DK1399411T3 - Aloe-emodinderivater og anvendelse deraf i behandlingen af neoplasier - Google Patents
Aloe-emodinderivater og anvendelse deraf i behandlingen af neoplasierInfo
- Publication number
- DK1399411T3 DK1399411T3 DK02727865.4T DK02727865T DK1399411T3 DK 1399411 T3 DK1399411 T3 DK 1399411T3 DK 02727865 T DK02727865 T DK 02727865T DK 1399411 T3 DK1399411 T3 DK 1399411T3
- Authority
- DK
- Denmark
- Prior art keywords
- neoplasias
- treatment
- derivatives
- aloe
- emodin
- Prior art date
Links
- YDQWDHRMZQUTBA-UHFFFAOYSA-N Aloe emodin Chemical class C1=CC=C2C(=O)C3=CC(CO)=CC(O)=C3C(=O)C2=C1O YDQWDHRMZQUTBA-UHFFFAOYSA-N 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000009826 neoplastic cell growth Effects 0.000 title abstract 3
- 230000003013 cytotoxicity Effects 0.000 abstract 2
- 231100000135 cytotoxicity Toxicity 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/40—Succinic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/60—Maleic acid esters; Fumaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/80—Phthalic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/244—Anthraquinone radicals, e.g. sennosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000957A ITMI20010957A1 (it) | 2001-05-10 | 2001-05-10 | Derivati dell'aoe-emodina e loro impiego nel trattamento di patologieneoplastiche |
| PCT/IB2002/001604 WO2002090313A1 (en) | 2001-05-10 | 2002-05-10 | Aloe-emodin derivatives and their use in the treatment of neoplastic pathologies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1399411T3 true DK1399411T3 (da) | 2011-01-24 |
Family
ID=11447624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02727865.4T DK1399411T3 (da) | 2001-05-10 | 2002-05-10 | Aloe-emodinderivater og anvendelse deraf i behandlingen af neoplasier |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7268162B2 (da) |
| EP (1) | EP1399411B1 (da) |
| JP (1) | JP4467888B2 (da) |
| AT (1) | ATE482922T1 (da) |
| AU (1) | AU2002258050B2 (da) |
| CA (1) | CA2446429C (da) |
| DE (1) | DE60237818D1 (da) |
| DK (1) | DK1399411T3 (da) |
| ES (1) | ES2353203T3 (da) |
| IT (1) | ITMI20010957A1 (da) |
| WO (1) | WO2002090313A1 (da) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315884A (zh) * | 2020-10-30 | 2022-04-12 | 天津科技大学 | 两个大黄素衍生物的合成及其在抗人宫颈癌药物中的应用 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007132784A1 (ja) * | 2006-05-15 | 2007-11-22 | Niigata University | アントラキノン誘導体を有効成分として含有する抗精神病薬、認知異常の治療薬 |
| EP2526111A2 (en) | 2010-01-21 | 2012-11-28 | Ramot at Tel Aviv University, Ltd. | Aloe-emodin derivatives and use thereof for the treatment of cancer |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8734859B1 (en) | 2010-11-13 | 2014-05-27 | Sirbal Ltd. | Molecular combinations for cancer or other disease treatment |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| CN102838530A (zh) * | 2012-09-19 | 2012-12-26 | 陕西师范大学 | 芦荟大黄素衍生物及其制备方法 |
| WO2015082950A1 (en) | 2013-12-02 | 2015-06-11 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| CN104356014B (zh) * | 2014-11-07 | 2016-03-30 | 福州大学 | 具有抗癌活性的大黄素单链双季铵盐及其制备方法 |
| EP3328498B1 (en) | 2015-07-29 | 2021-05-05 | Sirbal Ltd. | Medical kit comprising herbal combinations for treating psoriasis |
| MY196214A (en) * | 2017-12-07 | 2023-03-23 | Jiangsu Kanion Pharmaceutical Co Ltd | Emodin Succinyl Ester Compound, Preparation Method Therefor and Application Thereof |
| IT202000004939A1 (it) | 2020-03-09 | 2021-09-09 | Palu Giorgio | Impieghi di 1,8-diidrossi-3-[idrossimetil]-antrachinone e suoi derivati |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1318547B1 (it) | 2000-05-31 | 2003-08-27 | Giorgio Palu | Impiego dell'aloe-emodin nel trattamento di patologie neoplastiche diorigine neuroectodermica. |
-
2001
- 2001-05-10 IT IT2001MI000957A patent/ITMI20010957A1/it unknown
-
2002
- 2002-05-10 JP JP2002587396A patent/JP4467888B2/ja not_active Expired - Fee Related
- 2002-05-10 ES ES02727865T patent/ES2353203T3/es not_active Expired - Lifetime
- 2002-05-10 AT AT02727865T patent/ATE482922T1/de active
- 2002-05-10 EP EP02727865A patent/EP1399411B1/en not_active Expired - Lifetime
- 2002-05-10 AU AU2002258050A patent/AU2002258050B2/en not_active Ceased
- 2002-05-10 US US10/477,347 patent/US7268162B2/en not_active Expired - Fee Related
- 2002-05-10 DK DK02727865.4T patent/DK1399411T3/da active
- 2002-05-10 WO PCT/IB2002/001604 patent/WO2002090313A1/en active IP Right Grant
- 2002-05-10 CA CA2446429A patent/CA2446429C/en not_active Expired - Fee Related
- 2002-05-10 DE DE60237818T patent/DE60237818D1/de not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315884A (zh) * | 2020-10-30 | 2022-04-12 | 天津科技大学 | 两个大黄素衍生物的合成及其在抗人宫颈癌药物中的应用 |
| CN114315884B (zh) * | 2020-10-30 | 2024-03-22 | 天津科技大学 | 两个大黄素衍生物的合成及其在抗人宫颈癌药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20040192623A1 (en) | 2004-09-30 |
| WO2002090313A1 (en) | 2002-11-14 |
| EP1399411B1 (en) | 2010-09-29 |
| CA2446429C (en) | 2011-06-21 |
| US7268162B2 (en) | 2007-09-11 |
| ES2353203T3 (es) | 2011-02-28 |
| EP1399411A1 (en) | 2004-03-24 |
| ITMI20010957A0 (it) | 2001-05-10 |
| WO2002090313A8 (en) | 2002-12-12 |
| AU2002258050B2 (en) | 2007-03-22 |
| ATE482922T1 (de) | 2010-10-15 |
| JP2004528372A (ja) | 2004-09-16 |
| CA2446429A1 (en) | 2002-11-14 |
| ITMI20010957A1 (it) | 2002-11-10 |
| JP4467888B2 (ja) | 2010-05-26 |
| DE60237818D1 (de) | 2010-11-11 |
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