositions comprising adipose tissue and a pge2 analogue and their use in the treatment of a soft tissue condition
JP6141430B2 (ja) 2012-07-19 2017-06-07 ケイマン ケミカル カンパニー， インコーポレーテッド Ｅｐ４介在性骨関連疾患及び病態用ジフルオロラクタム組成物
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
KR20150130326A (ko) 2013-03-15 2015-11-23 카이맨 케미칼 컴파니 인코포레이티드 Ep4-매개 질환 및 병태의 치료에서 사용하기 위한 ep4 수용체 선택적 효현제로서 락탐 화합물
AU2014290512A1 (en) 2013-07-19 2015-11-12 Cayman Chemical Company, Inc. Methods, systems, and compositions for promoting bone growth
AU2015233046A1 (en) 2014-03-18 2016-11-03 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2528664A1 (de) * 1975-06-27 1977-01-13 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
SE423813B (sv) * 1976-08-06 1982-06-07 Pfizer Forfarande for framstellning av 1,5-disubstituerade pyrrolidoner med terapeutiska egenskaper
US4177346A (en) * 1976-08-06 1979-12-04 Pfizer Inc. 1,5-Disubstituted-2-pyrrolidones
US5034413A (en) 1989-07-27 1991-07-23 Allergan, Inc. Intraocular pressure reducing 9,11-diacyl prostaglandins
US5028624A (en) 1989-07-27 1991-07-02 Allergan, Inc. Intraocular pressure reducing 9,15-diacyl prostaglandins
CA2021316C (en) 1989-07-27 2000-10-24 Ming Fai Chan Intraocular pressure reducing 11-acyl prostaglandins
US4994274A (en) 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
JP2000095755A (ja) * 1998-07-21 2000-04-04 Ono Pharmaceut Co Ltd ω―シクロアルキル―プロスタグランジンＥ１誘導体、その製造方法およびその誘導体を有効成分とする医薬組成物
AU2211700A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Prostaglandin e agonists for treatment of glaucoma
AP2001002357A0 (en) 1999-12-22 2001-12-31 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis.
PT1132086E (pt) 2000-01-31 2006-09-29 Pfizer Prod Inc Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica
US20010056060A1 (en) * 2000-02-07 2001-12-27 Cameron Kimberly O. Treatment of osteoporsis with EP2/EP4 receptor selective agonists
AU2001290250A1 (en) 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
EP1339678B1 (en) 2000-11-27 2007-09-26 Pfizer Products Inc. Ep4 receptor selective agonists in the treatment of osteoporosis
AU2002328855B2 (en) 2001-07-16 2005-11-24 F. Hoffmann-La Roche Ag Prostaglandin Analogues As EP4 Receptor Agonists
DK1408961T3 (da) 2001-07-16 2007-11-05 Hoffmann La Roche 2 pyrrolidon-derivater som prostanoide agonister
IL159996A0 (en) 2001-07-23 2004-06-20 Ono Pharmaceutical Co Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient
WO2003047513A2 (en) * 2001-12-03 2003-06-12 Merck & Co., Inc. Method for treating ocular hypertension
ES2268327T3 (es) * 2002-03-18 2007-03-16 Pfizer Products Inc. Uso de un selectivo de un receptor de ep4 para el tratamiento de enfermedades.
JP2005526080A (ja) * 2002-03-18 2005-09-02 ファイザー・プロダクツ・インク 肝不全、動脈管閉鎖、緑内障又は高眼圧の治療のための選択的ｅｐ４受容体アゴニストの使用
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure

Also Published As

Publication number Publication date
CA2485850C (en) 2012-07-03
BR0310047A (pt) 2005-02-15
US20030220506A1 (en) 2003-11-27
EP1503984B1 (en) 2013-03-20
JP2014122250A (ja) 2014-07-03
US6573294B1 (en) 2003-06-03
AU2010201226A1 (en) 2010-04-22
US6906097B2 (en) 2005-06-14
CN1313447C (zh) 2007-05-02
AU2003231188A1 (en) 2003-12-02
EP1503984A1 (en) 2005-02-09
KR20050000531A (ko) 2005-01-05
JP2005530796A (ja) 2005-10-13
ES2402764T3 (es) 2013-05-08
WO2003097596A1 (en) 2003-11-27
US20040157912A1 (en) 2004-08-12
CA2485850A1 (en) 2003-11-27
CN1653045A (zh) 2005-08-10
MXPA04011213A (es) 2005-02-14
JP2011116768A (ja) 2011-06-16
HK1072603A1 (en) 2005-09-02

Similar Documents

Publication Publication Date Title
DK1503984T3 (da) 8-azaprostaglandin-analoger som midler til sænkning af intraokulært tryk
DK2263674T3 (da) 10,10-Dialkyl-prostansyrederivater som midler til sænkning af intraokulært tryk
NO20044654L (no) Piperidinoylpiperidiner som 5-HTIF-agonister
DK1575416T3 (da) Fremgangsmåder til diagnosticering af præeklampsi
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1504126T3 (da) Fremgangsmåde til regulering af genekspression
NO20044174L (no) Kumariner som er nyttige som biomarkorer
NO20052884D0 (no) Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
DK1789041T3 (da) Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK1638928T3 (da) N-alkynyl-2-(substituerede aryloxy)alkylthio-amidderivater som fungicider
DK1797042T3 (da) Indozolonderivater som 11B-HSD1-inhibitorer
NO20050665L (no) Pyrrolidonderivater som MAOE inhibitoere
NO20053775D0 (no) Diazepinoindol derivater som kinaseinhibitorer.
DK1487806T3 (da) 4-anilin-quinazolinderivater som antiproliferative midler
DK1423391T3 (da) Pyrrolopyrimidiner som midler til inhibering af cysteinproteaser
NO20051688D0 (no) Farmasoytiske blandinger som har en modifisert baerer
NO20052921D0 (no) Fenylsubstituerte piperidinforbindelser for anvendelse som PPAR aktivatorer
DK1501826T3 (da) Substituerede indoler som alpha-1-agonister
NO20054775D0 (no) Biaryl-substituerte triazoler som natriumkanalblokkere
NO20054669D0 (no) Substituerte kinobenzoxazinanaloger
NO20033618D0 (no) Ftalayinon-piperidino-derivater som PDE-4-inhibitorer
DK1660090T3 (da) Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
DE60335913D1 (de) Ghrelin-analoga
DK1536685T3 (da) Fremgangsmåde til fremstilling af pasta-ekstruderede sulfonamidsammensætninger
NO20043794L (no) Benzensulfonamidderivater som antipsykotiske midler