DK1313508T5 - Kombination indeholdende et antifolat og methylmalonsyresænkende middel - Google Patents
Kombination indeholdende et antifolat og methylmalonsyresænkende middel Download PDFInfo
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- DK1313508T5 DK1313508T5 DK01948214.0T DK01948214T DK1313508T5 DK 1313508 T5 DK1313508 T5 DK 1313508T5 DK 01948214 T DK01948214 T DK 01948214T DK 1313508 T5 DK1313508 T5 DK 1313508T5
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
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| PCT/US2001/014860 WO2002002093A2 (en) | 2000-06-30 | 2001-06-15 | Combination containing an antifolate and methylmalonic acid lowering agent |
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| JP5899241B2 (ja) | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
| WO2013179248A1 (en) | 2012-05-30 | 2013-12-05 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of pemetrexed |
| CA2948601A1 (en) * | 2014-06-04 | 2015-12-10 | Thomas Helledays Stiftelse For Medicinsk Forskning | Mth1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| CN108135902A (zh) * | 2015-07-30 | 2018-06-08 | 爱科谱迅病理研究公司 | 用于最优癌症治疗的定量FR-α和GART蛋白质 |
| EP3386546B1 (en) * | 2015-12-07 | 2024-09-04 | General Oncology, Inc. | Combination for the effective treatment of metastatic cancer in patients |
| WO2018031967A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| CA3033077C (en) | 2016-08-12 | 2024-06-18 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| EP3565549B1 (en) | 2017-01-09 | 2022-03-09 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| EP3737376B1 (en) | 2018-01-09 | 2024-04-17 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human diseases |
| CN111954529A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化氨甲蝶呤及其用途 |
| WO2019157146A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| JP7490239B2 (ja) | 2018-02-07 | 2024-05-27 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | ガンマポリグルタミン酸化ペメトレキセドおよびその使用 |
| US12246015B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| WO2019157120A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated tetrahydrofolates and uses thereof |
| JP7491572B2 (ja) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化ペメトレキセドおよびその使用 |
| WO2019157123A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
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| WO2023177894A1 (en) | 2022-03-18 | 2023-09-21 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and an antimetabolite agent |
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2001
- 2001-06-15 JP JP2002506715A patent/JP5102928B2/ja not_active Expired - Lifetime
- 2001-06-15 AT AT01948214T patent/ATE359823T1/de active
- 2001-06-15 EP EP01948214A patent/EP1313508B1/en not_active Expired - Lifetime
- 2001-06-15 DE DE60127970T patent/DE60127970T2/de not_active Expired - Lifetime
- 2001-06-15 ES ES01948214T patent/ES2284660T3/es not_active Expired - Lifetime
- 2001-06-15 WO PCT/US2001/014860 patent/WO2002002093A2/en not_active Ceased
- 2001-06-15 PT PT01948214T patent/PT1313508E/pt unknown
- 2001-06-15 DK DK01948214.0T patent/DK1313508T5/da active
- 2001-06-15 US US10/297,821 patent/US7053065B2/en not_active Expired - Lifetime
- 2001-06-15 AU AU2001269688A patent/AU2001269688A1/en not_active Abandoned
-
2005
- 2005-11-29 US US11/288,807 patent/US20060079480A1/en not_active Abandoned
-
2007
- 2007-06-07 CY CY20071100756T patent/CY1107649T1/el unknown
- 2007-07-11 US US11/776,329 patent/US7772209B2/en not_active Expired - Fee Related
-
2010
- 2010-04-28 US US12/768,920 patent/US20100210583A1/en not_active Abandoned
-
2012
- 2012-06-27 JP JP2012144570A patent/JP5469706B2/ja not_active Expired - Lifetime
-
2013
- 2013-10-11 JP JP2013213276A patent/JP2014005304A/ja not_active Withdrawn
-
2015
- 2015-04-21 JP JP2015087012A patent/JP2015178501A/ja not_active Withdrawn
-
2016
- 2016-09-29 JP JP2016192173A patent/JP2017019852A/ja not_active Withdrawn
-
2018
- 2018-08-23 JP JP2018156677A patent/JP2018197265A/ja not_active Withdrawn
-
2020
- 2020-04-14 JP JP2020072098A patent/JP2020117536A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1313508B1 (en) | 2007-04-18 |
| DK1313508T3 (da) | 2007-08-06 |
| DE60127970T2 (de) | 2007-12-20 |
| DE60127970D1 (de) | 2007-05-31 |
| JP2012180381A (ja) | 2012-09-20 |
| AU2001269688A1 (en) | 2002-01-14 |
| WO2002002093A3 (en) | 2003-02-06 |
| ATE359823T1 (de) | 2007-05-15 |
| PT1313508E (pt) | 2007-06-21 |
| JP2014005304A (ja) | 2014-01-16 |
| EP1313508A2 (en) | 2003-05-28 |
| US7053065B2 (en) | 2006-05-30 |
| US20100210583A1 (en) | 2010-08-19 |
| JP2018197265A (ja) | 2018-12-13 |
| ES2284660T3 (es) | 2007-11-16 |
| WO2002002093A2 (en) | 2002-01-10 |
| JP5469706B2 (ja) | 2014-04-16 |
| US7772209B2 (en) | 2010-08-10 |
| JP2020117536A (ja) | 2020-08-06 |
| JP2015178501A (ja) | 2015-10-08 |
| JP5102928B2 (ja) | 2012-12-19 |
| US20030212038A1 (en) | 2003-11-13 |
| JP2004501964A (ja) | 2004-01-22 |
| CY1107649T1 (el) | 2013-04-18 |
| JP2017019852A (ja) | 2017-01-26 |
| US20060079480A1 (en) | 2006-04-13 |
| US20080032948A1 (en) | 2008-02-07 |
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