DK1178830T3 - Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser - Google Patents

Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser

Info

Publication number
DK1178830T3
DK1178830T3 DK00926343T DK00926343T DK1178830T3 DK 1178830 T3 DK1178830 T3 DK 1178830T3 DK 00926343 T DK00926343 T DK 00926343T DK 00926343 T DK00926343 T DK 00926343T DK 1178830 T3 DK1178830 T3 DK 1178830T3
Authority
DK
Denmark
Prior art keywords
therapy
imaging
detection
dye
useful
Prior art date
Application number
DK00926343T
Other languages
Danish (da)
English (en)
Inventor
Samuel Achilefu
Richard Bradley Dorshow
Joseph Edward Bugaj
Raghavan Rajagopalan
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DK1178830T3 publication Critical patent/DK1178830T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00926343T 1999-05-20 2000-04-26 Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser DK1178830T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13506099P 1999-05-20 1999-05-20
US09/325,769 US6217848B1 (en) 1999-05-20 1999-06-04 Cyanine and indocyanine dye bioconjugates for biomedical applications
PCT/US2000/011060 WO2000071162A2 (fr) 1999-05-20 2000-04-26 Nouveaux bioconjugues cyanine et indocyanine pour application medicale

Publications (1)

Publication Number Publication Date
DK1178830T3 true DK1178830T3 (da) 2009-10-12

Family

ID=26832945

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00926343T DK1178830T3 (da) 1999-05-20 2000-04-26 Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser

Country Status (11)

Country Link
US (1) US6217848B1 (fr)
EP (2) EP1178830B1 (fr)
JP (1) JP2003500367A (fr)
AT (1) ATE435662T1 (fr)
AU (1) AU4488800A (fr)
CA (1) CA2373475C (fr)
DE (1) DE60042522D1 (fr)
DK (1) DK1178830T3 (fr)
ES (1) ES2329542T3 (fr)
PT (1) PT1178830E (fr)
WO (1) WO2000071162A2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) * 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US20050182434A1 (en) * 2000-08-11 2005-08-18 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US20030017164A1 (en) * 2001-07-03 2003-01-23 Mallinckrodt Inc. Dye-azide compounds for dual phototherapy
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US7351807B2 (en) * 2000-01-18 2008-04-01 Mallinckrodt Inc. Cyanine-sulfenates for dual phototherapy
US7230088B2 (en) * 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
US6658143B2 (en) * 2002-04-29 2003-12-02 Amersham Biosciences Corp. Ray-based image analysis for biological specimens
DE10339784B4 (de) 2002-08-28 2021-09-16 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10302787A1 (de) * 2003-01-24 2004-08-12 Schering Ag Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
EP1613351A1 (fr) * 2003-03-10 2006-01-11 MPA Technologies, Inc. Agents cibles pour photodiagnostic et therapie photodynamique
WO2005000218A2 (fr) * 2003-05-31 2005-01-06 Washington University Bioconjugues macrocycliques a base de cyanine et d'indocyanine pour applications biomedicales ameliorees
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
NO20035681D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av lungekreft
NO20035682D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av ösofagkreft og Barretts ösofag
DE102004022628A1 (de) * 2004-05-07 2005-12-15 Sensient Imaging Technologies Gmbh FRET-Bioassay
US7585492B2 (en) * 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
US20050272967A1 (en) * 2004-05-18 2005-12-08 Siemens Aktiengesellschaft Biomolecular contrast agents with multiple signal variance for therapy planning and control in radiation therapy with proton or ion beams
US20050259779A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy optimization in radiation therapy with proton or ion beams
US20060239916A1 (en) * 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
GB0714202D0 (en) * 2007-07-20 2007-08-29 Ge Healthcare Bio Sciences Ab Isoelectric point markers
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
EP2100621A1 (fr) 2008-03-10 2009-09-16 mivenion GmbH Conjugués de dendrimère de polyol de polyéther dotés de molécules effectrices pour le ciblage biologique
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
ES2671710T3 (es) 2008-05-02 2018-06-08 Novadaq Technologies ULC Métodos para la producción y uso de eritrocitos cargados con sustancias para la observación y el tratamiento de la hemodinámica microvascular
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
EP2471556A4 (fr) 2009-10-05 2015-06-03 Canon Kk Produit de contraste pour imagerie photoacoustique et procédé d'imagerie photoacoustique mettant en oeuvre celui-ci
WO2012054784A1 (fr) 2010-10-20 2012-04-26 Li-Cor, Inc. Imagerie de fluorescence à colorants à base de cyanine substituée
EP2686385B1 (fr) 2011-03-15 2019-01-16 Ramot at Tel Aviv University, Ltd. Composés fluorogéniques activables et leurs utilisations en tant que sondes infrarouge proche
CA2851344C (fr) * 2011-09-05 2017-10-03 Hiroshi Maeda Sonde moleculaire fluorescente de type polymere
EP2806781B1 (fr) 2012-01-23 2018-03-21 Washington University Systèmes et procédés d'imagerie
EP2863801B8 (fr) 2012-06-21 2024-06-12 Stryker Corporation Quantification et analyse d'angiographie et de perfusion
CN104704366B (zh) * 2012-10-24 2018-06-19 贝克顿·迪金森公司 异羟肟酸取代的氮杂吲哚啉-花菁染料和它的生物共轭物
KR101440109B1 (ko) 2013-01-29 2014-09-12 부경대학교 산학협력단 위장관암의 림프절 전이 검출용 광음향 단층촬영 시스템
KR102068776B1 (ko) 2014-09-29 2020-01-21 노바다크 테크놀러지즈 유엘씨 자가형광이 존재하는 생물학적 물질에서 타겟 형광체의 이미징
US10631746B2 (en) 2014-10-09 2020-04-28 Novadaq Technologies ULC Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
WO2016179350A1 (fr) 2015-05-06 2016-11-10 Washington University Composés à motifs de ciblage rd et leurs procédés d'utilisation
EP4242743A3 (fr) 2017-02-10 2023-10-18 Stryker European Operations Limited Systèmes et procédés d'imagerie à fluorescence portative à champ ouvert
WO2021119423A1 (fr) 2019-12-13 2021-06-17 Washington University Colorants fluorescents dans l'infrarouge proche, formulations et procédés associés
WO2023227601A1 (fr) 2022-05-23 2023-11-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Conjugués de colorant heptaméthine fluorescents dans le proche infrarouge ayant des propriétés de blanchiment favorables

