DK1412368T3 - Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter - Google Patents

Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter

Info

Publication number
DK1412368T3
DK1412368T3 DK02765874T DK02765874T DK1412368T3 DK 1412368 T3 DK1412368 T3 DK 1412368T3 DK 02765874 T DK02765874 T DK 02765874T DK 02765874 T DK02765874 T DK 02765874T DK 1412368 T3 DK1412368 T3 DK 1412368T3
Authority
DK
Denmark
Prior art keywords
dihydroisomorphine
dihydromorphine
hydromorphone
pain
compositions
Prior art date
Application number
DK02765874T
Other languages
Danish (da)
English (en)
Inventor
Feng Gao
Jahanara Miotto
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of DK1412368T3 publication Critical patent/DK1412368T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK02765874T 2001-07-27 2002-07-24 Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter DK1412368T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30784501P 2001-07-27 2001-07-27
PCT/US2002/023553 WO2003011881A2 (en) 2001-07-27 2002-07-24 Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain

Publications (1)

Publication Number Publication Date
DK1412368T3 true DK1412368T3 (da) 2008-01-02

Family

ID=23191416

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02765874T DK1412368T3 (da) 2001-07-27 2002-07-24 Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter

Country Status (14)

Country Link
US (1) US6740641B2 (https=)
EP (1) EP1412368B1 (https=)
JP (1) JP4679055B2 (https=)
AT (1) ATE371665T1 (https=)
AU (1) AU2002329634B2 (https=)
CA (1) CA2455774C (https=)
CY (1) CY1107813T1 (https=)
DE (1) DE60222137T2 (https=)
DK (1) DK1412368T3 (https=)
ES (1) ES2292806T3 (https=)
IL (2) IL160085A0 (https=)
MX (1) MXPA04000825A (https=)
PT (1) PT1412368E (https=)
WO (1) WO2003011881A2 (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
KR100822498B1 (ko) * 2002-02-22 2008-04-16 샤이어 엘엘씨 규제된 물질의 남용을 방지하기 위한 새로운 서방성 약학화합물
WO2003072735A2 (en) * 2002-02-22 2003-09-04 New River Pharmaceuticals Inc. Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
SI1644019T2 (en) * 2003-05-29 2018-04-30 Shire Llc Abuse resistant amphetamine compounds
EA008864B1 (ru) * 2003-09-30 2007-08-31 Нью Ривер Фармасьютикалз Инк. Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств
JP5176188B2 (ja) * 2006-04-21 2013-04-03 ディーエスエム アイピー アセッツ ビー．ブイ． オピオイド受容体拮抗薬の使用
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
FR2939436B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Synthese de morphine-6-glucuronide ou de l'un de ses derives
US8716350B2 (en) * 2010-03-30 2014-05-06 Algynomics Inc. Compositions and methods for the treatment of somatosensory disorders
US8716349B2 (en) 2010-03-30 2014-05-06 Algynomics Inc. Compositions and methods for the treatment of somatosensory disorders
ES2566828T3 (es) 2010-09-21 2016-04-15 Purdue Pharma L.P. Análogos de buprenorfina como agonistas y/o antagonistas del receptor opioide
SG11201401856VA (en) 2011-10-26 2014-05-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
EP2917182B1 (en) 2012-11-09 2018-01-03 Purdue Pharma LP Benzomorphan analogs and the use thereof
WO2014087226A1 (en) 2012-12-07 2014-06-12 Purdue Pharma L.P. Buprenorphine analogs as opiod receptor modulators
EP2931724B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Pyridonemorphinan analogs and biological activity on opioid receptors
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
JP6182620B2 (ja) 2013-01-31 2017-08-16 パーデュー、ファーマ、リミテッド、パートナーシップ ベンゾモルファン類似体およびその使用
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
HU231191B1 (hu) 2013-04-15 2021-08-30 Szegedi Tudományegyetem Izotóp tartalmú morfin molekulák
EP3087057A4 (en) 2013-12-26 2017-06-28 Purdue Pharma LP Ring-contracted morphinans and the use thereof
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
WO2015097548A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015099863A1 (en) 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
CA2950567A1 (en) 2014-05-27 2015-12-03 Purdue Pharma L.P. Spirocyclic morphinans and use thereof
MA40171A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés d'azamophinan et leur utilisation
RU2683274C2 (ru) 2014-12-02 2019-03-27 Кемфарм, Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты и оксиморфона, их пролекарства, способы получения и применение
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
ITUB20154996A1 (it) 2015-10-27 2017-04-27 Nobili S P A Attrezzatura per l?erogazione di un liquido di trattamento ad una rispettiva coltura o piantagione agricola.
UA124972C2 (uk) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Способи лікування раку передміхурової залози
WO2018125716A1 (en) 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
WO2024042226A2 (en) * 2022-08-25 2024-02-29 Biosynth Gmbh Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE92497T1 (de) 1988-01-12 1993-08-15 Baker Norton Pharma Glucuronsaeure-derivate von opioid-antagonisten.
FR2680786B1 (fr) * 1991-09-04 1995-03-10 Irepa Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
EP0816375A1 (en) * 1995-11-29 1998-01-07 Rolabo Sl Glycoconjugates of opiated substances
GB9711118D0 (en) 1997-05-29 1997-07-23 Rolabo Sl Compound

