DK140288A - Fremgangsmaade til oprensning af plasminogenaktivator - Google Patents

Fremgangsmaade til oprensning af plasminogenaktivator

Info

Publication number
DK140288A
DK140288A DK140288A DK140288A DK140288A DK 140288 A DK140288 A DK 140288A DK 140288 A DK140288 A DK 140288A DK 140288 A DK140288 A DK 140288A DK 140288 A DK140288 A DK 140288A
Authority
DK
Denmark
Prior art keywords
cleaning
plasminogen activator
plasminogen
activator
cleaning plasminogen
Prior art date
Application number
DK140288A
Other languages
Danish (da)
English (en)
Other versions
DK140288D0 (da
Inventor
Andrew Charles Kenney
Angela Joyce Perry
Susan White
Fiona Angela Olinda Marston
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868617394A external-priority patent/GB8617394D0/en
Priority claimed from GB878709288A external-priority patent/GB8709288D0/en
Application filed by Celltech Ltd filed Critical Celltech Ltd
Publication of DK140288D0 publication Critical patent/DK140288D0/da
Publication of DK140288A publication Critical patent/DK140288A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK140288A 1986-07-16 1988-03-15 Fremgangsmaade til oprensning af plasminogenaktivator DK140288A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB868617394A GB8617394D0 (en) 1986-07-16 1986-07-16 Purification process
GB878709288A GB8709288D0 (en) 1987-04-16 1987-04-16 Purification process
PCT/GB1987/000498 WO1988000615A1 (en) 1986-07-16 1987-07-15 Process for purifying a plasminogen activator

Publications (2)

Publication Number Publication Date
DK140288D0 DK140288D0 (da) 1988-03-15
DK140288A true DK140288A (da) 1988-04-28

Family

ID=26291050

Family Applications (1)

Application Number Title Priority Date Filing Date
DK140288A DK140288A (da) 1986-07-16 1988-03-15 Fremgangsmaade til oprensning af plasminogenaktivator

Country Status (5)

Country Link
EP (1) EP0275282A1 (ja)
JP (1) JPH01500563A (ja)
AU (1) AU7709287A (ja)
DK (1) DK140288A (ja)
WO (1) WO1988000615A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
US20090130714A1 (en) * 2007-09-24 2009-05-21 Reliance Life Sciences Pvt.Ltd. Process for purifying recombinanat tissue plasminogen activator (TPA)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5935B2 (ja) * 1977-06-03 1984-01-05 住友化学工業株式会社 ウロキナ−ゼの精製法
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
EP0125254A1 (en) * 1982-10-28 1984-11-21 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
WO1984001714A1 (en) * 1982-10-29 1984-05-10 Mitsui Toatsu Chemicals Novel plasminogen activator, process for its preparation, and thrombolytic drug containing the same
EP0163751B1 (en) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
DK175327B1 (da) * 1984-10-01 2004-08-23 Integrated Genetics Inc Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)
JPS61221128A (ja) * 1985-03-26 1986-10-01 Snow Brand Milk Prod Co Ltd プラスミノ−ゲン活性化因子に対するモノクロ−ナル抗体とその調製方法及び該モノクロ−ナル抗体の使用方法
AU606582B2 (en) * 1985-09-06 1991-02-14 Codon Methods for the recovery of tissue plasminogen activator

Also Published As

Publication number Publication date
WO1988000615A1 (en) 1988-01-28
AU7709287A (en) 1988-02-10
DK140288D0 (da) 1988-03-15
JPH01500563A (ja) 1989-03-01
EP0275282A1 (en) 1988-07-27

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment