DK116205B - Analogifremgangsmåde til fremstilling af 17α-alkanoyloxy-9α-halogen-16β-methyl-11β,21-dihydroxy-Δ<1,4>-pregnadien-3,20-dioner. - Google Patents

Analogifremgangsmåde til fremstilling af 17α-alkanoyloxy-9α-halogen-16β-methyl-11β,21-dihydroxy-Δ<1,4>-pregnadien-3,20-dioner.

Info

Publication number
DK116205B
DK116205B DK291064AA DK291064A DK116205B DK 116205 B DK116205 B DK 116205B DK 291064A A DK291064A A DK 291064AA DK 291064 A DK291064 A DK 291064A DK 116205 B DK116205 B DK 116205B
Authority
DK
Denmark
Prior art keywords
pregnadiene
diones
alkanoyloxy
dihydroxy
halogen
Prior art date
Application number
DK291064AA
Other languages
English (en)
Inventor
N Weir
J Elks
P May
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of DK116205B publication Critical patent/DK116205B/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Combinations Of Kitchen Furniture (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Insulated Conductors (AREA)
  • Medicinal Preparation (AREA)
DK291064AA 1963-06-11 1964-06-10 Analogifremgangsmåde til fremstilling af 17α-alkanoyloxy-9α-halogen-16β-methyl-11β,21-dihydroxy-Δ<1,4>-pregnadien-3,20-dioner. DK116205B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB23223/63A GB1047518A (en) 1963-06-11 1963-06-11 17ª‡-monoesters of 11,17,21-trihydroxy steroid compounds
GB362364 1964-01-28

Publications (1)

Publication Number Publication Date
DK116205B true DK116205B (da) 1969-12-22

Family

ID=26238483

Family Applications (2)

Application Number Title Priority Date Filing Date
DK291064AA DK116205B (da) 1963-06-11 1964-06-10 Analogifremgangsmåde til fremstilling af 17α-alkanoyloxy-9α-halogen-16β-methyl-11β,21-dihydroxy-Δ<1,4>-pregnadien-3,20-dioner.
DK291164AA DK116128B (da) 1963-06-11 1964-06-10 Fremgangsmåde til fremstilling af terapeutisk virksomme 17α-(alkanoyloxy eller cycloalkanoyloxy)-21-(alkanoyloxy eller cycloalkanoyloxy)-16β-methyl-9α-halogen-11β-hydroxy-Δ<1,4>-pregnadien-3,20-dioner.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK291164AA DK116128B (da) 1963-06-11 1964-06-10 Fremgangsmåde til fremstilling af terapeutisk virksomme 17α-(alkanoyloxy eller cycloalkanoyloxy)-21-(alkanoyloxy eller cycloalkanoyloxy)-16β-methyl-9α-halogen-11β-hydroxy-Δ<1,4>-pregnadien-3,20-dioner.

Country Status (14)

Country Link
US (1) US3312590A (da)
BE (2) BE649170A (da)
BR (2) BR6459936D0 (da)
CH (2) CH450410A (da)
CY (1) CY544A (da)
DE (2) DE1443958B1 (da)
DK (2) DK116205B (da)
ES (2) ES300814A1 (da)
FR (1) FR4548M (da)
GB (1) GB1047518A (da)
MY (1) MY7000131A (da)
NL (2) NL142157B (da)
NO (2) NO125532B (da)
SE (2) SE320066B (da)

