DK1424321T3 - Syntese af optisk aktive cyclohexylphenylglycolsyreestere - Google Patents

Syntese af optisk aktive cyclohexylphenylglycolsyreestere

Info

Publication number
DK1424321T3
DK1424321T3 DK03104950T DK03104950T DK1424321T3 DK 1424321 T3 DK1424321 T3 DK 1424321T3 DK 03104950 T DK03104950 T DK 03104950T DK 03104950 T DK03104950 T DK 03104950T DK 1424321 T3 DK1424321 T3 DK 1424321T3
Authority
DK
Denmark
Prior art keywords
synthesis
acid esters
optically active
cyclohexylphenylglycolic acid
cyclohexylphenylglycolic
Prior art date
Application number
DK03104950T
Other languages
English (en)
Inventor
Roger P Bakale
Jorge L Lopez
Francis X Mcconville
Charles P Vandenbossche
Chris Hugh Senanayake
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/177,456 external-priority patent/US5973182A/en
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of DK1424321T3 publication Critical patent/DK1424321T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96Esters of carbonic or haloformic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/487Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/12Preparation of carboxylic acid esters from asymmetrical anhydrides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00Preparation of esters of carbonic or haloformic acids
    • C07C68/02Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK03104950T 1998-10-22 1999-10-22 Syntese af optisk aktive cyclohexylphenylglycolsyreestere DK1424321T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/177,456 US5973182A (en) 1998-10-22 1998-10-22 Carbonate Intermediates useful in the preparation of optically active cyclohexylphenylglycolate esters
US09/211,646 US6140529A (en) 1998-10-22 1998-12-15 Synthesis of optically active cyclohexylphenylglycolate esters
EP99953250A EP1185498B1 (en) 1998-10-22 1999-10-22 Synthesis of optically active cyclohexylphenylglycolic acid and its esters

Publications (1)

Publication Number Publication Date
DK1424321T3 true DK1424321T3 (da) 2006-07-31

Family

ID=26873314

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03104950T DK1424321T3 (da) 1998-10-22 1999-10-22 Syntese af optisk aktive cyclohexylphenylglycolsyreestere
DK99953250T DK1185498T3 (da) 1998-10-22 1999-10-22 Syntese af optisk aktiv cyclohexylphenylglycolsyre og dens estere

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99953250T DK1185498T3 (da) 1998-10-22 1999-10-22 Syntese af optisk aktiv cyclohexylphenylglycolsyre og dens estere

Country Status (11)

Country Link
US (1) US6140529A (da)
EP (3) EP1642883A3 (da)
JP (1) JP2002527500A (da)
AT (2) ATE332290T1 (da)
AU (2) AU766066B2 (da)
CA (1) CA2347736A1 (da)
DE (2) DE69916134T2 (da)
DK (2) DK1424321T3 (da)
ES (2) ES2266726T3 (da)
PT (2) PT1424321E (da)
WO (1) WO2000023414A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180823B1 (en) * 1998-11-06 2001-01-30 Sepracor Inc. Stereoselective process for alkyl phenylglycolic acids
CA2361156A1 (en) * 2000-11-07 2002-05-07 Sumika Fine Chemicals Co., Ltd. Production method of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid, intermediate therefor and production method thereof
US6825378B2 (en) * 2003-03-28 2004-11-30 Council Of Scientific And Industrial Research Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid
CN103012231B (zh) * 2012-12-14 2015-08-05 沈阳药科大学 格隆溴铵手性对映体的制备方法和应用
CN103772188B (zh) * 2014-02-25 2015-09-23 成都百事兴科技实业有限公司 R-(+)-α-环己基扁桃酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB708370A (en) * 1950-12-27 1954-05-05 Albert Boehringer Process for the production of scopolamine-bromobutylate
GB750156A (en) * 1953-03-23 1956-06-13 Wellcome Found Improvements in cyclohexyl-phenyl-amino-propanols
US2837525A (en) * 1955-07-12 1958-06-03 Sterling Drug Inc 1-thienyl-1-cycloalkyl (or aryl)-3-(aliphatic-tertiary-amino)-1-hydroxy-lower-alkanes and preparation thereof
NL124473C (da) * 1960-07-26
JP2651411B2 (ja) * 1988-06-13 1997-09-10 日本ヘキスト・マリオン・ルセル株式会社 アルキルアミノアセチレングリコール酸エステルの製法
IL91377A (en) * 1988-09-14 1996-09-12 Nippon Shinyaku Co Ltd Derivatives of botinylamine glycolate
CA2259316A1 (en) * 1996-07-01 1998-01-08 Bridge Pharma, Inc. Smooth muscle spasmolytic agents, compositions and methods of use thereof

Also Published As

Publication number Publication date
ES2266726T3 (es) 2007-03-01
EP1642883A2 (en) 2006-04-05
ES2215406T3 (es) 2004-10-01
CA2347736A1 (en) 2000-04-27
AU2003271292A1 (en) 2004-01-29
US6140529A (en) 2000-10-31
PT1424321E (pt) 2006-09-29
DE69916134T2 (de) 2005-02-03
EP1185498A2 (en) 2002-03-13
ATE263134T1 (de) 2004-04-15
EP1424321B1 (en) 2006-07-05
EP1424321A1 (en) 2004-06-02
EP1185498B1 (en) 2004-03-31
AU766066B2 (en) 2003-10-09
AU6522299A (en) 2000-05-08
DK1185498T3 (da) 2004-07-26
ATE332290T1 (de) 2006-07-15
EP1642883A3 (en) 2006-05-03
DE69932269D1 (de) 2006-08-17
WO2000023414A2 (en) 2000-04-27
AU2003271292A2 (en) 2004-01-29
DE69932269T2 (de) 2006-11-23
PT1185498E (pt) 2004-06-30
JP2002527500A (ja) 2002-08-27
WO2000023414A3 (en) 2001-12-13
DE69916134D1 (de) 2004-05-06

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