DK136647B - Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf.

Info

Publication number
DK136647B
DK136647B DK649370AA DK649370A DK136647B DK 136647 B DK136647 B DK 136647B DK 649370A A DK649370A A DK 649370AA DK 649370 A DK649370 A DK 649370A DK 136647 B DK136647 B DK 136647B
Authority
DK
Denmark
Prior art keywords
benzodiazepin
iodo
fluorophenyl
dihydro
methyl
Prior art date
Application number
DK649370AA
Other languages
English (en)
Other versions
DK136647C (da
Inventor
George Francis Field
Leo Henryk Sternbach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to DK86676A priority Critical patent/DK86676A/da
Publication of DK136647B publication Critical patent/DK136647B/da
Application granted granted Critical
Publication of DK136647C publication Critical patent/DK136647C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK649370AA 1970-06-01 1970-12-21 Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf. DK136647B (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK86676A DK86676A (da) 1970-06-01 1976-03-01 Iodsubstituerede benzodiazepinderivater og salte deraf samt preparater indeholdende sadanne derivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4253370A 1970-06-01 1970-06-01

Publications (2)

Publication Number Publication Date
DK136647B true DK136647B (da) 1977-11-07
DK136647C DK136647C (da) 1978-04-17

Family

ID=21922438

Family Applications (1)

Application Number Title Priority Date Filing Date
DK649370AA DK136647B (da) 1970-06-01 1970-12-21 Analogifremgangsmåde til fremstilling af 5-(2-fluorphenyl)-7-iod-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-on eller syreadditionssalte deraf.

Country Status (15)

Country Link
AR (1) AR193050A1 (da)
BE (1) BE760510A (da)
BG (3) BG18188A3 (da)
CH (2) CH549586A (da)
DE (1) DE2062927A1 (da)
DK (1) DK136647B (da)
ES (1) ES386685A1 (da)
FR (1) FR2093923B1 (da)
GB (1) GB1332699A (da)
IE (1) IE35428B1 (da)
IL (1) IL35885A (da)
NL (1) NL7018577A (da)
NO (1) NO130681C (da)
PH (1) PH9829A (da)
SE (2) SE385298B (da)

Also Published As

Publication number Publication date
AR193050A1 (es) 1973-03-30
IE35428L (en) 1971-12-01
IL35885A0 (en) 1971-04-28
NO130681B (da) 1974-10-14
IE35428B1 (en) 1976-02-18
DE2062927A1 (de) 1971-12-16
BG18186A3 (da) 1974-09-02
SE385298B (sv) 1976-06-21
NL7018577A (da) 1971-12-03
CH549586A (de) 1974-05-31
SE7513327L (sv) 1975-11-26
IL35885A (en) 1974-05-16
BG18188A3 (da) 1974-09-02
FR2093923B1 (da) 1974-05-24
ES386685A1 (es) 1973-03-16
CH561684A5 (da) 1975-05-15
PH9829A (en) 1976-04-02
BG18187A3 (da) 1974-09-02
FR2093923A1 (da) 1972-02-04
GB1332699A (en) 1973-10-03
DK136647C (da) 1978-04-17
NO130681C (da) 1975-01-22
BE760510A (fr) 1971-06-18

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