DK1381351T3 - Fremgangsmåde til kontinuerlig fremstilling af inhalerbare medikamenter - Google Patents
Fremgangsmåde til kontinuerlig fremstilling af inhalerbare medikamenterInfo
- Publication number
- DK1381351T3 DK1381351T3 DK02722039T DK02722039T DK1381351T3 DK 1381351 T3 DK1381351 T3 DK 1381351T3 DK 02722039 T DK02722039 T DK 02722039T DK 02722039 T DK02722039 T DK 02722039T DK 1381351 T3 DK1381351 T3 DK 1381351T3
- Authority
- DK
- Denmark
- Prior art keywords
- continuous preparation
- inhalable medications
- inhalable
- medications
- continuous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0063—Control or regulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
- B01F25/31324—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices arranged concentrically
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3012—Interdigital streams, e.g. lamellae
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F2025/91—Direction of flow or arrangement of feed and discharge openings
- B01F2025/917—Laminar or parallel flow, i.e. every point of the flow moves in layers which do not intermix
- B01F2025/9171—Parallel flow, i.e. every point of the flow moves in parallel layers where intermixing can occur by diffusion or which do not intermix; Focusing, i.e. compressing parallel layers without intermixing them
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00858—Aspects relating to the size of the reactor
- B01J2219/0086—Dimensions of the flow channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00873—Heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00984—Residence time
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/02—Apparatus characterised by their chemically-resistant properties
- B01J2219/0204—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components
- B01J2219/0245—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components of synthetic organic material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10119718A DE10119718A1 (de) | 2001-04-21 | 2001-04-21 | Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff |
PCT/EP2002/000885 WO2002085329A1 (de) | 2001-04-21 | 2002-01-29 | Verfahren zur kontinuierlichen herstellung inhalierfähiger arzneistoffe |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1381351T3 true DK1381351T3 (da) | 2004-11-29 |
Family
ID=7682321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02722039T DK1381351T3 (da) | 2001-04-21 | 2002-01-29 | Fremgangsmåde til kontinuerlig fremstilling af inhalerbare medikamenter |
Country Status (12)
Country | Link |
---|---|
US (3) | US6663848B2 (ja) |
EP (2) | EP1470814A1 (ja) |
JP (1) | JP2004528899A (ja) |
AR (1) | AR033240A1 (ja) |
AT (1) | ATE279178T1 (ja) |
DE (2) | DE10119718A1 (ja) |
DK (1) | DK1381351T3 (ja) |
ES (1) | ES2231684T3 (ja) |
PT (1) | PT1381351E (ja) |
TR (1) | TR200402820T4 (ja) |
TW (1) | TW559562B (ja) |
WO (1) | WO2002085329A1 (ja) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
US7718099B2 (en) | 2002-04-25 | 2010-05-18 | Tosoh Corporation | Fine channel device, fine particle producing method and solvent extraction method |
DE10244795A1 (de) * | 2002-09-26 | 2004-04-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
US7208485B2 (en) * | 2003-01-13 | 2007-04-24 | Chemagis Ltd. | Crystalline forms of halobetasol propionate |
US20040138192A1 (en) * | 2003-01-13 | 2004-07-15 | Chemagis Ltd. | Crystalline forms of halobetasol propionate |
BRPI0506610A (pt) * | 2004-02-03 | 2007-05-02 | Chemagis Ltd | montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico |
US7934865B2 (en) | 2004-02-17 | 2011-05-03 | Ehrfeld Mikrotechnik Bts Gmbh | Micromixer |
DE102005003965A1 (de) * | 2005-01-27 | 2006-08-10 | Ehrfeld Mikrotechnik Gmbh | Mikromischer |
DE102004012093A1 (de) * | 2004-03-05 | 2005-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Merkanaldüse |
GB0502398D0 (en) * | 2005-02-04 | 2005-03-16 | Q Chip Ltd | Device and method for producing spherical segmented flow |
DE102004049730B4 (de) * | 2004-10-11 | 2007-05-03 | Technische Universität Darmstadt | Mikrokapillarreaktor und Verfahren zum kontrollierten Vermengen von nicht homogen mischbaren Fluiden unter Verwendung dieses Mikrokapillarreaktors |
US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070178049A1 (en) * | 2005-12-20 | 2007-08-02 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
CA2642577A1 (en) * | 2006-02-15 | 2007-08-23 | Tika Lakemedel Ab | Methods of manufacturing corticosteroid solutions |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
EP2266690A1 (en) * | 2006-05-11 | 2010-12-29 | Corning Incorporated | High throughput thermally tempered microreactor devices and methods |