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5745457A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Microimmunological measuring method
JP3147992B2 (ja) * 1992-05-29 2001-03-19 イビデン株式会社 免疫測定用標識試薬
JP3354975B2 (ja) * 1992-10-06 2002-12-09 イビデン株式会社 蛍光標識試薬および蛍光免疫測定法
US5453505A (en) 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5962424A (en) * 1995-02-21 1999-10-05 Arch Development Corporation Methods and compositions for targeting selectins
DE19602295C2 (de) * 1996-01-23 2003-08-14 Deutsches Krebsforsch Verwendung eines Konjugats aus einer zur Fluoreszenz-fähigen Verbindung, Cyanurchlorid oder einem Derivat davon als Linker und einem Protein
WO1997033620A2 (fr) * 1996-03-15 1997-09-18 Pulsion Verw. Gmbh & Co. Medical Systems Kg Compose pour traiter des tumeurs
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
WO1998048845A1 (fr) 1997-04-29 1998-11-05 Nycomed Imaging As Procede de delimitation de tissus
WO1998048846A1 (fr) 1997-04-29 1998-11-05 Nycomed Imaging As Agents de contraste utilises dans des techniques d'imagerie basees sur la lumiere
AU766290B2 (en) * 1998-04-03 2003-10-16 Mallinckrodt, Inc. Non-covalent bioconjugates useful for diagnosis and therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
CA2358662A1 (fr) * 1999-01-15 2000-07-20 James Chen Compositions et procedes destines au traitement de troubles metaboliques osseux et de metastases osseuses
WO2000041726A2 (fr) * 1999-01-15 2000-07-20 Light Sciences Corporation Therapie vasculaire non invasive

Also Published As

Publication number Publication date
EP1178830B1 (fr) 2009-07-08
ATE435662T1 (de) 2009-07-15
AU4488800A (en) 2000-12-12
US6217848B1 (en) 2001-04-17
EP1178830A2 (fr) 2002-02-13
CA2373475C (fr) 2012-10-23
WO2000071162A2 (fr) 2000-11-30
PT1178830E (pt) 2009-09-02
EP2058007A2 (fr) 2009-05-13
ES2329542T3 (es) 2009-11-27
WO2000071162A3 (fr) 2001-07-05
EP2058007A3 (fr) 2009-05-27
CA2373475A1 (fr) 2000-11-30
DE60042522D1 (de) 2009-08-20
JP2003500367A (ja) 2003-01-07

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