Also Published As

Publication number Publication date
DE60222137D1 (de) 2007-10-11
WO2003011881A3 (en) 2003-10-30
CA2455774A1 (en) 2003-02-13
EP1412368B1 (en) 2007-08-29
EP1412368A2 (en) 2004-04-28
JP2005500357A (ja) 2005-01-06
ES2292806T3 (es) 2008-03-16
MXPA04000825A (es) 2004-05-17
JP4679055B2 (ja) 2011-04-27
CY1107813T1 (el) 2013-06-19
IL160085A (en) 2010-12-30
AU2002329634B2 (en) 2009-01-29
ATE371665T1 (de) 2007-09-15
IL160085A0 (en) 2004-06-20
CA2455774C (en) 2011-06-07
PT1412368E (pt) 2007-11-06
US20030050257A1 (en) 2003-03-13
WO2003011881A2 (en) 2003-02-13
DE60222137T2 (de) 2008-06-05
US6740641B2 (en) 2004-05-25

Similar Documents

Publication Publication Date Title
DK1412368T3 (da) Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter
DK1636236T3 (da) Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
TR200500745T2 (tr) Damar gelişimi inhibitörleri olarak kuinazolin türevleri.
NO20061245L (no) Farmasoytiske sammensetninger og fremgangsmater omfattende kombinasjoner av 2-alkyliden-19-nor-vitamin D derivater og en bisfosfon
NO20035438L (no) Farmasoytisk formulering for effektiv administrering av apomorfin, 6aR-(-)-N-propyl-norapomorfin og deres derivater og prodrugs derav
EE200200565A (et) Vaskulaarse kahjustava toimega kombinatsioonravi
NO20024076L (no) Sammensetning omfattende camptotecin og et pyrimidinderivat for behandling av cancer
MXPA03009849A (es) Uso de azitromicina para la fabricacion de un medicamento para el tratamiento de enfermedades inflamatorias no infecciosas.
DK1039900T3 (da) Farmaceutisk præparat indeholdende sibutramin og orlistat
WO2005065648A3 (en) Novel drug compositions and dosage forms of topiramate
NO20031410D0 (no) Antitumorterapi innbefattende distamycinderivater
WO2007064448A3 (en) Cancer treatment using fts and 2-deoxyglucose
NO20063277L (no) Farmasoytisk sammensetning av vinflunin som er ment for parenteral administrering, fremstillingsmate og anvendelse derav
CA2385755A1 (en) Prevention of colorectal cancer
MXPA04001912A (es) Aminobenzofenonas novedosas.
NO20021337D0 (no) 4-benzylaminoquinolinkonjugater med gallesyre og deres heteroanaloger, fremgangsmåte for deres fremstilling, legemidlersom inneholder disse forbindelser og deres anvendelse
WO2004073627A3 (en) Novel therapeutic method and compositions for topical administration
IS7418A (is) Sítalópram til að meðhöndla hækkaðan blóðþrýsting
RU99108220A (ru) Способ лечения острого периода гипоталамического синдрома пубертатного периода
DK1399141T3 (da) Anvendelse af acetyl L-carnitin til fremstilling af et lægemiddel til forebyggende terapi af post-kirurgisk smerte
WO2003066806A3 (en) Therapeutic use of aziridino compounds
DK1439885T3 (da) Forenklede sarcodictynderivater som antitumormidler
EA200701086A1 (ru) Производные изоксазола, их фармацевтические композиции и способ лечения невропатической боли