DK128563B - 4,6-0-Alkyliden-β-D-glucopyranoser til anvendelse som mellemprodukter ved fremstilling af terapeutisk værdifulde 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider og fremgangsmåde til fremstilling deraf. - Google Patents

4,6-0-Alkyliden-β-D-glucopyranoser til anvendelse som mellemprodukter ved fremstilling af terapeutisk værdifulde 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider og fremgangsmåde til fremstilling deraf.

Info

Publication number
DK128563B
DK128563B DK266771AA DK266771A DK128563B DK 128563 B DK128563 B DK 128563B DK 266771A A DK266771A A DK 266771AA DK 266771 A DK266771 A DK 266771A DK 128563 B DK128563 B DK 128563B
Authority
DK
Denmark
Prior art keywords
alkylidene
preparation
demethylpipodophyllotoxin
glucopyranoses
glucosides
Prior art date
Application number
DK266771AA
Other languages
English (en)
Inventor
M Kuhn
Juslen C Keller
J Renz
Wartburg A Von
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK128563B publication Critical patent/DK128563B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK266771AA 1968-02-27 1971-06-01 4,6-0-Alkyliden-β-D-glucopyranoser til anvendelse som mellemprodukter ved fremstilling af terapeutisk værdifulde 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider og fremgangsmåde til fremstilling deraf. DK128563B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH284568A CH514578A (de) 1968-02-27 1968-02-27 Verfahren zur Herstellung von Glucosiden

Publications (1)

Publication Number Publication Date
DK128563B true DK128563B (da) 1974-05-27

Family

ID=4242875

Family Applications (2)

Application Number Title Priority Date Filing Date
DK64169AA DK123715B (da) 1968-02-27 1969-02-06 Fremgangsmåde til fremstilling af 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider.
DK266771AA DK128563B (da) 1968-02-27 1971-06-01 4,6-0-Alkyliden-β-D-glucopyranoser til anvendelse som mellemprodukter ved fremstilling af terapeutisk værdifulde 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider og fremgangsmåde til fremstilling deraf.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK64169AA DK123715B (da) 1968-02-27 1969-02-06 Fremgangsmåde til fremstilling af 4'-demethylepipodophyllotoxin-β-D-alkylidenglucosider.

Country Status (9)

Country Link
AT (2) AT303270B (da)
BR (1) BR6906655D0 (da)
CA (1) CA956939A (da)
CH (2) CH514578A (da)
CS (2) CS153033B2 (da)
DK (2) DK123715B (da)
FI (1) FI48924C (da)
NL (1) NL166028C (da)
SU (2) SU406346A3 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS61189230A (ja) * 1985-02-19 1986-08-22 Nippon Kayaku Co Ltd エトポシド製剤
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
CA2748034A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
SG11201807965YA (en) 2016-03-15 2018-10-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Also Published As

Publication number Publication date
CA956939A (en) 1974-10-29
FI48924C (fi) 1975-02-10
CS153032B2 (da) 1974-02-22
CH514578A (de) 1971-10-31
NL166028C (nl) 1981-06-15
AT303270B (de) 1972-11-27
NL166028B (nl) 1981-01-15
DK123715B (da) 1972-07-24
CH518927A (de) 1972-02-15
SU406346A3 (da) 1973-11-05
CS153033B2 (da) 1974-02-22
AT319971B (de) 1975-01-27
NL6901619A (da) 1969-08-29
SU447886A3 (ru) 1974-10-25
BR6906655D0 (pt) 1973-01-09
FI48924B (da) 1974-10-31

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