GB0619442D0 (en) * | 2006-10-02 | 2006-11-08 | Q Chip Ltd | Beads for use in reactions for the amplification and/or synthesis of a polynucleotide |
DE102008037025C5 (de) * | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
US20100294986A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Supercritical fluid facilitated particle formation in microfluidic systems |
US20100298602A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Systems and methods for microfluidic crystallization |
US8589344B2 (en) * | 2009-11-30 | 2013-11-19 | Red Hat, Inc. | Systems and methods for generating iterated distributions of data in a hierarchical database |
JP5749987B2 (ja) * | 2011-06-22 | 2015-07-15 | 株式会社神戸製鋼所 | 液体混合方法及び装置 |
DE102011078979A1 (de) * | 2011-07-11 | 2013-01-17 | Böwe Systec Gmbh | Vorrichtung und Verfahren zum Transport einer Hülle |
JP5864236B2 (ja) * | 2011-12-07 | 2016-02-17 | 東芝機械株式会社 | マイクロミキサー、マイクロミキサーエレメントおよびその製造方法 |
JP6006969B2 (ja) * | 2012-04-24 | 2016-10-12 | 東芝機械株式会社 | マイクロミキサー、マイクロミキサーエレメントおよびその製造方法 |
DE102012221219B4 (de) * | 2012-11-20 | 2014-05-28 | Jesalis Pharma Gmbh | Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel |
US20180161748A1 (en) * | 2015-05-29 | 2018-06-14 | Shoei Chemical Inc. | Fluid-segmentation device, flow mixing and segmentation device, continuous-flow reactor system, and method for producing nanoparticles |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1794084C3 (de) * | 1968-09-04 | 1973-10-25 | Union Rheinische Braunkohlen Kraftstoff Ag, 5047 Wesseling | Vorrichtung zum kontinuierlichen Gewinnen von Kristallen aus einer Schmelze oder Losung |
US5394706A (en) * | 1993-05-20 | 1995-03-07 | Waterworks International, Inc. | Freeze crystallization for the removal of water from a solution of dissolved solids |
WO1998033585A1 (en) * | 1997-02-05 | 1998-08-06 | California Institute Of Technology | Microfluidic sub-millisecond mixers |
US6045703A (en) * | 1998-06-15 | 2000-04-04 | Union Carbide Chemicals & Plastics Technology Corporation | Separation processes |
DE19917156B4 (de) | 1999-04-16 | 2006-01-19 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Verfahren zur Herstellung einer Wasser-in-Dieselöl-Emulsion als Kraftstoff sowie dessen Verwendungen |
GB9919693D0 (en) * | 1999-08-19 | 1999-10-20 | Rhone Poulenc Rorer Ltd | Process |
ATE342717T1 (de) * | 1999-11-30 | 2006-11-15 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe |
DE10005549A1 (de) * | 2000-02-09 | 2001-09-06 | Cpc Cellular Process Chemistry | Mikroreaktor für Reaktionsmedien in Form einer Suspension |
JP4182273B2 (ja) * | 2000-06-27 | 2008-11-19 | 住友化学株式会社 | ε−カプロラクタムの製造方法 |
US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
-
2001
- 2001-04-21 DE DE10119718A patent/DE10119718A1/de not_active Ceased
-
2002
- 2002-01-29 PT PT02722039T patent/PT1381351E/pt unknown
- 2002-01-29 JP JP2002582903A patent/JP2004528899A/ja active Pending
- 2002-01-29 TR TR2004/02820T patent/TR200402820T4/xx unknown
- 2002-01-29 AT AT02722039T patent/ATE279178T1/de active
- 2002-01-29 DE DE2002501306 patent/DE50201306D1/de not_active Expired - Lifetime
- 2002-01-29 ES ES02722039T patent/ES2231684T3/es not_active Expired - Lifetime
- 2002-01-29 WO PCT/EP2002/000885 patent/WO2002085329A1/de active IP Right Grant
- 2002-01-29 EP EP04017279A patent/EP1470814A1/de not_active Ceased
- 2002-01-29 EP EP02722039A patent/EP1381351B1/de not_active Expired - Lifetime
- 2002-01-29 DK DK02722039T patent/DK1381351T3/da active
- 2002-04-04 TW TW091106833A patent/TW559562B/zh active
- 2002-04-18 US US10/125,044 patent/US6663848B2/en not_active Expired - Lifetime
- 2002-04-19 AR ARP020101437A patent/AR033240A1/es not_active Withdrawn
-
2003
- 2003-05-19 US US10/340,314 patent/US7066171B2/en not_active Expired - Lifetime
-
2005
- 2005-06-30 US US11/173,772 patent/US7249599B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
TR200402820T4 (tr) | 2004-11-22 |
DE10119718A1 (de) | 2002-10-31 |
ES2231684T3 (es) | 2005-05-16 |
EP1470814A1 (de) | 2004-10-27 |
AR033240A1 (es) | 2003-12-10 |
US20050244314A1 (en) | 2005-11-03 |
ATE279178T1 (de) | 2004-10-15 |
PT1381351E (pt) | 2005-02-28 |
WO2002085329A1 (de) | 2002-10-31 |
US20030175187A1 (en) | 2003-09-18 |
US7249599B2 (en) | 2007-07-31 |
DE50201306D1 (de) | 2004-11-18 |
US7066171B2 (en) | 2006-06-27 |
EP1381351A1 (de) | 2004-01-21 |
EP1381351B1 (de) | 2004-10-13 |
TW559562B (en) | 2003-11-01 |
US20030015194A1 (en) | 2003-01-23 |
JP2004528899A (ja) | 2004-09-24 |
US6663848B2 (en) | 2003-12-16 |
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