DK1446128T3 - Anvendelse af östrogenforbindelser i kombination med progestogenforbindelser i hormonsubstitutionsbehandling - Google Patents
Anvendelse af östrogenforbindelser i kombination med progestogenforbindelser i hormonsubstitutionsbehandlingInfo
- Publication number
- DK1446128T3 DK1446128T3 DK02738962T DK02738962T DK1446128T3 DK 1446128 T3 DK1446128 T3 DK 1446128T3 DK 02738962 T DK02738962 T DK 02738962T DK 02738962 T DK02738962 T DK 02738962T DK 1446128 T3 DK1446128 T3 DK 1446128T3
- Authority
- DK
- Denmark
- Prior art keywords
- component
- compounds
- aforementioned
- hormone replacement
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 229940011871 estrogen Drugs 0.000 title 1
- 239000000262 estrogen Substances 0.000 title 1
- 238000002657 hormone replacement therapy Methods 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 title 1
- 230000001076 estrogenic effect Effects 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 230000000757 progestagenic effect Effects 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01204377 | 2001-11-15 | ||
EP02075695 | 2002-02-21 | ||
PCT/NL2002/000332 WO2003041718A1 (en) | 2001-11-15 | 2002-05-23 | Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1446128T3 true DK1446128T3 (da) | 2007-04-02 |
Family
ID=26077031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02738962T DK1446128T3 (da) | 2001-11-15 | 2002-05-23 | Anvendelse af östrogenforbindelser i kombination med progestogenforbindelser i hormonsubstitutionsbehandling |
Country Status (10)
Country | Link |
---|---|
US (1) | US8026228B2 (es) |
EP (1) | EP1446128B1 (es) |
AT (1) | ATE347365T1 (es) |
CA (1) | CA2467222C (es) |
CY (1) | CY1105957T1 (es) |
DE (1) | DE60216630T2 (es) |
DK (1) | DK1446128T3 (es) |
ES (1) | ES2278925T3 (es) |
PT (1) | PT1446128E (es) |
WO (1) | WO2003041718A1 (es) |
Families Citing this family (50)
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US20040214807A1 (en) * | 1993-08-06 | 2004-10-28 | D'amato Robert J. | Estrogenic compounds as anti-mitotic agents |
US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
PT1390042E (pt) * | 2001-05-23 | 2008-03-10 | Pantarhei Bioscience Bv | Sistema de administração de um medicamento que compreende estrogénio tetrahidroxilado destinado à contracepção hormonal |
SI1562976T1 (sl) | 2002-11-08 | 2010-08-31 | Pantarhei Bioscience Bv | Sinteza estetrola preko steroidov, izvedenih iz estrona |
CA2527074A1 (en) * | 2003-05-28 | 2005-04-07 | Entremed, Inc. | Antiangiogenic agents |
PL1635843T3 (pl) * | 2003-06-25 | 2009-06-30 | Bayer Schering Pharma Ag | Hormonalna terapia zastępcza i leczenie depresji obejmujące dienogest |
WO2005089256A2 (en) | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Antiangiogenic agents |
US20070004689A1 (en) * | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
CA2587448A1 (en) * | 2004-11-29 | 2006-06-01 | Entremed, Inc. | A method of administering anti-angiogenic agents and a method of treating disease using same |
US20070185069A1 (en) * | 2005-11-14 | 2007-08-09 | Plum Stacy M | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
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AU2007227256B2 (en) * | 2006-03-20 | 2012-10-04 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
WO2008019048A1 (en) * | 2006-08-04 | 2008-02-14 | Meditrina Pharmaceuticals | Use of aromatase inhibitors for thining the endometrium or treating menorrhagia |
US8236785B2 (en) * | 2007-01-08 | 2012-08-07 | Pantarhei Bioscience B.V. | Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method |
US20080234243A1 (en) * | 2007-01-31 | 2008-09-25 | Lavallee Theresa M | Method of treating amyloidosis mediated diseases |
US20100292150A1 (en) * | 2007-12-10 | 2010-11-18 | Meditrina Pharmaceuticals, Inc. | Treatment of Menorrhagia with Aromatase Inhibitor |
US9446051B2 (en) * | 2009-10-19 | 2016-09-20 | The Population Council, Inc. | Neuroprotection and myelin repair using nestorone® |
