DK1381615T3 - Antidepressive indoltetrahydropyridinderivater af 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indol - Google Patents
Antidepressive indoltetrahydropyridinderivater af 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indolInfo
- Publication number
- DK1381615T3 DK1381615T3 DK02728990T DK02728990T DK1381615T3 DK 1381615 T3 DK1381615 T3 DK 1381615T3 DK 02728990 T DK02728990 T DK 02728990T DK 02728990 T DK02728990 T DK 02728990T DK 1381615 T3 DK1381615 T3 DK 1381615T3
- Authority
- DK
- Denmark
- Prior art keywords
- indole
- dioxino
- antidepressant
- dihydro
- tetrahydropyridine derivatives
- Prior art date
Links
- KMGBGQRYJWFNML-UHFFFAOYSA-N 1h-indole;1,2,3,4-tetrahydropyridine Chemical class C1CNC=CC1.C1=CC=C2NC=CC2=C1 KMGBGQRYJWFNML-UHFFFAOYSA-N 0.000 title 1
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 206010001584 alcohol abuse Diseases 0.000 abstract 1
- 208000025746 alcohol use disease Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000001272 cocaine abuse Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28657501P | 2001-04-26 | 2001-04-26 | |
| PCT/US2002/013118 WO2002088146A2 (en) | 2001-04-26 | 2002-04-25 | ANTIDEPRESSANT INDOLETETRAHYDROPYRIDINE DERIVATIVES OF 2,3-DIHYDRO-7H-[1,4]DIOXINO[2,3-e]INDOLE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1381615T3 true DK1381615T3 (da) | 2004-11-29 |
Family
ID=23099224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02728990T DK1381615T3 (da) | 2001-04-26 | 2002-04-25 | Antidepressive indoltetrahydropyridinderivater af 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6593350B2 (pt) |
| EP (1) | EP1381615B1 (pt) |
| JP (1) | JP2004533437A (pt) |
| CN (1) | CN1267438C (pt) |
| AT (1) | ATE279418T1 (pt) |
| AU (1) | AU2002259010A1 (pt) |
| BR (1) | BR0209336A (pt) |
| CA (1) | CA2445583A1 (pt) |
| DE (1) | DE60201592T2 (pt) |
| DK (1) | DK1381615T3 (pt) |
| ES (1) | ES2230490T3 (pt) |
| MX (1) | MXPA03009739A (pt) |
| PT (1) | PT1381615E (pt) |
| WO (1) | WO2002088146A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939877B2 (en) * | 2002-09-12 | 2005-09-06 | Wyeth | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans |
| US20040192730A1 (en) * | 2003-03-13 | 2004-09-30 | Dynogen Pharmaceuticals, Inc. | Methods of using compounds with combined 5-HT1A and SSRI activities as-needed to treat sexual dysfunction |
| CN100402534C (zh) * | 2006-11-09 | 2008-07-16 | 东南大学 | 一种三环类化合物及其在制药中的应用 |
| ES2604667T3 (es) | 2009-06-17 | 2017-03-08 | Vertex Pharmaceuticals Incorporated | Inhibidores de la replicación de virus de influenza |
| CA2822057A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CN102178056B (zh) * | 2011-05-05 | 2012-08-08 | 王宏雁 | 二氢吡啶包合物 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
| EP3068776B1 (en) | 2013-11-13 | 2019-05-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991013872A1 (en) | 1990-03-15 | 1991-09-19 | The Upjohn Company | Therapeutically useful heterocyclic indole compounds |
| DE4135474A1 (de) | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
| DE4140540A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
| US5741789A (en) | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| GB9526495D0 (en) | 1995-12-23 | 1996-02-28 | Knoll Ag | Therapeutic agents |
| US5869490A (en) | 1996-10-15 | 1999-02-09 | American Home Products Corporation | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one |
| GB9627005D0 (en) | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
| GB9704948D0 (en) | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US6458802B1 (en) * | 2001-03-14 | 2002-10-01 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline |
-
2002
- 2002-04-24 US US10/131,339 patent/US6593350B2/en not_active Expired - Fee Related
- 2002-04-25 AT AT02728990T patent/ATE279418T1/de not_active IP Right Cessation
- 2002-04-25 WO PCT/US2002/013118 patent/WO2002088146A2/en active IP Right Grant
- 2002-04-25 DK DK02728990T patent/DK1381615T3/da active
- 2002-04-25 ES ES02728990T patent/ES2230490T3/es not_active Expired - Lifetime
- 2002-04-25 MX MXPA03009739A patent/MXPA03009739A/es active IP Right Grant
- 2002-04-25 BR BR0209336-7A patent/BR0209336A/pt not_active IP Right Cessation
- 2002-04-25 DE DE60201592T patent/DE60201592T2/de not_active Expired - Fee Related
- 2002-04-25 CA CA002445583A patent/CA2445583A1/en not_active Abandoned
- 2002-04-25 CN CNB028086228A patent/CN1267438C/zh not_active Expired - Fee Related
- 2002-04-25 PT PT02728990T patent/PT1381615E/pt unknown
- 2002-04-25 EP EP02728990A patent/EP1381615B1/en not_active Expired - Lifetime
- 2002-04-25 AU AU2002259010A patent/AU2002259010A1/en not_active Abandoned
- 2002-04-25 JP JP2002585444A patent/JP2004533437A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1381615A2 (en) | 2004-01-21 |
| DE60201592T2 (de) | 2005-02-17 |
| MXPA03009739A (es) | 2005-03-07 |
| DE60201592D1 (de) | 2004-11-18 |
| EP1381615B1 (en) | 2004-10-13 |
| CN1267438C (zh) | 2006-08-02 |
| CA2445583A1 (en) | 2002-11-07 |
| BR0209336A (pt) | 2004-06-15 |
| WO2002088146A2 (en) | 2002-11-07 |
| US6593350B2 (en) | 2003-07-15 |
| ES2230490T3 (es) | 2005-05-01 |
| CN1503800A (zh) | 2004-06-09 |
| PT1381615E (pt) | 2005-02-28 |
| AU2002259010A1 (en) | 2002-11-11 |
| US20020183352A1 (en) | 2002-12-05 |
| ATE279418T1 (de) | 2004-10-15 |
| JP2004533437A (ja) | 2004-11-04 |
| WO2002088146A3 (en) | 2003-02-13 |
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