DK130390A - Praeparat af i prokaryonter udtrykt plasminogenaktivator - Google Patents

Praeparat af i prokaryonter udtrykt plasminogenaktivator Download PDF

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Publication number
DK130390A
DK130390A DK130390A DK130390A DK130390A DK 130390 A DK130390 A DK 130390A DK 130390 A DK130390 A DK 130390A DK 130390 A DK130390 A DK 130390A DK 130390 A DK130390 A DK 130390A
Authority
DK
Denmark
Prior art keywords
preparation
plasminogen activator
activator expressed
expressed
plasminogen
Prior art date
Application number
DK130390A
Other languages
English (en)
Other versions
DK130390D0 (da
Inventor
Rainer Rudolph
Ulrich Opitz
Ulrich Kohnert
Stephan Fischer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK130390A publication Critical patent/DK130390A/da
Publication of DK130390D0 publication Critical patent/DK130390D0/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK130390A 1988-09-28 1990-05-25 Praeparat af i prokaryonter udtrykt plasminogenaktivator DK130390D0 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3832898A DE3832898A1 (de) 1988-09-28 1988-09-28 Praeparat von in prokaryonten exprimiertem plasminogenaktivator
PCT/EP1989/001139 WO1990003388A1 (de) 1988-09-28 1989-09-28 Präparat von in prokaryonten exprimiertem plasminogenaktivator

Publications (2)

Publication Number Publication Date
DK130390A true DK130390A (da) 1990-05-25
DK130390D0 DK130390D0 (da) 1990-05-25

Family

ID=6363884

Family Applications (1)

Application Number Title Priority Date Filing Date
DK130390A DK130390D0 (da) 1988-09-28 1990-05-25 Praeparat af i prokaryonter udtrykt plasminogenaktivator

Country Status (7)

Country Link
EP (1) EP0361475A1 (da)
JP (1) JPH02503635A (da)
AU (1) AU620927B2 (da)
DE (1) DE3832898A1 (da)
DK (1) DK130390D0 (da)
IL (1) IL91774A0 (da)
WO (1) WO1990003388A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0547102B1 (en) * 1990-09-05 1998-07-08 Southern Cross Biotech Pty.Ltd. Solubilization of proteins in active forms
US5965424A (en) * 1991-01-11 1999-10-12 Boehringer Mannheim Gmbh Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases
DE4140699A1 (de) * 1991-01-11 1992-07-16 Boehringer Mannheim Gmbh Rekombinante iga-protease
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
AU714318B2 (en) * 1996-06-11 2000-01-06 Roche Diagnostics Gmbh Process for the activation of denatured protein
US20090130714A1 (en) * 2007-09-24 2009-05-21 Reliance Life Sciences Pvt.Ltd. Process for purifying recombinanat tissue plasminogen activator (TPA)
CN103852527B (zh) * 2012-12-05 2015-05-13 中国科学院大连化学物理研究所 一种高通量蛋白质样品预处理装置

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (da) * 1982-12-22 1984-10-02 Genentech Inc
JPS6229975A (ja) * 1985-08-01 1987-02-07 Mitsui Toatsu Chem Inc 粗ｔＰＡの精製法
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
JPH0779692B2 (ja) * 1986-05-07 1995-08-30 三井東圧化学株式会社 一本鎖ｔ−ＰＡと二本鎖ｔ−ＰＡを分離する方法
AU7709287A (en) * 1986-07-16 1988-02-10 Celltech Limited Process for purifying a plasminogen activator

Also Published As

Publication number Publication date
EP0361475A1 (de) 1990-04-04
AU4338589A (en) 1990-04-18
JPH02503635A (ja) 1990-11-01
IL91774A0 (en) 1990-06-10
DK130390D0 (da) 1990-05-25
DE3832898A1 (de) 1990-04-12
AU620927B2 (en) 1992-02-27
WO1990003388A1 (de) 1990-04-05

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment