DK1427403T3 - Valproinsyre til behandling af brystkræft, kolonkræft, hoved- og halskræft, lillecelle-lungecarcinom og kræft i blodceller i kombination med bestråling - Google Patents

Valproinsyre til behandling af brystkræft, kolonkræft, hoved- og halskræft, lillecelle-lungecarcinom og kræft i blodceller i kombination med bestråling

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Publication number
DK1427403T3
DK1427403T3 DK02777129T DK02777129T DK1427403T3 DK 1427403 T3 DK1427403 T3 DK 1427403T3 DK 02777129 T DK02777129 T DK 02777129T DK 02777129 T DK02777129 T DK 02777129T DK 1427403 T3 DK1427403 T3 DK 1427403T3
Authority
DK
Denmark
Prior art keywords
cancer
treatment
combination
radiation
head
Prior art date
Application number
DK02777129T
Other languages
Danish (da)
English (en)
Inventor
Bernd Groner
Bernd Hentsch
Peter A Herrlich
Pier Giuseppe Pelicci
Martin Goettlicher
Thorsten Heinzel
Winfried Stephan Wels
Saverio Minucci
Original Assignee
Topotarget Germany Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topotarget Germany Ag filed Critical Topotarget Germany Ag
Application granted granted Critical
Publication of DK1427403T3 publication Critical patent/DK1427403T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK02777129T 2001-09-18 2002-09-17 Valproinsyre til behandling af brystkræft, kolonkræft, hoved- og halskræft, lillecelle-lungecarcinom og kræft i blodceller i kombination med bestråling DK1427403T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01121722A EP1293205A1 (en) 2001-09-18 2001-09-18 Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease

Publications (1)

Publication Number Publication Date
DK1427403T3 true DK1427403T3 (da) 2006-04-03

Family

ID=8178602

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02777129T DK1427403T3 (da) 2001-09-18 2002-09-17 Valproinsyre til behandling af brystkræft, kolonkræft, hoved- og halskræft, lillecelle-lungecarcinom og kræft i blodceller i kombination med bestråling

Country Status (11)

Country Link
US (1) US20050038113A1 (el)
EP (4) EP1293205A1 (el)
JP (1) JP2005512961A (el)
AT (1) ATE314063T1 (el)
AU (1) AU2002338716B2 (el)
CA (1) CA2460713A1 (el)
CY (1) CY1105552T1 (el)
DE (1) DE60208397T2 (el)
DK (1) DK1427403T3 (el)
ES (1) ES2252519T3 (el)
WO (1) WO2003024442A2 (el)

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WO2006122319A2 (en) * 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
PL1901729T3 (pl) 2005-05-13 2012-07-31 Topotarget Uk Ltd Formulacje farmaceutyczne inhibitorów hdac
BRPI0613429A2 (pt) * 2005-07-14 2009-02-10 Takeda San Diego Inc inibidores de histona desacetilase
AU2006313517B2 (en) 2005-11-10 2013-06-27 Topotarget Uk Limited Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent
BRPI0520686A2 (pt) * 2005-11-16 2009-05-19 Univ Mexico Nacional Autonoma uso de agentes modificantes de transcriptoma associado a quimioterapia ou radioterapia contra o cáncer
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WO2007108272A1 (ja) * 2006-03-23 2007-09-27 Tmrc Co., Ltd. 癌治療用キットおよび癌治療用医薬組成物
WO2008013589A2 (en) 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Treatment of ras-expressing tumors
DE102006022877B4 (de) 2006-05-15 2009-01-29 Sartorius Stedim Biotech Gmbh Verfahren zur Bestimmung der Viabilität von Zellen in Zellkulturen
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
WO2008027837A2 (en) * 2006-08-28 2008-03-06 The Regents Of The University Of California Small molecule potentiator of hormonal therapy for breast cancer
CA2671649A1 (en) * 2006-12-06 2008-06-12 Sapporo Medical University Potentiation of cellular immunity using histone deacetylase (hdac) inhibitors
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
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CA2726734C (en) * 2007-06-06 2014-10-07 University Of Maryland, Baltimore Hdac inhibitor ms-275 and aromatase inhibitors for the treatment of cancer
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JPWO2010064422A1 (ja) * 2008-12-02 2012-05-10 静岡県公立大学法人 ヒストン高アセチル化状態における光増感処理による腫瘍殺傷法
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
RU2607634C2 (ru) 2010-07-12 2017-01-10 Селджин Корпорейшн Твердые формы ромидепсина и их применение
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
KR101733189B1 (ko) 2010-10-06 2017-05-08 (주)아모레퍼시픽 손톱 또는 발톱 성장 촉진용 조성물
JP5999724B2 (ja) * 2011-03-21 2016-09-28 ヴァルキュリア アクチアボラグＶａｌｃｕｒｉａ ＡＢ Ｈｄａｃ阻害剤及びステロイドを含む医薬組成物及びその使用
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
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JP6551963B2 (ja) * 2014-05-14 2019-07-31 国立大学法人京都大学 巨核球前駆細胞の製造方法
CN106794175B (zh) 2014-06-12 2020-06-09 西达-赛奈医疗中心 用于治疗癌症的组合物
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Also Published As

Publication number Publication date
EP1529527A3 (en) 2005-05-25
WO2003024442A3 (en) 2003-09-18
EP1529527A2 (en) 2005-05-11
EP1602371A2 (en) 2005-12-07
US20050038113A1 (en) 2005-02-17
ES2252519T3 (es) 2006-05-16
EP1293205A1 (en) 2003-03-19
DE60208397D1 (de) 2006-02-02
AU2002338716B2 (en) 2007-08-16
EP1427403A2 (en) 2004-06-16
EP1427403B1 (en) 2005-12-28
ATE314063T1 (de) 2006-01-15
CA2460713A1 (en) 2003-03-27
EP1602371A3 (en) 2006-11-15
DE60208397T2 (de) 2006-07-13
JP2005512961A (ja) 2005-05-12
WO2003024442A2 (en) 2003-03-27
EP1427403B8 (en) 2006-03-22
CY1105552T1 (el) 2010-07-28

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