DK1347960T3 - Fremgangsmåde til fremstilling af (+/-) trans-4-p-fluorphenyl-3-hydromethyl-1-methylpiperidin - Google Patents
Fremgangsmåde til fremstilling af (+/-) trans-4-p-fluorphenyl-3-hydromethyl-1-methylpiperidinInfo
- Publication number
- DK1347960T3 DK1347960T3 DK01901146T DK01901146T DK1347960T3 DK 1347960 T3 DK1347960 T3 DK 1347960T3 DK 01901146 T DK01901146 T DK 01901146T DK 01901146 T DK01901146 T DK 01901146T DK 1347960 T3 DK1347960 T3 DK 1347960T3
- Authority
- DK
- Denmark
- Prior art keywords
- fluorophenyl
- trans
- hydromethyl
- methylpiperidine
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2001/000049 WO2002053537A1 (fr) | 2001-01-04 | 2001-01-04 | Procede de preparation de (?)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1347960T3 true DK1347960T3 (da) | 2005-03-21 |
Family
ID=8164242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01901146T DK1347960T3 (da) | 2001-01-04 | 2001-01-04 | Fremgangsmåde til fremstilling af (+/-) trans-4-p-fluorphenyl-3-hydromethyl-1-methylpiperidin |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6881845B2 (fr) |
| EP (1) | EP1347960B1 (fr) |
| JP (1) | JP2004520333A (fr) |
| KR (1) | KR20030067742A (fr) |
| AT (1) | ATE282594T1 (fr) |
| BR (1) | BR0116721A (fr) |
| CA (1) | CA2433605A1 (fr) |
| DE (1) | DE60107292T2 (fr) |
| DK (1) | DK1347960T3 (fr) |
| ES (1) | ES2232588T3 (fr) |
| IL (1) | IL156768A0 (fr) |
| MX (1) | MXPA03006057A (fr) |
| NO (1) | NO20033049L (fr) |
| NZ (1) | NZ526874A (fr) |
| PT (1) | PT1347960E (fr) |
| TW (1) | TW593279B (fr) |
| WO (1) | WO2002053537A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9087301A (en) * | 2000-09-11 | 2002-03-26 | Sepracor Inc | Ligands for monoamine receptors and transporters, and methods of use thereof |
| DE10240026A1 (de) * | 2002-08-27 | 2004-03-11 | Merck Patent Gmbh | Verfahren zur Herstellung von Monoalkylaminoketonen |
| WO2004043921A1 (fr) * | 2002-11-11 | 2004-05-27 | Natco Pharma Limited | Nouveau procede de preparation de 4-aryl-3-hydroxymethyl-1-methylpiperidines |
| WO2005063707A1 (fr) * | 2003-12-26 | 2005-07-14 | Natco Pharma Limited | Procede enantiospecifique permettant de preparer un intermediaire de paroxetine |
| WO2007089193A1 (fr) * | 2006-02-02 | 2007-08-09 | Astrazeneca Ab | Procédé de synthèse du 2-hydroxy-3-[5-(morpholin-4-ylméthyl)pyridin-2-yl]1h-indole-5-carbonitrile sous forme de base libre ou de ses sels |
| US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
| WO2022269643A1 (fr) * | 2021-06-25 | 2022-12-29 | Vihita Chem Private Limited | Procédé amélioré pour la préparation d'un intermédiaire pour la paroxétine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| DE3680184D1 (de) | 1985-08-10 | 1991-08-14 | Beecham Group Plc | Verfahren zur herstellung von arylpiperidincarbinol. |
| DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
| JPH11505229A (ja) * | 1995-05-17 | 1999-05-18 | ノボ ノルディスク アクティーゼルスカブ | ４−アリール−ピペリジン誘導体を製造する方法 |
| DE69739561D1 (de) * | 1996-06-13 | 2009-10-15 | Sumitomo Chemical Co | Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung |
| AP9901698A0 (en) * | 1997-05-29 | 1999-12-31 | Smithkline Beecham Corp | Novel process. |
| AU6360999A (en) * | 1998-11-02 | 2000-05-22 | Synthon B.V. | Process for producing 4-arylpiperidine-3-carbinols and related compounds |
-
2001
- 2001-01-04 AT AT01901146T patent/ATE282594T1/de not_active IP Right Cessation
- 2001-01-04 BR BR0116721-9A patent/BR0116721A/pt not_active IP Right Cessation
- 2001-01-04 MX MXPA03006057A patent/MXPA03006057A/es not_active Application Discontinuation
- 2001-01-04 DK DK01901146T patent/DK1347960T3/da active
- 2001-01-04 NZ NZ526874A patent/NZ526874A/en unknown
- 2001-01-04 WO PCT/EP2001/000049 patent/WO2002053537A1/fr not_active Application Discontinuation
- 2001-01-04 US US10/250,519 patent/US6881845B2/en not_active Expired - Fee Related
- 2001-01-04 KR KR10-2003-7009058A patent/KR20030067742A/ko not_active Application Discontinuation
- 2001-01-04 EP EP01901146A patent/EP1347960B1/fr not_active Expired - Lifetime
- 2001-01-04 PT PT01901146T patent/PT1347960E/pt unknown
- 2001-01-04 IL IL15676801A patent/IL156768A0/xx unknown
- 2001-01-04 DE DE60107292T patent/DE60107292T2/de not_active Expired - Fee Related
- 2001-01-04 CA CA002433605A patent/CA2433605A1/fr not_active Abandoned
- 2001-01-04 JP JP2002554656A patent/JP2004520333A/ja not_active Abandoned
- 2001-01-04 ES ES01901146T patent/ES2232588T3/es not_active Expired - Lifetime
- 2001-02-27 TW TW090104450A patent/TW593279B/zh not_active IP Right Cessation
-
2003
- 2003-07-03 NO NO20033049A patent/NO20033049L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030067742A (ko) | 2003-08-14 |
| EP1347960B1 (fr) | 2004-11-17 |
| IL156768A0 (en) | 2004-02-08 |
| DE60107292D1 (de) | 2004-12-23 |
| WO2002053537A8 (fr) | 2002-08-08 |
| WO2002053537A1 (fr) | 2002-07-11 |
| NO20033049L (no) | 2003-08-18 |
| US20040215020A1 (en) | 2004-10-28 |
| NZ526874A (en) | 2005-07-29 |
| EP1347960A1 (fr) | 2003-10-01 |
| ES2232588T3 (es) | 2005-06-01 |
| NO20033049D0 (no) | 2003-07-03 |
| ATE282594T1 (de) | 2004-12-15 |
| TW593279B (en) | 2004-06-21 |
| US6881845B2 (en) | 2005-04-19 |
| DE60107292T2 (de) | 2005-12-01 |
| PT1347960E (pt) | 2005-03-31 |
| BR0116721A (pt) | 2003-12-23 |
| MXPA03006057A (es) | 2004-01-26 |
| JP2004520333A (ja) | 2004-07-08 |
| CA2433605A1 (fr) | 2002-07-11 |
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