DK1453858T3 - Fremgangsmåde til renaturering af rekombinante, disulfid-holdige proteiner ved høje proteinkoncentrationer i nærvær af aminer - Google Patents
Fremgangsmåde til renaturering af rekombinante, disulfid-holdige proteiner ved høje proteinkoncentrationer i nærvær af aminerInfo
- Publication number
- DK1453858T3 DK1453858T3 DK02774777.3T DK02774777T DK1453858T3 DK 1453858 T3 DK1453858 T3 DK 1453858T3 DK 02774777 T DK02774777 T DK 02774777T DK 1453858 T3 DK1453858 T3 DK 1453858T3
- Authority
- DK
- Denmark
- Prior art keywords
- renaturation
- amines
- high protein
- protein concentrations
- containing proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01127373A EP1314739A1 (en) | 2001-11-22 | 2001-11-22 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines |
| PCT/EP2002/012607 WO2003044055A1 (en) | 2001-11-22 | 2002-11-12 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1453858T3 true DK1453858T3 (da) | 2011-05-09 |
Family
ID=8179272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02774777.3T DK1453858T3 (da) | 2001-11-22 | 2002-11-12 | Fremgangsmåde til renaturering af rekombinante, disulfid-holdige proteiner ved høje proteinkoncentrationer i nærvær af aminer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7893210B2 (da) |
| EP (2) | EP1314739A1 (da) |
| JP (1) | JP4348188B2 (da) |
| KR (1) | KR100944845B1 (da) |
| AT (1) | ATE495191T1 (da) |
| AU (1) | AU2002340510A1 (da) |
| CY (1) | CY1112209T1 (da) |
| DE (1) | DE60238938D1 (da) |
| DK (1) | DK1453858T3 (da) |
| ES (1) | ES2357888T3 (da) |
| PT (1) | PT1453858E (da) |
| WO (1) | WO2003044055A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| AU2005277227B2 (en) * | 2004-08-19 | 2011-10-06 | Biogen Ma Inc. | Refolding transforming growth factor beta family proteins |
| TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| JP4984983B2 (ja) * | 2007-03-09 | 2012-07-25 | 富士通株式会社 | 符号化装置および符号化方法 |
| JP5583005B2 (ja) | 2007-05-01 | 2014-09-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 血管新生を増大させるための組成物および方法 |
| WO2016081289A1 (en) * | 2014-11-18 | 2016-05-26 | Merck Sharp & Dohme Corp. | Process for producing recombinant trypsin |
| CN113322222A (zh) * | 2021-07-02 | 2021-08-31 | 江苏恒丰强生物技术有限公司 | 一种表达猫ω干扰素的基因工程菌的生产工艺 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453363A (en) * | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
| AU2257488A (en) * | 1987-07-29 | 1989-03-01 | Schering Biotech Corporation | Purification of human interleukin-4 expressed in escherichia coli |
| WO1993003134A1 (en) * | 1991-07-29 | 1993-02-18 | Immunex Corporation | Process for isolating and purifying recombinant interleukin-7 |
| DE4137333A1 (de) * | 1991-11-13 | 1993-05-19 | W Prof Dr Sebald | Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung |
| US5407810A (en) * | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| EP0707074B1 (en) * | 1994-10-13 | 2000-01-19 | Kyowa Medex Co., Ltd. | Method for determination of urea nitrogen |
| US5563057A (en) * | 1994-10-31 | 1996-10-08 | Wisconsin Alumni Research Foundation | Method for refolding misfolded enzymes with detergent and cyclodextrin |
| US5728804A (en) * | 1995-06-02 | 1998-03-17 | Research Corporation Technologies, Inc. | Use of cyclodextrins for protein renaturation |
| PT1602667E (pt) * | 1995-06-07 | 2007-07-13 | Searle Llc | Formulação aquosa que compreende tfpi e agentes de solubilização |
| AU5195098A (en) * | 1996-11-06 | 1998-05-29 | Schering Corporation | Renaturation and purification of viral interleukin-10 (vil-10) |
| US20020052026A1 (en) * | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
| KR100253916B1 (ko) * | 1997-12-29 | 2000-05-01 | 김충환 | 사람 인슐린 전구체의 제조방법 |
| EP1022339B1 (en) | 1999-01-20 | 2006-02-01 | Bayer HealthCare AG | Plasmids, their construction and their use in the manufacture of interleukin-4 and interleukin-4 muteins |
