DK136647B - Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf.

Info

Publication number
DK136647B
DK136647B DK649370AA DK649370A DK136647B DK 136647 B DK136647 B DK 136647B DK 649370A A DK649370A A DK 649370AA DK 649370 A DK649370 A DK 649370A DK 136647 B DK136647 B DK 136647B
Authority
DK
Denmark
Prior art keywords
benzodiazepin
iodo
fluorophenyl
dihydro
methyl
Prior art date
Application number
DK649370AA
Other languages
Danish (da)
English (en)
Other versions
DK136647C (bg
Inventor
George Francis Field
Leo Henryk Sternbach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to DK86676A priority Critical patent/DK86676A/da
Publication of DK136647B publication Critical patent/DK136647B/da
Application granted granted Critical
Publication of DK136647C publication Critical patent/DK136647C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/28Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK649370AA 1970-06-01 1970-12-21 Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf. DK136647B (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK86676A DK86676A (da) 1970-06-01 1976-03-01 Iodsubstituerede benzodiazepinderivater og salte deraf samt preparater indeholdende sadanne derivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4253370A 1970-06-01 1970-06-01

Publications (2)

Publication Number Publication Date
DK136647B true DK136647B (da) 1977-11-07
DK136647C DK136647C (bg) 1978-04-17

Family

ID=21922438

Family Applications (1)

Application Number Title Priority Date Filing Date
DK649370AA DK136647B (da) 1970-06-01 1970-12-21 Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf.

Country Status (15)

Country Link
AR (1) AR193050A1 (bg)
BE (1) BE760510A (bg)
BG (3) BG18188A3 (bg)
CH (2) CH561684A5 (bg)
DE (1) DE2062927A1 (bg)
DK (1) DK136647B (bg)
ES (1) ES386685A1 (bg)
FR (1) FR2093923B1 (bg)
GB (1) GB1332699A (bg)
IE (1) IE35428B1 (bg)
IL (1) IL35885A (bg)
NL (1) NL7018577A (bg)
NO (1) NO130681C (bg)
PH (1) PH9829A (bg)
SE (2) SE385298B (bg)

Also Published As

Publication number Publication date
IL35885A (en) 1974-05-16
NO130681B (bg) 1974-10-14
SE7513327L (sv) 1975-11-26
NO130681C (bg) 1975-01-22
CH549586A (de) 1974-05-31
PH9829A (en) 1976-04-02
IE35428B1 (en) 1976-02-18
BG18188A3 (bg) 1974-09-02
FR2093923B1 (bg) 1974-05-24
NL7018577A (bg) 1971-12-03
AR193050A1 (es) 1973-03-30
CH561684A5 (bg) 1975-05-15
FR2093923A1 (bg) 1972-02-04
DK136647C (bg) 1978-04-17
ES386685A1 (es) 1973-03-16
BG18187A3 (bg) 1974-09-02
BG18186A3 (bg) 1974-09-02
DE2062927A1 (de) 1971-12-16
GB1332699A (en) 1973-10-03
BE760510A (fr) 1971-06-18
SE385298B (sv) 1976-06-21
IL35885A0 (en) 1971-04-28
IE35428L (en) 1971-12-01

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