DK1244433T3 - Anvendelse af ikke-humant SHIP2-knockout-pattedyr - Google Patents

Anvendelse af ikke-humant SHIP2-knockout-pattedyr

Info

Publication number
DK1244433T3
DK1244433T3 DK00974190T DK00974190T DK1244433T3 DK 1244433 T3 DK1244433 T3 DK 1244433T3 DK 00974190 T DK00974190 T DK 00974190T DK 00974190 T DK00974190 T DK 00974190T DK 1244433 T3 DK1244433 T3 DK 1244433T3
Authority
DK
Denmark
Prior art keywords
ship2
inhibitor
human
present
knockout mammals
Prior art date
Application number
DK00974190T
Other languages
English (en)
Inventor
Christophe Erneux
Stephane Schurmans
Original Assignee
Euroscreen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroscreen Sa filed Critical Euroscreen Sa
Application granted granted Critical
Publication of DK1244433T3 publication Critical patent/DK1244433T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal (AREA)
DK00974190T 1999-11-03 2000-10-31 Anvendelse af ikke-humant SHIP2-knockout-pattedyr DK1244433T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99870229A EP1097713A1 (en) 1999-11-03 1999-11-03 Inhibitors of the inositol polyphosphate 5-phosphatase ship-2 molecule

Publications (1)

Publication Number Publication Date
DK1244433T3 true DK1244433T3 (da) 2006-07-10

Family

ID=8243920

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00974190T DK1244433T3 (da) 1999-11-03 2000-10-31 Anvendelse af ikke-humant SHIP2-knockout-pattedyr

Country Status (9)

Country Link
US (4) US6703215B2 (da)
EP (2) EP1097713A1 (da)
JP (1) JP2003515532A (da)
AT (1) ATE318511T1 (da)
CA (1) CA2388180C (da)
DE (1) DE60026347T2 (da)
DK (1) DK1244433T3 (da)
ES (1) ES2259293T3 (da)
WO (1) WO2001032186A2 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1097713A1 (en) * 1999-11-03 2001-05-09 Euroscreen S.A. Inhibitors of the inositol polyphosphate 5-phosphatase ship-2 molecule
EP1318841A2 (en) * 2000-09-19 2003-06-18 University Of South Florida Control of nk cell function and survival by modulation of ship activity
US20020165192A1 (en) * 2000-09-19 2002-11-07 Kerr William G. Control of NK cell function and survival by modulation of ship activity
US7691821B2 (en) * 2001-09-19 2010-04-06 University Of South Florida Inhibition of SHIP to enhance stem cell harvest and transplantation
US20070224124A1 (en) * 2002-09-30 2007-09-27 University Of South Florida Novel SH2containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein
US7807646B1 (en) * 2003-11-20 2010-10-05 University Of South Florida SHIP-deficiency to increase megakaryocyte progenitor production
US7763592B1 (en) * 2003-11-20 2010-07-27 University Of South Florida SHIP-deficiency to increase megakaryocyte progenitor production
EP1987837A1 (en) * 2007-05-02 2008-11-05 Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus Pharmaceutical composition for increasing insulin secretion from pancreatic ß-cells
WO2012169571A1 (ja) * 2011-06-09 2012-12-13 国立大学法人 富山大学 新規なｎ－（ピリジン－２－イル）アルカンアミド誘導体およびそれらを有効成分とするｓｈｉｐ２阻害剤
US20170336425A1 (en) * 2016-05-18 2017-11-23 The Cleveland Clinic Foundation Pip2 as a marker for hdl function and cardiovascular disease risk

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023248A (en) * 1984-10-23 1991-06-11 Perstorp Ab Method of treating diabetes with inositol triphosphate
JP2750239B2 (ja) * 1991-08-14 1998-05-13 三共株式会社 アデノホスチンａまたはｂならびにその製法
US6218162B1 (en) * 1995-09-27 2001-04-17 Gerald Krystal SH2-containing inositol-phosphatase
GB9525702D0 (en) * 1995-12-15 1996-02-14 Ciba Geigy Ag Process for activating a kinase
US5885980A (en) * 1996-06-25 1999-03-23 Enrique G. Gutierrez Composition and method for treating diabetes
AU721150B2 (en) * 1996-09-20 2000-06-22 Inologic, Inc. Inositol polyphosphate derivatives and methods of using same
US6025198A (en) * 1999-06-25 2000-02-15 Isis Pharmaceuticals Inc. Antisense modulation of Ship-2 expression
EP1097713A1 (en) * 1999-11-03 2001-05-09 Euroscreen S.A. Inhibitors of the inositol polyphosphate 5-phosphatase ship-2 molecule

Also Published As

Publication number Publication date
EP1097713A1 (en) 2001-05-09
US20020106713A1 (en) 2002-08-08
US6703215B2 (en) 2004-03-09
JP2003515532A (ja) 2003-05-07
US20040209342A1 (en) 2004-10-21
CA2388180A1 (en) 2001-05-10
DE60026347T2 (de) 2006-12-14
ES2259293T3 (es) 2006-10-01
WO2001032186A3 (en) 2002-07-25
US20040203087A1 (en) 2004-10-14
EP1244433A2 (en) 2002-10-02
US7094546B2 (en) 2006-08-22
CA2388180C (en) 2012-01-03
WO2001032186A2 (en) 2001-05-10
US20050183146A1 (en) 2005-08-18
ATE318511T1 (de) 2006-03-15
US6936452B2 (en) 2005-08-30
DE60026347D1 (de) 2006-04-27
EP1244433B1 (en) 2006-03-01

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