DK1289999T3 - Antitumoranaloger af ET-743 - Google Patents
Antitumoranaloger af ET-743Info
- Publication number
- DK1289999T3 DK1289999T3 DK01929813T DK01929813T DK1289999T3 DK 1289999 T3 DK1289999 T3 DK 1289999T3 DK 01929813 T DK01929813 T DK 01929813T DK 01929813 T DK01929813 T DK 01929813T DK 1289999 T3 DK1289999 T3 DK 1289999T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxy
- spiroamine
- protecting group
- bridge
- ecteinascidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Discharging, Photosensitive Material Shape In Electrophotography (AREA)
- Pyrane Compounds (AREA)
- Instruments For Viewing The Inside Of Hollow Bodies (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
| PCT/GB2001/002110 WO2001087894A1 (en) | 1999-05-14 | 2001-05-15 | Antitumoral analogs of et-743 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1289999T3 true DK1289999T3 (da) | 2005-03-14 |
Family
ID=34855248
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01929813T DK1289999T3 (da) | 2000-05-15 | 2001-05-15 | Antitumoranaloger af ET-743 |
| DK01929816T DK1287004T3 (da) | 2000-05-15 | 2001-05-15 | Syntetisk proces til fremstilling af en ecteinascidinforbindelse |
| DK04010399T DK1496060T3 (da) | 2000-05-15 | 2001-05-15 | Antitumoranaloger af ET 743 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01929816T DK1287004T3 (da) | 2000-05-15 | 2001-05-15 | Syntetisk proces til fremstilling af en ecteinascidinforbindelse |
| DK04010399T DK1496060T3 (da) | 2000-05-15 | 2001-05-15 | Antitumoranaloger af ET 743 |
Country Status (17)
| Country | Link |
|---|---|
| EP (3) | EP1287004B1 (pt) |
| KR (2) | KR100830717B1 (pt) |
| AT (2) | ATE300547T1 (pt) |
| AU (2) | AU783563B2 (pt) |
| DE (3) | DE60129753T2 (pt) |
| DK (3) | DK1289999T3 (pt) |
| EA (2) | EA006369B1 (pt) |
| ES (2) | ES2290583T3 (pt) |
| GB (1) | GB9918178D0 (pt) |
| HK (1) | HK1050193A1 (pt) |
| HU (1) | HU228789B1 (pt) |
| MX (1) | MXPA02010701A (pt) |
| NZ (2) | NZ532793A (pt) |
| PL (2) | PL215769B1 (pt) |
| PT (3) | PT1496060E (pt) |
| SI (2) | SI1496060T1 (pt) |
| UA (1) | UA75597C2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1658848T3 (pl) | 2004-10-29 | 2007-12-31 | Pharma Mar Sa | Preparaty zawierające ekteinascydynę i disacharyd |
| KR100676325B1 (ko) * | 2005-03-15 | 2007-01-30 | 삼성전자주식회사 | 디스플레이장치 |
| KR100676324B1 (ko) * | 2005-03-15 | 2007-01-30 | 삼성전자주식회사 | 디스플레이장치 |
| KR100712667B1 (ko) * | 2006-04-11 | 2007-05-02 | 재단법인서울대학교산학협력재단 | 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법 |
| JP6037337B2 (ja) * | 2010-05-25 | 2016-12-07 | ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａ Ｍｒｓ，Ｓ．Ａ． | エクチナサイジン化合物の製造のための合成方法 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| WO2020105068A1 (en) * | 2018-11-24 | 2020-05-28 | Natco Pharma Limited | Process for the preparation of ecteinascidin derivative and its intermediate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| ATE69234T1 (de) * | 1986-06-09 | 1991-11-15 | Univ Illinois | Ekteinascidine 729, 743, 745, 759a, 759b and 770. |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
-
1999
- 1999-08-02 GB GBGB9918178.6A patent/GB9918178D0/en not_active Ceased
-
2001
- 2001-05-15 DE DE60129753T patent/DE60129753T2/de not_active Expired - Lifetime
- 2001-05-15 ES ES04010399T patent/ES2290583T3/es not_active Expired - Lifetime
- 2001-05-15 KR KR1020027015168A patent/KR100830717B1/ko active IP Right Review Request
- 2001-05-15 SI SI200130777T patent/SI1496060T1/sl unknown
- 2001-05-15 NZ NZ532793A patent/NZ532793A/en not_active IP Right Cessation
- 2001-05-15 MX MXPA02010701A patent/MXPA02010701A/es active IP Right Grant
- 2001-05-15 SI SI200130244T patent/SI1289999T1/xx unknown
- 2001-05-15 AU AU56493/01A patent/AU783563B2/en not_active Expired
- 2001-05-15 PL PL358258A patent/PL215769B1/pl unknown
- 2001-05-15 PT PT04010399T patent/PT1496060E/pt unknown
- 2001-05-15 DE DE60112286T patent/DE60112286T2/de not_active Expired - Lifetime
- 2001-05-15 DK DK01929813T patent/DK1289999T3/da active
- 2001-05-15 DE DE60107241T patent/DE60107241T2/de not_active Expired - Lifetime
- 2001-05-15 EA EA200201210A patent/EA006369B1/ru not_active IP Right Cessation
- 2001-05-15 AT AT01929816T patent/ATE300547T1/de active
- 2001-05-15 PT PT01929816T patent/PT1287004E/pt unknown
- 2001-05-15 NZ NZ521807A patent/NZ521807A/en not_active IP Right Cessation
- 2001-05-15 PL PL358143A patent/PL203745B1/pl unknown
- 2001-05-15 AU AU2001256496A patent/AU2001256496C1/en not_active Expired
- 2001-05-15 PT PT01929813T patent/PT1289999E/pt unknown
- 2001-05-15 UA UA20021210093A patent/UA75597C2/uk unknown
- 2001-05-15 EP EP01929816A patent/EP1287004B1/en not_active Expired - Lifetime
- 2001-05-15 DK DK01929816T patent/DK1287004T3/da active
- 2001-05-15 ES ES01929816T patent/ES2248319T3/es not_active Expired - Lifetime
- 2001-05-15 EP EP01929813A patent/EP1289999B1/en not_active Expired - Lifetime
- 2001-05-15 DK DK04010399T patent/DK1496060T3/da active
- 2001-05-15 HU HU0300648A patent/HU228789B1/hu unknown
- 2001-05-15 AT AT04010399T patent/ATE368671T1/de active
- 2001-05-15 EP EP04010399A patent/EP1496060B1/en not_active Expired - Lifetime
- 2001-05-15 KR KR1020027014555A patent/KR100777464B1/ko active IP Right Grant
- 2001-05-15 EA EA200201209A patent/EA006070B1/ru not_active IP Right Cessation
-
2003
- 2003-03-31 HK HK03102277A patent/HK1050193A1/xx not_active IP Right Cessation
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