DK130390A - PREPARATION OF PLASMINOGEN ACTIVATOR EXPRESSED - Google Patents

PREPARATION OF PLASMINOGEN ACTIVATOR EXPRESSED Download PDF

Info

Publication number
DK130390A
DK130390A DK130390A DK130390A DK130390A DK 130390 A DK130390 A DK 130390A DK 130390 A DK130390 A DK 130390A DK 130390 A DK130390 A DK 130390A DK 130390 A DK130390 A DK 130390A
Authority
DK
Denmark
Prior art keywords
preparation
plasminogen activator
activator expressed
expressed
plasminogen
Prior art date
Application number
DK130390A
Other languages
Danish (da)
Other versions
DK130390D0 (en
Inventor
Rainer Rudolph
Ulrich Opitz
Ulrich Kohnert
Stephan Fischer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK130390D0 publication Critical patent/DK130390D0/en
Publication of DK130390A publication Critical patent/DK130390A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK130390A 1988-09-28 1990-05-25 PREPARATION OF PLASMINOGEN ACTIVATOR EXPRESSED DK130390A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3832898A DE3832898A1 (en) 1988-09-28 1988-09-28 PRAEPARATE OF EXPRESSED PLASMINOGEN ACTIVATOR IN PROKARYONS
PCT/EP1989/001139 WO1990003388A1 (en) 1988-09-28 1989-09-28 A preparation of plasminogen activator expressed in prokaryonts

Publications (2)

Publication Number Publication Date
DK130390D0 DK130390D0 (en) 1990-05-25
DK130390A true DK130390A (en) 1990-05-25

Family

ID=6363884

Family Applications (1)

Application Number Title Priority Date Filing Date
DK130390A DK130390A (en) 1988-09-28 1990-05-25 PREPARATION OF PLASMINOGEN ACTIVATOR EXPRESSED

Country Status (7)

Country Link
EP (1) EP0361475A1 (en)
JP (1) JPH02503635A (en)
AU (1) AU620927B2 (en)
DE (1) DE3832898A1 (en)
DK (1) DK130390A (en)
IL (1) IL91774A0 (en)
WO (1) WO1990003388A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0547102B1 (en) * 1990-09-05 1998-07-08 Southern Cross Biotech Pty.Ltd. Solubilization of proteins in active forms
US5965424A (en) * 1991-01-11 1999-10-12 Boehringer Mannheim Gmbh Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases
DE4140699A1 (en) * 1991-01-11 1992-07-16 Boehringer Mannheim Gmbh RECOMBINANT IGA PROTEASE
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6342585B1 (en) * 1996-06-11 2002-01-29 Roche Diagnostics Gmbh Method of activating denatured protein
US20090130714A1 (en) * 2007-09-24 2009-05-21 Reliance Life Sciences Pvt.Ltd. Process for purifying recombinanat tissue plasminogen activator (TPA)
CN103852527B (en) * 2012-12-05 2015-05-13 中国科学院大连化学物理研究所 High-flux protein sample pre-treatment device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (en) * 1982-12-22 1984-10-02 Genentech Inc
JPS6229975A (en) * 1985-08-01 1987-02-07 Mitsui Toatsu Chem Inc Purification of crude tpa
JPH0672105B2 (en) * 1985-10-02 1994-09-14 持田製薬株式会社 Thrombolytic agent and manufacturing method thereof
DE3537708A1 (en) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh METHOD FOR ACTIVATING T-PA AFTER EXPRESSION IN PROKARYONTS
FR2594845B1 (en) * 1986-02-21 1989-12-01 Genetica MICROBIOLOGICAL PREPARATION OF THE HUMAN PLASMINOGEN TISSUE ACTIVATOR (T-PA) AND CONVERSION OF THE ENZYME SO OBTAINED IN ITS ACTIVE FORM
DE3611817A1 (en) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh METHOD FOR RENATURING PROTEINS
DE3613401A1 (en) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh METHOD FOR PRODUCING PLASMINOGEN ACTIVATORS IN PROKARYONTS
DE3643158A1 (en) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION
JPH0779692B2 (en) * 1986-05-07 1995-08-30 三井東圧化学株式会社 Method for separating single-stranded t-PA and double-stranded t-PA
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
EP0275282A1 (en) * 1986-07-16 1988-07-27 Celltech Limited Process for purifying a plasminogen activator

Also Published As

Publication number Publication date
DE3832898A1 (en) 1990-04-12
DK130390D0 (en) 1990-05-25
IL91774A0 (en) 1990-06-10
EP0361475A1 (en) 1990-04-04
AU620927B2 (en) 1992-02-27
JPH02503635A (en) 1990-11-01
AU4338589A (en) 1990-04-18
WO1990003388A1 (en) 1990-04-05

Similar Documents

Publication Publication Date Title
DK237187A (en) PHARMACEUTICAL USE OF T-PA
DK193588D0 (en) APPLICATIONS OF DOPAMINAGONISTS
DK363887A (en) USE OF BROMCRUPTIN
DK96787A (en) HUMAN VAEVS PLASMINOGEN ACTIVATOR
DK273089D0 (en) USE OF PEPTIDE DERIVATIVES
DK372089A (en) USE OF ISOQUINOLINE DERIVATIVES
DK130390A (en) PREPARATION OF PLASMINOGEN ACTIVATOR EXPRESSED
DK141090D0 (en) PREPARATION OF HUMAN PROUROKINASE
DK120389A (en) USE OF PROGESTIN
DK104389D0 (en) USE OF IMIDAZOLD DERIVATIVES
ES2017606A4 (en) PREPARATION OF N - ACIL - AMINOMETILFOSFONATOS
DK102389D0 (en) USE OF INTERLEUKIN
DK87888D0 (en) THERAPEUTIC USE OF TINDIODDEUTEROPORFYRIN
DK104489D0 (en) APPLICATION OF TRIAZOLD DERIVATIVES
DK564886A (en) FUNGICID USE OF TETRAHYDROBENZOTHIENYLURINE INGREDIENTS
DK562289A (en) USE OF SOMATO STATINES
DK82592D0 (en) PREPARATION OF PROTEINS
KR900003361U (en) Deodorizer of refrigerator
DK541487D0 (en) SUMMARY OF MATERIALS
DK326789D0 (en) PREPARATION OF HOMONOJIRIMYCIN DERIVATIVES
IT8847653A0 (en) SIZZANTE INCLUDING 5 - PHARMACEUTICAL HYDROSCOMPOSITION OF ANOREXYTRPOPHANE
KR900003367U (en) Deodorizer of refrigerator
KR900004740U (en) Part of
DK0402857T3 (en) Use of 17beta-cyclopropylamino-androsten derivatives
DK621088D0 (en) THEEMBLY OF THE THEPOSET TYPE

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment