DK1280799T3 - Orthosubstituerede anthranilsyreamider og anvendelse heraf som lægemidler - Google Patents
Orthosubstituerede anthranilsyreamider og anvendelse heraf som lægemidlerInfo
- Publication number
- DK1280799T3 DK1280799T3 DK01940416T DK01940416T DK1280799T3 DK 1280799 T3 DK1280799 T3 DK 1280799T3 DK 01940416 T DK01940416 T DK 01940416T DK 01940416 T DK01940416 T DK 01940416T DK 1280799 T3 DK1280799 T3 DK 1280799T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid amides
- anthranilic acid
- orthosubstituted
- drugs
- ortho
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10023486A DE10023486C1 (de) | 2000-05-09 | 2000-05-09 | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
PCT/EP2001/005214 WO2001085719A1 (de) | 2000-05-09 | 2001-05-08 | Ortho substituierte anthranilsäureamide und deren verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1280799T3 true DK1280799T3 (da) | 2004-05-10 |
Family
ID=7641923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01940416T DK1280799T3 (da) | 2000-05-09 | 2001-05-08 | Orthosubstituerede anthranilsyreamider og anvendelse heraf som lægemidler |
Country Status (31)
Country | Link |
---|---|
US (2) | US7081468B2 (da) |
EP (1) | EP1280799B1 (da) |
JP (1) | JP2003532725A (da) |
KR (1) | KR20020094024A (da) |
CN (1) | CN1237062C (da) |
AT (1) | ATE258174T1 (da) |
AU (2) | AU7400101A (da) |
BG (1) | BG107261A (da) |
BR (1) | BR0110621A (da) |
CA (1) | CA2407852A1 (da) |
CZ (1) | CZ20023677A3 (da) |
DE (2) | DE10023486C1 (da) |
DK (1) | DK1280799T3 (da) |
EE (1) | EE04938B1 (da) |
ES (1) | ES2214424T3 (da) |
HK (1) | HK1056728A1 (da) |
HR (1) | HRP20020977B1 (da) |
HU (1) | HUP0301954A2 (da) |
IL (2) | IL152578A0 (da) |
MX (1) | MXPA02010915A (da) |
NO (1) | NO323541B1 (da) |
NZ (1) | NZ521700A (da) |
PL (1) | PL358204A1 (da) |
PT (1) | PT1280799E (da) |
RU (1) | RU2264399C2 (da) |
SK (1) | SK15882002A3 (da) |
TR (1) | TR200400912T4 (da) |
UA (1) | UA73187C2 (da) |
WO (1) | WO2001085719A1 (da) |
YU (1) | YU82702A (da) |
ZA (1) | ZA200209896B (da) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10023484A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
DE10023486C1 (de) * | 2000-05-09 | 2002-03-14 | Schering Ag | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7105682B2 (en) * | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
US7307088B2 (en) * | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
US7615565B2 (en) | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
CN1671666A (zh) * | 2002-07-31 | 2005-09-21 | 舍林股份公司 | Vegfr-2和vegfr-3抑制性的邻氨基苯甲酰胺吡啶化合物 |
EP1628661A2 (en) * | 2003-06-05 | 2006-03-01 | Vertex Pharmaceuticals Incorporated | Modulators of vr1 receptor |
DE10327719A1 (de) * | 2003-06-13 | 2005-01-20 | Schering Ag | VEGFR-2 und VEGFR-3 Inhibitorische Anthranylamidpyridone |
US7202260B2 (en) * | 2003-06-13 | 2007-04-10 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones |
EP1668013B1 (en) | 2003-09-23 | 2012-02-22 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
DE102004009238A1 (de) * | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | Arylamid-Derivate |
DE102004011720B4 (de) * | 2004-03-10 | 2008-04-03 | Bayer Schering Pharma Aktiengesellschaft | Radiohalogenierte Benzamidderivate und deren Verwendung in der Tumordiagnostik und Tumortherapie |
US7427390B2 (en) * | 2004-03-10 | 2008-09-23 | Schering Ag | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy |
EP1657241A1 (en) | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US7906533B2 (en) | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
JP5169220B2 (ja) * | 2005-11-30 | 2013-03-27 | アステラス製薬株式会社 | 2−アミノベンズアミド誘導体 |
KR102392684B1 (ko) | 2014-01-13 | 2022-04-29 | 오리진 디스커버리 테크놀로지스 리미티드 | Irak4 억제제로서의 바이시클릭 헤테로시클릴 유도체 |
KR20170016500A (ko) * | 2014-06-20 | 2017-02-13 | 오리진 디스커버리 테크놀로지스 리미티드 | Irak4 저해제로서의 치환된 인다졸 화합물 |
IL293783B2 (en) | 2017-03-31 | 2024-01-01 | Aurigene Oncology Ltd | Compounds and preparations for the treatment of hematological disorders |
PL3704108T3 (pl) | 2017-10-31 | 2024-07-22 | Curis, Inc. | Inhibitor irak4 w połączeniu z inhibitorem bcl-2 do stosowania w leczeniu nowotworu złośliwego |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409668A (en) * | 1964-11-07 | 1968-11-05 | Palazzo Giuseppe | Substituted anthranilamides and process for the preparation thereof |
FR2689508B1 (fr) * | 1992-04-01 | 1994-06-17 | Fournier Ind & Sante | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
UA71587C2 (uk) * | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
DE10023486C1 (de) * | 2000-05-09 | 2002-03-14 | Schering Ag | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
DE10023484A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
MXPA03010099A (es) * | 2001-05-08 | 2004-03-10 | Schering Ag | Amidas de antranilamida-piridina selectivas como inhibidores de vegfr-2 y vegfr-3. |
US20040039019A1 (en) * | 2002-06-19 | 2004-02-26 | Schering Ag | Selected anthranilaminde pyridinamides and their use as pharmaceutical agents |
US7517894B2 (en) * | 2002-07-31 | 2009-04-14 | Bayer Schering Pharma Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
US7615565B2 (en) * | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
US7202260B2 (en) * | 2003-06-13 | 2007-04-10 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones |
MX2007000816A (es) * | 2004-07-19 | 2007-06-05 | Thia Medica As | Composicion que comprende material de proteina y compuestos que comprenden entidades de acido graso no oxidable. |
EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US7906533B2 (en) * | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
EP1657241A1 (en) * | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US20060266770A1 (en) * | 2005-05-26 | 2006-11-30 | Fitzgerald Robert M | Portable dispensers comprising a mobile dispenser and mobile storage cartridge |
-
2000
- 2000-05-09 DE DE10023486A patent/DE10023486C1/de not_active Expired - Fee Related
-
2001
- 2001-05-08 DE DE50101364T patent/DE50101364D1/de not_active Expired - Fee Related
- 2001-05-08 EE EEP200200625A patent/EE04938B1/xx not_active IP Right Cessation
- 2001-05-08 KR KR1020027014966A patent/KR20020094024A/ko active IP Right Grant
- 2001-05-08 PL PL01358204A patent/PL358204A1/xx unknown
- 2001-05-08 TR TR2004/00912T patent/TR200400912T4/xx unknown
- 2001-05-08 HU HU0301954A patent/HUP0301954A2/hu unknown
- 2001-05-08 AU AU7400101A patent/AU7400101A/xx active Pending
- 2001-05-08 JP JP2001582320A patent/JP2003532725A/ja active Pending
- 2001-05-08 AU AU2001274001A patent/AU2001274001B2/en not_active Ceased
- 2001-05-08 DK DK01940416T patent/DK1280799T3/da active
- 2001-05-08 CN CNB018091369A patent/CN1237062C/zh not_active Expired - Fee Related
- 2001-05-08 CA CA002407852A patent/CA2407852A1/en not_active Abandoned
- 2001-05-08 RU RU2002131887/04A patent/RU2264399C2/ru not_active IP Right Cessation
- 2001-05-08 AT AT01940416T patent/ATE258174T1/de not_active IP Right Cessation
- 2001-05-08 YU YU82702A patent/YU82702A/sh unknown
- 2001-05-08 PT PT01940416T patent/PT1280799E/pt unknown
- 2001-05-08 CZ CZ20023677A patent/CZ20023677A3/cs unknown
- 2001-05-08 ES ES01940416T patent/ES2214424T3/es not_active Expired - Lifetime
- 2001-05-08 SK SK1588-2002A patent/SK15882002A3/sk unknown
- 2001-05-08 EP EP01940416A patent/EP1280799B1/de not_active Expired - Lifetime
- 2001-05-08 IL IL15257801A patent/IL152578A0/xx unknown
- 2001-05-08 MX MXPA02010915A patent/MXPA02010915A/es active IP Right Grant
- 2001-05-08 WO PCT/EP2001/005214 patent/WO2001085719A1/de active IP Right Grant
- 2001-05-08 BR BR0110621-0A patent/BR0110621A/pt not_active IP Right Cessation
- 2001-05-08 US US10/275,480 patent/US7081468B2/en not_active Expired - Fee Related
- 2001-05-08 NZ NZ521700A patent/NZ521700A/en unknown
- 2001-08-05 UA UA2002129865A patent/UA73187C2/uk unknown
-
2002
- 2002-10-31 IL IL152578A patent/IL152578A/en not_active IP Right Cessation
- 2002-11-08 NO NO20025358A patent/NO323541B1/no unknown
- 2002-11-08 BG BG107261A patent/BG107261A/bg unknown
- 2002-12-05 ZA ZA200209896A patent/ZA200209896B/en unknown
- 2002-12-09 HR HR20020977A patent/HRP20020977B1/xx not_active IP Right Cessation
-
2003
- 2003-12-13 HK HK03109101A patent/HK1056728A1/xx not_active IP Right Cessation
-
2005
- 2005-09-06 US US11/218,423 patent/US20060014747A1/en not_active Abandoned
Also Published As
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