DK1383919T3 - Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor - Google Patents

Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor

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Publication number
DK1383919T3
DK1383919T3 DK02725395.4T DK02725395T DK1383919T3 DK 1383919 T3 DK1383919 T3 DK 1383919T3 DK 02725395 T DK02725395 T DK 02725395T DK 1383919 T3 DK1383919 T3 DK 1383919T3
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Prior art keywords
receptor
compositions
methods
chain polypeptide
inhibitory factor
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Application number
DK02725395.4T
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Danish (da)
English (en)
Inventor
Richard J Bucala
Seamas Donnelly
Lin Leng
Christine N Metz
Robert Mitchell
Original Assignee
Cytokine Pharmasciences Inc
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Publication of DK1383919T3 publication Critical patent/DK1383919T3/da

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01—MEASURING; TESTING
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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DK02725395.4T 2001-03-29 2002-03-29 Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor DK1383919T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27943501P 2001-03-29 2001-03-29
PCT/US2002/009580 WO2002079517A1 (en) 2001-03-29 2002-03-29 Methods and compositions for using mhc class ii invariant chain polypeptide as a receptor for macrophage migration inhibitory factor

Publications (1)

Publication Number Publication Date
DK1383919T3 true DK1383919T3 (da) 2010-11-08

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ID=23068959

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Application Number Title Priority Date Filing Date
DK02725395.4T DK1383919T3 (da) 2001-03-29 2002-03-29 Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor

Country Status (10)

Country Link
US (10) US20030013122A1 (https=)
EP (1) EP1383919B1 (https=)
JP (1) JP4202763B2 (https=)
AT (1) ATE473294T1 (https=)
AU (1) AU2002255961B2 (https=)
CA (1) CA2455915C (https=)
DE (1) DE60236921D1 (https=)
DK (1) DK1383919T3 (https=)
ES (1) ES2352228T3 (https=)
WO (1) WO2002079517A1 (https=)

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US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
EP1861407A1 (en) 2005-03-24 2007-12-05 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
WO2007044622A1 (en) 2005-10-07 2007-04-19 Yale University Use of mif and mif pathway agonists
US9238689B2 (en) 2011-07-15 2016-01-19 Morpho Sys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
CA2842195A1 (en) 2011-07-18 2013-01-24 Immunomedics, Inc. Fty720 increases cd74 expression and sensitizes cancer cells to anti-cd74 antibody-mediated cell death
JP2014530360A (ja) 2011-10-07 2014-11-17 バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒ Ｈｅａｌｔｈｃａｒｅ ＳＡ 診断マーカーとしてのｏｘＭＩＦ
WO2014127200A1 (en) 2013-02-15 2014-08-21 Immunomedics, Inc. Chimeric and humanized anti-histone antibodies
WO2015051330A1 (en) 2013-10-03 2015-04-09 Oregon Health & Science University RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II α1 DOMAINS
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
US10351621B2 (en) 2014-06-24 2019-07-16 Immunomedics, Inc. Anti-histone therapy in acute kidney injury
WO2015200260A1 (en) 2014-06-24 2015-12-30 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
US11397182B2 (en) 2014-10-07 2022-07-26 Cornell University Methods for prognosing and preventing metastatic liver disease
WO2017070569A1 (en) * 2015-10-23 2017-04-27 Oregon Health & Science University Compounds that bind macrophage migration inhibitory factor
WO2018187074A1 (en) 2017-04-03 2018-10-11 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
CN114668832A (zh) * 2022-04-27 2022-06-28 西安市第一医院 Mif及其受体cd74制备调控细胞功能和分裂增殖药物中的应用

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EP1383919A4 (en) 2004-12-01
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US20090263404A1 (en) 2009-10-22
US20140178403A1 (en) 2014-06-26
US20060024754A1 (en) 2006-02-02
US20120039914A1 (en) 2012-02-16
ES2352228T3 (es) 2011-02-16
US20080146507A1 (en) 2008-06-19
JP2004532839A (ja) 2004-10-28
US20110020321A1 (en) 2011-01-27
DE60236921D1 (de) 2010-08-19
US8617822B2 (en) 2013-12-31
EP1383919A1 (en) 2004-01-28
ATE473294T1 (de) 2010-07-15
US7741057B2 (en) 2010-06-22
US9221903B2 (en) 2015-12-29
US8779099B2 (en) 2014-07-15
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US20180105593A1 (en) 2018-04-19
US20160152708A1 (en) 2016-06-02
US20030013122A1 (en) 2003-01-16
CA2455915A1 (en) 2002-10-10
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JP4202763B2 (ja) 2008-12-24
CA2455915C (en) 2013-05-14

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