DK1198570T3 - Monomert protein af TGF-Beta-familien - Google Patents
Monomert protein af TGF-Beta-familienInfo
- Publication number
- DK1198570T3 DK1198570T3 DK00958383T DK00958383T DK1198570T3 DK 1198570 T3 DK1198570 T3 DK 1198570T3 DK 00958383 T DK00958383 T DK 00958383T DK 00958383 T DK00958383 T DK 00958383T DK 1198570 T3 DK1198570 T3 DK 1198570T3
- Authority
- DK
- Denmark
- Prior art keywords
- proteins
- tgf
- nucleic acids
- monomeric
- monomeric protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000043168 TGF-beta family Human genes 0.000 title 1
- 108091085018 TGF-beta family Proteins 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99115613A EP1074620A1 (fr) | 1999-08-06 | 1999-08-06 | Protéine monomère de la famille TGF-beta |
| EP00958383A EP1198570B1 (fr) | 1999-08-06 | 2000-08-04 | Proteine monomere de la famille des tgf-beta |
| PCT/EP2000/007600 WO2001011041A1 (fr) | 1999-08-06 | 2000-08-04 | PROTEINE MONOMERE DE LA FAMILLE DES TGF-$g(b) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1198570T3 true DK1198570T3 (da) | 2005-10-31 |
Family
ID=8238746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00958383T DK1198570T3 (da) | 1999-08-06 | 2000-08-04 | Monomert protein af TGF-Beta-familien |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6972321B1 (fr) |
| EP (3) | EP1074620A1 (fr) |
| JP (1) | JP2003506086A (fr) |
| AT (1) | ATE299937T1 (fr) |
| AU (1) | AU782481B2 (fr) |
| CA (1) | CA2381219C (fr) |
| DE (1) | DE60021388T2 (fr) |
| DK (1) | DK1198570T3 (fr) |
| ES (1) | ES2242630T3 (fr) |
| NZ (1) | NZ517125A (fr) |
| WO (1) | WO2001011041A1 (fr) |
| ZA (1) | ZA200201032B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7811793B2 (en) * | 1996-12-25 | 2010-10-12 | Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Process for preparing purified active monomer of bone-derived factor |
| JP4920851B2 (ja) * | 2000-04-20 | 2012-04-18 | セイント ヴィンセンツ ホスピタル シドニー リミテッド | マクロファージ抑制サイトカイン−１（ｍｉｃ−１）が関連する検査方法 |
| WO2002076494A2 (fr) | 2001-03-23 | 2002-10-03 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | UTILISATION DE CYTOKINES DE LA SUPERFAMILLE TGF-β POUR LE TRAITEMENT ET LE DIAGNOSTIC DE TROUBLES DE LA PEAU |
| FI116827B (fi) | 2001-08-24 | 2006-03-15 | Univ Zuerich | Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö |
| EG23432A (fr) | 2001-12-17 | 2005-07-25 | New Zealand Dairy Board | |
| CA2491513A1 (fr) * | 2002-07-09 | 2004-01-15 | Stryker Corporation | Compositions et methodes de permettant de stimuler la croissance ligamentaire et de reparer les ligaments |
| EP1462126A1 (fr) * | 2003-03-28 | 2004-09-29 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Matériaux ostéoinductifs améliorés |
| GB0514262D0 (en) * | 2005-07-12 | 2005-08-17 | Renovo Ltd | Promotion of epithelial regeneration |
| ES2382464T3 (es) | 2005-11-18 | 2012-06-08 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Mutantes de factor del crecimiento de actividad elevada |
| GB0604966D0 (en) * | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
| GB0604938D0 (en) * | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
| EP2027152B1 (fr) | 2006-06-13 | 2011-11-16 | Helix Biomedix Inc. | Fragments peptidiques destinés à induire la synthèse de protéines matricielles extracellulaires |
| EP1880731A1 (fr) * | 2006-07-18 | 2008-01-23 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Facteur de differenciation et de croissance humain |
| GB0617816D0 (en) * | 2006-09-11 | 2006-10-18 | Renovo Ltd | Nucleic acids and methods of protein expression |
| US20100047299A1 (en) * | 2007-01-25 | 2010-02-25 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Use of gdf-5 for the improvement or maintenance of dermal appearance |
| JP2011522565A (ja) * | 2008-06-09 | 2011-08-04 | ワイス・エルエルシー | 新規ｂｍｐ−１２関連タンパク質およびその製造方法 |
| WO2012013790A1 (fr) | 2010-07-30 | 2012-02-02 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dispositifs d'administration de médicaments et formulations de facteur de croissance pour accélérer la cicatrisation de plaies |
| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| EP2537538A1 (fr) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Pansement biorésorbable |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| EP2602264A1 (fr) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Mutant de GDF-5 pour induire la formation de cartilage |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| CN114786707A (zh) | 2019-12-18 | 2022-07-22 | 默克专利股份公司 | Gdf-5突变体用于治疗疼痛和软骨破坏的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19525416A1 (de) * | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
| CA2153654A1 (fr) * | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Facteur 5 de differentiation de croissance |
| US5420243A (en) * | 1993-01-26 | 1995-05-30 | Celtrix Pharmaceuticals, Inc. | Biologically active TGF-β2 peptides |
| IL110589A0 (en) * | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| DE69434651T2 (de) * | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| IL114397A0 (en) * | 1994-07-01 | 1995-10-31 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF-beta-family |
| JPH09295945A (ja) * | 1996-04-30 | 1997-11-18 | Hoechst Yakuhin Kogyo Kk | 成熟型骨誘導因子の製造方法 |
| JPH11335398A (ja) * | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
-
1999
- 1999-08-06 EP EP99115613A patent/EP1074620A1/fr not_active Withdrawn
-
2000
- 2000-08-04 ES ES00958383T patent/ES2242630T3/es not_active Expired - Lifetime
- 2000-08-04 DE DE60021388T patent/DE60021388T2/de not_active Expired - Lifetime
- 2000-08-04 EP EP00958383A patent/EP1198570B1/fr not_active Expired - Lifetime
- 2000-08-04 US US10/048,458 patent/US6972321B1/en not_active Expired - Lifetime
- 2000-08-04 CA CA002381219A patent/CA2381219C/fr not_active Expired - Fee Related
- 2000-08-04 AT AT00958383T patent/ATE299937T1/de active
- 2000-08-04 NZ NZ517125A patent/NZ517125A/en not_active IP Right Cessation
- 2000-08-04 EP EP05013166A patent/EP1574578A1/fr not_active Withdrawn
- 2000-08-04 JP JP2001515827A patent/JP2003506086A/ja active Pending
- 2000-08-04 DK DK00958383T patent/DK1198570T3/da active
- 2000-08-04 WO PCT/EP2000/007600 patent/WO2001011041A1/fr active IP Right Grant
- 2000-08-04 AU AU69927/00A patent/AU782481B2/en not_active Ceased
-
2002
- 2002-02-06 ZA ZA200201032A patent/ZA200201032B/xx unknown
-
2005
- 2005-07-28 US US11/191,072 patent/US7569227B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ517125A (en) | 2003-08-29 |
| AU782481B2 (en) | 2005-08-04 |
| ZA200201032B (en) | 2002-12-24 |
| CA2381219A1 (fr) | 2001-02-15 |
| ES2242630T3 (es) | 2005-11-16 |
| EP1074620A1 (fr) | 2001-02-07 |
| WO2001011041A1 (fr) | 2001-02-15 |
| DE60021388D1 (de) | 2005-08-25 |
| US20050282255A1 (en) | 2005-12-22 |
| US6972321B1 (en) | 2005-12-06 |
| DE60021388T2 (de) | 2006-01-05 |
| CA2381219C (fr) | 2008-11-18 |
| AU6992700A (en) | 2001-03-05 |
| ATE299937T1 (de) | 2005-08-15 |
| US7569227B2 (en) | 2009-08-04 |
| EP1574578A1 (fr) | 2005-09-14 |
| EP1198570B1 (fr) | 2005-07-20 |
| EP1198570A1 (fr) | 2002-04-24 |
| JP2003506086A (ja) | 2003-02-18 |
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