DK1161234T3 - Behandling af pulmonær hypertension ved inhalation af benzindenprostaglandiner - Google Patents

Behandling af pulmonær hypertension ved inhalation af benzindenprostaglandiner

Info

Publication number
DK1161234T3
DK1161234T3 DK00920253T DK00920253T DK1161234T3 DK 1161234 T3 DK1161234 T3 DK 1161234T3 DK 00920253 T DK00920253 T DK 00920253T DK 00920253 T DK00920253 T DK 00920253T DK 1161234 T3 DK1161234 T3 DK 1161234T3
Authority
DK
Denmark
Prior art keywords
inhalation
prostaglandins
pulmonary hypertension
gasoline
treatment
Prior art date
Application number
DK00920253T
Other languages
Danish (da)
English (en)
Inventor
Gilles Cloutier
James Crow
Michael Wade
Richard E Parker
James E Loyd
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22417774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1161234(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Application granted granted Critical
Publication of DK1161234T3 publication Critical patent/DK1161234T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK00920253T 1999-03-18 2000-03-17 Behandling af pulmonær hypertension ved inhalation af benzindenprostaglandiner DK1161234T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12499999P 1999-03-18 1999-03-18
PCT/US2000/040040 WO2000054758A2 (en) 1999-03-18 2000-03-17 Method for delivering benzidine prostaglandins by inhalation

Publications (1)

Publication Number Publication Date
DK1161234T3 true DK1161234T3 (da) 2003-11-24

Family

ID=22417774

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00920253T DK1161234T3 (da) 1999-03-18 2000-03-17 Behandling af pulmonær hypertension ved inhalation af benzindenprostaglandiner

Country Status (13)

Country Link
US (2) US6521212B1 (ja)
EP (1) EP1161234B1 (ja)
JP (2) JP4819224B2 (ja)
KR (1) KR100750384B1 (ja)
CN (1) CN1196479C (ja)
AT (1) ATE245979T1 (ja)
AU (1) AU4082700A (ja)
CA (1) CA2365890C (ja)
DE (1) DE60004181T2 (ja)
DK (1) DK1161234T3 (ja)
ES (1) ES2203449T3 (ja)
PT (1) PT1161234E (ja)
WO (1) WO2000054758A2 (ja)

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US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
DE602004022982D1 (de) * 2003-12-16 2009-10-15 United Therapeutics Corp Verwendung von treprostinil zur verbesserung der nierenfunktion
US8765813B2 (en) * 2003-12-16 2014-07-01 United Therapeutics Corporation Use of treprostinil to treat and prevent ischemic lesions
US20090124697A1 (en) * 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
EP1744739B1 (en) * 2004-04-12 2010-03-31 United Therapeutics Corporation Use of treprostinil to treat neuropathic diabetic foot ulcers
CA2588994A1 (en) * 2004-12-08 2006-06-15 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
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EP2252570B1 (en) 2007-12-17 2017-04-05 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin ®
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ES2611187T3 (es) 2010-03-15 2017-05-05 United Therapeutics Corporation Tratamiento para hipertensión pulmonar
CN103261142B (zh) 2010-06-03 2014-12-10 联合治疗公司 曲前列环素的制备
JP5580491B2 (ja) 2011-03-02 2014-08-27 ユナイテッド セラピューティクス コーポレイション トレプロスチニル製造のための中間体の合成
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
KR20150089087A (ko) * 2012-11-30 2015-08-04 인스메드 인코포레이티드 프로스타사이클린 조성물 및 이를 이용하기 위한 방법
CN105164098A (zh) 2013-03-14 2015-12-16 联合治疗公司 曲前列环素的固体形式
EP2970081A4 (en) 2013-03-15 2016-10-12 United Therapeutics Corp SALTS OF TREPROSTINIL
ES2676447T3 (es) 2013-03-25 2018-07-19 United Therapeutics Corporation Procedimiento de fabricación de compuestos de prostaciclina con tiol de unión y formas pegiladas
MX2020004912A (es) 2013-10-25 2021-05-21 Insmed Inc Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar.
CN106573066A (zh) 2014-06-13 2017-04-19 联合治疗学有限公司 曲前列环素制剂
EP3209415B1 (en) 2014-10-20 2020-02-19 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives
CA2967385C (en) 2014-11-18 2023-05-16 Insmed Incorporated Methods of manufacturing treprostinil and treprostinil derivative prodrugs
CA2967899C (en) 2014-12-03 2023-09-19 Steadymed Ltd Preservative-free treprostinil formulations and methods and devices for use with same
RU2593016C2 (ru) * 2014-12-15 2016-07-27 Федеральное государственное бюджетное учреждение науки Институт теоретической и прикладной механики им. С.А. Христиановича Сибирского отделения Российской академии наук (ИТПМ СО РАН) Способ лечения артериальной гипертензии путем ингаляционного введения аэрозоля гипотензивного препарата
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CN116889649A (zh) 2018-10-05 2023-10-17 药物治疗股份有限公司 生物制品在制造用于人接受者的移植物中的应用
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
MX2021013329A (es) 2019-04-29 2022-03-17 Insmed Inc Composiciones de polvo seco de los profarmacos de treprostinil y métodos de uso de las mismas.
EP3750528A1 (en) 2019-06-11 2020-12-16 Nexien Biopharma, Inc. Compositions for treating dystrophies and myotonia
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US11339110B2 (en) 2019-12-19 2022-05-24 Chirogate International Inc. Efficient crystallization process for preparing ultrapure Treprostinil and crystal prepared therefrom
IL296567A (en) 2020-04-17 2022-11-01 United Therapeutics Corp Terfostinil for use in the treatment of interstitial lung disease
CA3180230A1 (en) 2020-06-09 2021-12-16 Hitesh Batra Fumaryl diketopiperidine prodrugs of treprostinil
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Also Published As

Publication number Publication date
US6521212B1 (en) 2003-02-18
US20030053958A1 (en) 2003-03-20
CN1379665A (zh) 2002-11-13
WO2000054758A2 (en) 2000-09-21
EP1161234B1 (en) 2003-07-30
ATE245979T1 (de) 2003-08-15
JP4819224B2 (ja) 2011-11-24
WO2000054758A3 (en) 2001-02-08
JP2002539154A (ja) 2002-11-19
US6756033B2 (en) 2004-06-29
KR20010108352A (ko) 2001-12-07
JP2011201907A (ja) 2011-10-13
CA2365890A1 (en) 2000-09-21
CN1196479C (zh) 2005-04-13
DE60004181D1 (de) 2003-09-04
CA2365890C (en) 2010-09-21
AU4082700A (en) 2000-10-04
PT1161234E (pt) 2003-12-31
EP1161234A2 (en) 2001-12-12
DE60004181T2 (de) 2004-04-15
KR100750384B1 (ko) 2007-08-17
ES2203449T3 (es) 2004-04-16

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