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US4346086A (en) * 1981-06-09 1982-08-24 Beiersdorf Aktiengesellschaft Corticosteroid-containing cream
IL66432A0 (en) * 1981-08-04 1982-12-31 Plurichemie Anstalt Process for the preparation of steroidal esters
DE3133081A1 (de) * 1981-08-18 1983-03-10 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 6(alpha)-methylprednisolon-derivate, ihre herstellung und verwendung
FR2515041A1 (fr) * 1981-10-26 1983-04-29 Besins Jean Medicament a base de progesterone pour le traitement des affections mammaires
EP0095894A3 (en) * 1982-05-31 1985-01-02 Ohta Seiyaku Kabushiki Kaisha. 6 alpha-methylprednisolone derivatives
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3243482A1 (de) * 1982-11-22 1984-05-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6(alpha)-methylkortikoide, ihre herstellung und verwendung
US4482539A (en) * 1983-05-13 1984-11-13 Schering Corporation Betamethasone dipropionate cream
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DE3400188A1 (de) * 1984-01-02 1985-07-11 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 6(alpha),16(alpha)-dimethylkortikoide
PT78973A (en) * 1984-07-25 1984-08-01 Joao Emerico Villax New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
UA26230A (uk) * 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
HU213221B (en) 1990-03-02 1997-03-28 Glaxo Group Ltd Inhalation device and medicine packet for device
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
DZ3468A1 (fr) * 2000-08-05 2002-02-14 Glaxo Group Ltd 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyle) oxy!-11.beta.-hydroxy-16.alpha.-methyle-3-oxo-androst-1,4,-diene-17-acide carbothioique s-fluoromethyle ester utilise comme agent anti inflammatoire
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
CN1302007C (zh) 2001-04-30 2007-02-28 葛兰素集团有限公司 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物
ATE399174T1 (de) * 2001-06-12 2008-07-15 Glaxo Group Ltd Neue anti inflammatorische 17.alpha.- heterozyklische ester von 17.beta.-carbothioat androstan derivativen
AU2002356759A1 (en) * 2001-12-01 2003-06-17 Glaxo Group Limited 17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
RU2387646C2 (ru) * 2003-08-29 2010-04-27 Рэнбакси Лабораториз Лимитед Ингибиторы фосфодиэстеразы типа-iv
EP1694655A2 (en) * 2003-11-26 2006-08-30 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
US20080009535A1 (en) * 2004-08-30 2008-01-10 Sarala Balachandran Inhibitors of phosphodiesterase type-IV
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
JP2009512676A (ja) 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
BRPI0617673C1 (pt) * 2005-10-19 2012-05-22 Ranbaxy Lab Ltd composições de inibidores de fosfodiesterase do tipo iv
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
MX2009003100A (es) * 2006-09-22 2009-05-11 Ranbaxy Lab Ltd Inhibidores de fosfodiesterasa tipo iv.
WO2008035316A2 (en) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
US20080207659A1 (en) * 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
US20110130403A1 (en) * 2007-03-14 2011-06-02 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
JP5671236B2 (ja) 2007-03-14 2015-02-18 ランバクシー ラボラトリーズ リミテッド ホスホジエステラーゼ阻害剤としてのピラゾロ（３，４−ｂ）ピリジン誘導体
WO2009045539A2 (en) 2007-10-05 2009-04-09 Nektar Therapeutics Al, Corporation Oligomer-corticosteroid conjugates
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CN112358522B (zh) * 2020-05-18 2021-11-16 河南利华制药有限公司 一种倍他米松二丙酸酯的精制方法及倍他米松二丙酸酯
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法
CN116023425B (zh) * 2023-03-28 2023-06-20 南京师范大学 曲安西龙衍生物及其医药用途

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US3147249A (en) * 1961-06-13 1964-09-01 Vismara Francesco Spa 17alpha, 21-substituted methylenedioxy steroids and methods therefor
DE1195748B (de) * 1961-06-24 1965-07-01 Vismara Francesco Spa Verfahren zur Herstellung von 1'-substituierten 17alpha, 21-(1'-Alkoxy)-methylendioxysterioden

Also Published As

Publication number Publication date
NL6406615A (da) 1964-12-14
DK116128B (da) 1969-12-15
NL6406614A (da) 1964-12-14
NL142157B (nl) 1974-05-15
CH450410A (de) 1968-01-31
BR6459936D0 (pt) 1973-08-02
NO125532B (da) 1972-09-25
FR4548M (da) 1966-11-02
MY7000131A (en) 1970-12-31
BE649171A (da) 1964-12-11
DE1443957B1 (de) 1970-01-02
CH457422A (de) 1968-06-15
NL141378B (nl) 1974-03-15
DE1443958B1 (de) 1970-01-02
ES300811A1 (es) 1962-12-16
SE320066B (da) 1970-02-02
SE313562B (da) 1969-08-18
NO125533B (da) 1972-09-25
BR6459937D0 (pt) 1973-08-07
CY544A (en) 1970-07-02
BE649170A (da) 1964-12-11
GB1047518A (en) 1966-11-02
US3312590A (en) 1967-04-04
ES300814A1 (es) 1964-12-01

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