EP2490680B1 (en) | 2009-10-19 | 2018-04-04 | The Population Council, Inc. | Neuroprotection and myelin repair using nestorone® |
PT2714712T (pt) | 2011-06-01 | 2016-11-08 | Estetra Sprl | Processo para a produção de intermediários de estetrol |
WO2012164096A1 (en) | 2011-06-01 | 2012-12-06 | Estetra S.A. | Process for the production of estetrol intermediates |
EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
WO2013034780A2 (en) | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol and related compounds |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
WO2015040051A1 (en) | 2013-09-18 | 2015-03-26 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol |
MA39105B1 (fr) | 2013-12-12 | 2018-05-31 | Donesta Bioscience B V | Unité de dosage solide se désintégrant par voie orale contenant un constituant estétrol |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
MA44205B1 (fr) | 2015-06-18 | 2021-04-30 | Estetra Sprl | Comprimé orodispersible comprenant estetrol |
TN2017000497A1 (en) | 2015-06-18 | 2019-04-12 | Mithra Pharmaceuticals S A | Orodispersible dosage unit containing an estetrol component |
MX2017016276A (es) | 2015-06-18 | 2018-06-19 | Mithra Pharmaceuticals S A | Unidad de dosificacion orodispersable que contiene un componente estetrol. |
LT3310346T (lt) * | 2015-06-18 | 2021-06-10 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
KR20220144885A (ko) | 2016-08-05 | 2022-10-27 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
TWI801561B (zh) * | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
CA3237490A1 (en) * | 2021-11-29 | 2023-06-01 | Estetra Srl | Compositions for preventing or treating skin aging |
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US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
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DE2336433A1 (de) * | 1973-07-13 | 1975-04-03 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
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US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
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US5340586A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
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AU5137900A (en) | 1999-05-28 | 2000-12-18 | University Of Cincinnati, The | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
AU2001259847B9 (en) | 2000-05-12 | 2006-08-10 | Oregon Health And Science University | Method of treating immune pathologies with low dose estrogen |
US6936599B2 (en) * | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
EP1260225A1 (en) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | A pharmaceutical composition for use in hormone replacement therapy |
-
2002
- 2002-05-23 EP EP02738962A patent/EP1446128B1/en not_active Expired - Lifetime
- 2002-05-23 PT PT02738962T patent/PT1446128E/pt unknown
- 2002-05-23 US US10/495,707 patent/US8026228B2/en active Active
- 2002-05-23 CA CA2467222A patent/CA2467222C/en not_active Expired - Lifetime
- 2002-05-23 AT AT02738962T patent/ATE347365T1/de not_active IP Right Cessation
- 2002-05-23 DK DK02738962T patent/DK1446128T3/da active
- 2002-05-23 DE DE60216630T patent/DE60216630T2/de not_active Expired - Lifetime
- 2002-05-23 ES ES02738962T patent/ES2278925T3/es not_active Expired - Lifetime
- 2002-05-23 WO PCT/NL2002/000332 patent/WO2003041718A1/en active IP Right Grant
-
2007
- 2007-01-29 CY CY20071100107T patent/CY1105957T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2467222A1 (en) | 2003-05-22 |
US20050070488A1 (en) | 2005-03-31 |
CY1105957T1 (el) | 2011-04-06 |
DE60216630D1 (de) | 2007-01-18 |
ATE347365T1 (de) | 2006-12-15 |
US8026228B2 (en) | 2011-09-27 |
ES2278925T3 (es) | 2007-08-16 |
CA2467222C (en) | 2010-06-08 |
WO2003041718A1 (en) | 2003-05-22 |
PT1446128E (pt) | 2007-03-30 |
EP1446128B1 (en) | 2006-12-06 |
EP1446128A1 (en) | 2004-08-18 |
DE60216630T2 (de) | 2007-09-20 |
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