DK136861B - Analogifremgangsmåde til fremstilling af 5-, 6-, 7- eller 8-(2-hydroxy-3-alkylamino)propoxycarbostyriler eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 5-, 6-, 7- eller 8-(2-hydroxy-3-alkylamino)propoxycarbostyriler eller syreadditionssalte deraf.

Info

Publication number
DK136861B
DK136861B DK663673AA DK663673A DK136861B DK 136861 B DK136861 B DK 136861B DK 663673A A DK663673A A DK 663673AA DK 663673 A DK663673 A DK 663673A DK 136861 B DK136861 B DK 136861B
Authority
DK
Denmark
Prior art keywords
propoxycarbostyriles
alkylamino
hydroxy
preparation
acid addition
Prior art date
Application number
DK663673AA
Other languages
Danish (da)
English (en)
Other versions
DK136861C (ja
Inventor
Kazuyuki Nakagawa
Shiro Yoshizaki
Nanami Murakami
Hideo Mori
Original Assignee
Otsuka Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Phamaceutical Co Ltd filed Critical Otsuka Phamaceutical Co Ltd
Publication of DK136861B publication Critical patent/DK136861B/da
Application granted granted Critical
Publication of DK136861C publication Critical patent/DK136861C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK663673AA 1972-12-14 1973-12-07 Analogifremgangsmåde til fremstilling af 5-, 6-, 7- eller 8-(2-hydroxy-3-alkylamino)propoxycarbostyriler eller syreadditionssalte deraf. DK136861B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP47125857A JPS5239035B2 (ja) 1972-12-14 1972-12-14

Publications (2)

Publication Number Publication Date
DK136861B true DK136861B (da) 1977-12-05
DK136861C DK136861C (ja) 1978-05-08

Family

ID=14920647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK663673AA DK136861B (da) 1972-12-14 1973-12-07 Analogifremgangsmåde til fremstilling af 5-, 6-, 7- eller 8-(2-hydroxy-3-alkylamino)propoxycarbostyriler eller syreadditionssalte deraf.

Country Status (11)

Country Link
US (1) US3953456A (ja)
JP (1) JPS5239035B2 (ja)
AR (1) AR197270A1 (ja)
BE (1) BE808593A (ja)
CA (1) CA1022555A (ja)
CH (1) CH589060A5 (ja)
DE (1) DE2362278C2 (ja)
DK (1) DK136861B (ja)
ES (1) ES421430A1 (ja)
FR (1) FR2210408B1 (ja)
NL (1) NL166931C (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
GB1504424A (en) * 1975-08-09 1978-03-22 Beecham Group Ltd Isoquinoline-derived aminoethers
CH619453A5 (ja) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
US4139537A (en) * 1976-06-29 1979-02-13 Cooper Laboratories, Inc. 3-Aryloxy-1-(2- or 4-iminodihydro-1-pyridyl)-2-propanol antiarrhythmic compounds
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
DE2934609A1 (de) 1979-08-28 1981-03-12 Cassella Ag, 6000 Frankfurt Tetrahydrochinolinderivate, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen.
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
ES2048108B1 (es) * 1992-07-17 1994-10-01 Lusochimica Spa Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.
CN101622243B (zh) 2007-02-28 2013-12-04 旭化成制药株式会社 磺酰胺衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
GB1047927A (en) * 1964-03-09 1966-11-09 Ici Ltd Alkanolamine derivatives
GB1079989A (en) * 1965-09-28 1967-08-16 Ici Ltd Carbocyclic propanolamines

Also Published As

Publication number Publication date
AU6338573A (en) 1975-07-10
FR2210408A1 (ja) 1974-07-12
DE2362278A1 (de) 1974-06-20
JPS4981372A (ja) 1974-08-06
DE2362278C2 (de) 1983-03-24
DK136861C (ja) 1978-05-08
ES421430A1 (es) 1976-05-01
NL166931B (nl) 1981-05-15
NL7317090A (ja) 1974-06-18
NL166931C (nl) 1981-10-15
CA1022555A (en) 1977-12-13
JPS5239035B2 (ja) 1977-10-03
CH589060A5 (ja) 1977-06-30
AR197270A1 (es) 1974-03-22
FR2210408B1 (ja) 1977-03-11
US3953456A (en) 1976-04-27
BE808593A (fr) 1974-03-29

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