DK147261C - Analogifremgangsmaade til fremstilling af mono(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r-cis)-(3-methyloxiranyl)phosphonat - Google Patents

Analogifremgangsmaade til fremstilling af mono(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r-cis)-(3-methyloxiranyl)phosphonat

Info

Publication number
DK147261C
DK147261C DK442080A DK442080A DK147261C DK 147261 C DK147261 C DK 147261C DK 442080 A DK442080 A DK 442080A DK 442080 A DK442080 A DK 442080A DK 147261 C DK147261 C DK 147261C
Authority
DK
Denmark
Prior art keywords
methyloxiranyl
phosphonate
hydroxymethyl
cis
ammonium
Prior art date
Application number
DK442080A
Other languages
Danish (da)
English (en)
Other versions
DK147261B (da
DK442080A (da
Inventor
Dario Chiarino
Davide Della Bella
Vittorio Ferrari
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of DK442080A publication Critical patent/DK442080A/da
Publication of DK147261B publication Critical patent/DK147261B/da
Application granted granted Critical
Publication of DK147261C publication Critical patent/DK147261C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505Phosphonic acids containing oxirane groups; esters thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
DK442080A 1979-10-18 1980-10-17 Analogifremgangsmaade til fremstilling af mono(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r-cis)-(3-methyloxiranyl)phosphonat DK147261C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT26581/79A IT1124610B (it) 1979-10-18 1979-10-18 Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato
IT2658179 1979-10-18

Publications (3)

Publication Number Publication Date
DK442080A DK442080A (da) 1981-04-19
DK147261B DK147261B (da) 1984-05-28
DK147261C true DK147261C (da) 1984-11-26

Family

ID=11219823

Family Applications (1)

Application Number Title Priority Date Filing Date
DK442080A DK147261C (da) 1979-10-18 1980-10-17 Analogifremgangsmaade til fremstilling af mono(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r-cis)-(3-methyloxiranyl)phosphonat

Country Status (23)

Country Link
US (1) US4863908A (bg)
EP (1) EP0027597B1 (bg)
JP (1) JPS5677290A (bg)
AT (1) ATE2005T1 (bg)
AU (1) AU532089B2 (bg)
BE (1) BE885756A (bg)
BG (1) BG61368B2 (bg)
CA (1) CA1163274A (bg)
CH (1) CH644613A5 (bg)
DE (1) DE3061359D1 (bg)
DK (1) DK147261C (bg)
ES (1) ES495870A0 (bg)
FR (1) FR2467856A1 (bg)
GB (1) GB2062640B (bg)
GR (1) GR70312B (bg)
IE (1) IE50319B1 (bg)
IL (1) IL61221A (bg)
IT (1) IT1124610B (bg)
LU (1) LU88335I2 (bg)
MX (1) MX9203181A (bg)
NL (1) NL930041I2 (bg)
YU (1) YU41742B (bg)
ZA (1) ZA806308B (bg)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136652B (it) * 1981-06-04 1986-09-03 Crinos Industria Farmaco Compesizione farmaceutica di fosfomicina in compresse da succhiare
CH660305A5 (de) * 1984-10-05 1987-04-15 Schering Spa Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
US5191094A (en) * 1989-07-27 1993-03-02 Zambon Group S.P.A. Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing
IT1231013B (it) * 1989-07-27 1991-11-08 Zambon Spa Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'.
ITMI20021725A1 (it) 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
ES2244333B1 (es) * 2004-05-18 2006-08-01 Simbec Iberica, Sl Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos.
EP1762573A1 (en) 2005-09-08 2007-03-14 Interquim, S.A. De C.V. A process for the preparation of fosfomycin salts
ES2345591B1 (es) * 2009-03-10 2011-07-21 Labiana Pharmaceuticals, S.L. Procedimiento para la preparacion de fosfomicina trometamol.
CN102351902A (zh) * 2011-08-12 2012-02-15 山西仟源制药股份有限公司 磷霉素单氨丁三醇的制备方法
CN102807586B (zh) 2012-08-31 2015-05-13 东北制药集团股份有限公司 磷霉素氨盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322767A (en) * 1963-06-03 1967-05-30 Gabriel G Nabas Tham salts
US3639590A (en) * 1967-07-25 1972-02-01 Merck & Co Inc Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid
US3641063A (en) * 1968-01-22 1972-02-08 Merck & Co Inc Antibiotic purification process
US3914231A (en) * 1970-09-04 1975-10-21 Merck & Co Inc ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof
US3940483A (en) * 1971-02-05 1976-02-24 E. R. Squibb & Sons, Inc. Antibiotic compositions and method
DE2134672A1 (de) * 1971-07-08 1973-01-25 Josef Dipl Chem Dr Rer N Klosa Wasserloesliches acetylsalicylsaeuresalz, dessen herstellung, zubereitung und anwendung
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
GB2158828B (en) * 1984-04-25 1987-12-09 Espanola De La Penicilina Y An Salts of fosfomycin

Also Published As

Publication number Publication date
ES8200700A1 (es) 1981-11-16
EP0027597B1 (en) 1982-12-15
EP0027597A1 (en) 1981-04-29
IE50319B1 (en) 1986-04-02
DE3061359D1 (en) 1983-01-20
ATE2005T1 (de) 1982-12-15
BG61368B2 (bg) 1997-06-30
DK147261B (da) 1984-05-28
US4863908A (en) 1989-09-05
IT1124610B (it) 1986-05-07
JPS6317836B2 (bg) 1988-04-15
FR2467856B1 (bg) 1984-10-05
CH644613A5 (it) 1984-08-15
MX9203181A (es) 1992-07-01
ZA806308B (en) 1981-08-26
IT7926581A0 (it) 1979-10-18
DK442080A (da) 1981-04-19
JPS5677290A (en) 1981-06-25
NL930041I2 (nl) 1993-11-16
YU41742B (en) 1987-12-31
YU266880A (en) 1983-06-30
AU6341880A (en) 1981-04-30
BE885756A (fr) 1981-04-16
GB2062640B (en) 1983-09-14
IL61221A (en) 1985-02-28
NL930041I1 (nl) 1993-08-02
AU532089B2 (en) 1983-09-15
GR70312B (bg) 1982-09-09
CA1163274A (en) 1984-03-06
IL61221A0 (en) 1980-12-31
FR2467856A1 (fr) 1981-04-30
ES495870A0 (es) 1981-11-16
IE802062L (en) 1981-04-18
LU88335I2 (fr) 1994-05-04
GB2062640A (en) 1981-05-28

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PUP Patent expired