AU7709287A - Process for purifying a plasminogen activator - Google Patents

Process for purifying a plasminogen activator

Info

Publication number
AU7709287A
AU7709287A AU77092/87A AU7709287A AU7709287A AU 7709287 A AU7709287 A AU 7709287A AU 77092/87 A AU77092/87 A AU 77092/87A AU 7709287 A AU7709287 A AU 7709287A AU 7709287 A AU7709287 A AU 7709287A
Authority
AU
Australia
Prior art keywords
purifying
plasminogen activator
plasminogen
activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU77092/87A
Other languages
English (en)
Inventor
Andrew Charles Kenney
Fiona Angela Olinda Marston
Angela Joyce Perry
Susan White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868617394A external-priority patent/GB8617394D0/en
Priority claimed from GB878709288A external-priority patent/GB8709288D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of AU7709287A publication Critical patent/AU7709287A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU77092/87A 1986-07-16 1987-07-15 Process for purifying a plasminogen activator Abandoned AU7709287A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8617394 1986-07-16
GB868617394A GB8617394D0 (en) 1986-07-16 1986-07-16 Purification process
GB878709288A GB8709288D0 (en) 1987-04-16 1987-04-16 Purification process
GB8709288 1987-04-16

Publications (1)

Publication Number Publication Date
AU7709287A true AU7709287A (en) 1988-02-10

Family

ID=26291050

Family Applications (1)

Application Number Title Priority Date Filing Date
AU77092/87A Abandoned AU7709287A (en) 1986-07-16 1987-07-15 Process for purifying a plasminogen activator

Country Status (5)

Country Link
EP (1) EP0275282A1 (ja)
JP (1) JPH01500563A (ja)
AU (1) AU7709287A (ja)
DK (1) DK140288A (ja)
WO (1) WO1988000615A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU586355B2 (en) * 1986-09-22 1989-07-06 Mitsui Toatsu Chemicals Inc. Purification process of tpa
AU620927B2 (en) * 1988-09-28 1992-02-27 Boehringer Mannheim Gmbh A preparation of plasminogen activator expressed in prokaryotes

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
US20090130714A1 (en) * 2007-09-24 2009-05-21 Reliance Life Sciences Pvt.Ltd. Process for purifying recombinanat tissue plasminogen activator (TPA)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5935B2 (ja) * 1977-06-03 1984-01-05 住友化学工業株式会社 ウロキナ−ゼの精製法
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
EP0125254A1 (en) * 1982-10-28 1984-11-21 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
EP0124613B1 (en) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
DE3479814D1 (en) * 1984-06-05 1989-10-26 Asahi Chemical Ind Process for the preparation of a plasminogen activator
IE81135B1 (en) * 1984-10-01 2000-03-22 Genzyme Corp Recombinant DNA techniques and the products thereof
JPS61221128A (ja) * 1985-03-26 1986-10-01 Snow Brand Milk Prod Co Ltd プラスミノ−ゲン活性化因子に対するモノクロ−ナル抗体とその調製方法及び該モノクロ−ナル抗体の使用方法
EP0238551A4 (en) * 1985-09-06 1988-02-01 Codon METHODS OF RECOVERING A TISSUE PLASMINOGEN ACTIVATOR.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU586355B2 (en) * 1986-09-22 1989-07-06 Mitsui Toatsu Chemicals Inc. Purification process of tpa
AU620927B2 (en) * 1988-09-28 1992-02-27 Boehringer Mannheim Gmbh A preparation of plasminogen activator expressed in prokaryotes

Also Published As

Publication number Publication date
DK140288A (da) 1988-04-28
EP0275282A1 (en) 1988-07-27
WO1988000615A1 (en) 1988-01-28
JPH01500563A (ja) 1989-03-01
DK140288D0 (da) 1988-03-15

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