| GB9912350D0 (en) | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| EP1284987B1 (en) * | 2000-05-16 | 2007-07-18 | Bolder Biotechnology, Inc. | Methods for refolding proteins containing free cysteine residues |
-
2001
- 2001-11-22 EP EP01127373A patent/EP1314739A1/en not_active Withdrawn
-
2002
- 2002-11-12 AU AU2002340510A patent/AU2002340510A1/en not_active Abandoned
- 2002-11-12 PT PT02774777T patent/PT1453858E/pt unknown
- 2002-11-12 DK DK02774777.3T patent/DK1453858T3/da active
- 2002-11-12 WO PCT/EP2002/012607 patent/WO2003044055A1/en active Application Filing
- 2002-11-12 AT AT02774777T patent/ATE495191T1/de active
- 2002-11-12 ES ES02774777T patent/ES2357888T3/es not_active Expired - Lifetime
- 2002-11-12 EP EP02774777A patent/EP1453858B1/en not_active Expired - Lifetime
- 2002-11-12 DE DE60238938T patent/DE60238938D1/de not_active Expired - Lifetime
- 2002-11-12 KR KR1020047007769A patent/KR100944845B1/ko not_active IP Right Cessation
- 2002-11-12 JP JP2003545690A patent/JP4348188B2/ja not_active Expired - Fee Related
- 2002-11-12 US US10/495,417 patent/US7893210B2/en not_active Expired - Fee Related
-
2011
- 2011-03-29 CY CY20111100332T patent/CY1112209T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20050014933A1 (en) | 2005-01-20 |
| DE60238938D1 (de) | 2011-02-24 |
| CY1112209T1 (el) | 2015-12-09 |
| WO2003044055A1 (en) | 2003-05-30 |
| US7893210B2 (en) | 2011-02-22 |
| ES2357888T3 (es) | 2011-05-03 |
| PT1453858E (pt) | 2011-03-16 |
| AU2002340510A1 (en) | 2003-06-10 |
| JP4348188B2 (ja) | 2009-10-21 |
| KR20050058243A (ko) | 2005-06-16 |
| EP1453858B1 (en) | 2011-01-12 |
| EP1314739A1 (en) | 2003-05-28 |
| EP1453858A1 (en) | 2004-09-08 |
| KR100944845B1 (ko) | 2010-03-04 |
| JP2005510217A (ja) | 2005-04-21 |
| ATE495191T1 (de) | 2011-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1112209T1 (el) | Διαδικασια για την αναδιαταξη των ανασυνδυασμενων πρωτεϊνων που περιεχουν δισουλφιδιο, σε υψηλες συγκεντρωσεις πρωτεϊνων με την παρουσια αμινων | |
| DK1095056T3 (da) | Höjtryksrefoldning af proteinaggregater og inklusionslegemer | |
| DE60034707D1 (de) | Allgemeines verfahren zur rückfaltung rekombinanter proteine | |
| ATE322501T1 (de) | Verfahren zur rückfaltung von chemisch hergestellten polypeptiden | |
| DK1084146T3 (da) | Hybridprotein til inhibering af degranuleringen af mastocyter og anvendelse deraf | |
| ATE363491T1 (de) | Reinigung von antikörpern durch protein a und ionenaustauschromatographie | |
| ATE543506T1 (de) | Methode zur stabilisierung von proteinen | |
| DK1904529T3 (da) | Anvendelse af Stefin A som et scaffoldprotein | |
| ATE292074T1 (de) | Abschlussteil | |
| DE59509642D1 (de) | Verfahren zur modifizierung der stabilität von antikörpern | |
| BR9709569B1 (pt) | processo para ativação de proteìna desnaturada. | |
| ATE417056T1 (de) | Verfahren zur proteinreinigung | |
| WO2000001831A3 (en) | Proteases fused with variants of streptomyces subtilisin inhibitor | |
| DE60118935D1 (de) | Dna & protein bindende miniatur proteine | |
| DK1587839T3 (da) | Lys-induceret immobilisering | |
| ATE381619T1 (de) | Verfahren zur herstellung von rekombinantem insulin durch fusionsproteine | |
| ATE508137T1 (de) | Verfahren zur isolierung und reinigung von trypsin aus pronase und ihre verwendung | |
| ATE319837T1 (de) | Verfahren zur herstellung von rekombinantem trypsin | |
| DE60334316D1 (de) | Frpb proteinmutante und verfahren zur erneuten faltung | |
| DK2186898T3 (da) | Blomstrings-induktion | |
| Kos et al. | Isolation and characterization of chicken egg white low-Mr kininogen | |
| DE60126283D1 (de) | Verfahren zum Rekonstituieren eines biologisch aktiven rekombinanten Proteins | |
| FI20031050A (fi) | Menetelmä proteiinien katkaisuun | |
| HUP0301489A2 (en) | Method of protein purification and recovery |