DK115473B - Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf. - Google Patents

Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.

Info

Publication number
DK115473B
DK115473B DK63068AA DK63068A DK115473B DK 115473 B DK115473 B DK 115473B DK 63068A A DK63068A A DK 63068AA DK 63068 A DK63068 A DK 63068A DK 115473 B DK115473 B DK 115473B
Authority
DK
Denmark
Prior art keywords
benzazepines
tetrahydro
preparation
acid addition
addition salts
Prior art date
Application number
DK63068AA
Other languages
Danish (da)
English (en)
Inventor
K Hoegerle
E Habicht
Original Assignee
Geigy Ag J R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geigy Ag J R filed Critical Geigy Ag J R
Publication of DK115473B publication Critical patent/DK115473B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Drawers Of Furniture (AREA)
DK63068AA 1967-02-17 1968-02-16 Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf. DK115473B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH238667A CH481110A (de) 1967-02-17 1967-02-17 Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
CH1167167A CH488705A (de) 1967-02-17 1967-08-18 Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates

Publications (1)

Publication Number Publication Date
DK115473B true DK115473B (da) 1969-10-13

Family

ID=25690322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK63068AA DK115473B (da) 1967-02-17 1968-02-16 Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.

Country Status (13)

Country Link
US (1) US3652543A (fr)
AT (1) AT275533B (fr)
BE (1) BE710872A (fr)
CH (2) CH481110A (fr)
DE (2) DE1668915A1 (fr)
DK (1) DK115473B (fr)
ES (1) ES350574A1 (fr)
FR (2) FR1561479A (fr)
GB (2) GB1221324A (fr)
IL (1) IL29485A (fr)
NL (1) NL6802257A (fr)
NO (1) NO124369B (fr)
SE (1) SE342043B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT289812B (de) * 1968-08-09 1971-05-10 Geigy Ag J R Verfahren zur Herstellung des neuen 2-Methyl-7-chlor-2,3,4,5-tetrahydro-1H-3-benzazepins sowie seiner Säureadditionssalze
DE2016136A1 (de) * 1970-04-04 1971-10-14 C H Boehnnger Sohn, 6507 Ingel heim Neue 7 Acyl 1,2,4,5 tetrahydro (3H) 3 benzazepine
DE2143204C3 (de) * 1971-08-28 1979-09-27 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt N-Fluoralkyl-phenylisopropylamin-Derivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis
FR2171879A1 (en) * 1972-02-14 1973-09-28 Pennwalt Corp 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc
EP0161350A1 (fr) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Procédé de préparation de benzazépines
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
JPH0681745B2 (ja) * 1986-01-16 1994-10-19 シェリング・コ−ポレ−ション 縮合ベンゾアゼピン
US4973586A (en) * 1986-01-16 1990-11-27 Schering Corporation Fused benzazepines, compositions of, and medical use thereof
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
AU617651B2 (en) * 1987-07-15 1991-12-05 Schering Corporation Fused benzazepines
EP0513174B1 (fr) * 1990-02-02 1995-08-16 Schering Corporation Derives de 4,5-cycloalcano-3-benzazepin-7-ol et leurs utilisations
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US20030220661A1 (en) * 2002-05-21 2003-11-27 Heartstent Corporation Transmyocardial implant delivery system
EP1636191A2 (fr) * 2003-06-17 2006-03-22 Arena Pharmaceuticals, Inc. Processus de preparation de benzazepines pour le traitement des maladies associées avec le recepteur 5ht2c
CN1805938B (zh) * 2003-06-17 2010-06-16 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
NZ555981A (en) 2004-12-21 2011-01-28 Arena Pharm Inc Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EP1833473B1 (fr) 2004-12-23 2009-09-09 Arena Pharmaceuticals, Inc. Compositions renfermant un modulateur des recepteurs 5ht2c et procedes d'utilisation correspondants
CA2646044A1 (fr) * 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Procedes de preparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermediaires associes
CA2670285A1 (fr) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Procedes de preparation de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et intermediaires de celle-ci
WO2009111004A1 (fr) * 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Procédés de préparation d'intermédiaires se rapportant à l'agoniste 5-ht<sb>2c</sb> (r)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1h-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
MX2013002418A (es) 2010-09-01 2013-08-01 Arena Pharm Inc Administracion de lorcaserina a individuos con daño renal.
JP2013539470A (ja) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ， インコーポレイテッド ロルカセリンと光学活性な酸との塩
BR112015007779A2 (pt) 2012-10-09 2017-07-04 Arena Pharm Inc célula de fluxo de permeabilidade e sistema de condutância hidráulica

Also Published As

Publication number Publication date
AT275533B (de) 1969-10-27
IL29485A (en) 1971-07-28
FR1561479A (fr) 1969-03-28
NO124369B (fr) 1972-04-10
FR1560654A (fr) 1969-03-21
BE710872A (fr) 1968-08-16
GB1222397A (en) 1971-02-10
GB1221324A (en) 1971-02-03
SE342043B (fr) 1972-01-24
CH488705A (de) 1970-04-15
NL6802257A (fr) 1968-08-19
DE1668915A1 (de) 1972-03-09
DE1695124A1 (de) 1970-08-20
US3652543A (en) 1972-03-28
ES350574A1 (es) 1969-11-16
CH481110A (de) 1969-11-15

Similar Documents

Publication Publication Date Title
DK115473B (da) Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.
DK130070B (da) Analogifremgangsmåde til fremstilling af 3,4-dihydroxyphenylalkanolaminer eller syreadditionssalte deraf.
DK108497C (da) Fremgangsmåde til fremstilling af substituerede 6,7-benzomorphaner eller syreadditionssalte deraf.
DK123022B (da) Analogifremgangsmåde til fremstilling af amino-monohalogen-phenylethanolaminer eller syreadditionssalte deraf.
DK124404B (da) Fremgangsmåde til fremstilling af 2-arylamino-1,3-diazacycloalkener-(2) eller syreadditionssalte deraf.
DK120400B (da) Analogifremgangsmåde til fremstilling af 1-(3,5-dihalogen-4-hydroxyphenyl)-2-(2-phenoxy- eller 2-phenylalkyl-isopropylamino)-propanoler eller syreadditionssalte deraf.
DK131721B (da) Analogifremgangsmåde til fremstilling af adamantanylaminer eller 3,5,7-trimethylhomologe eller syreadditionssalte deraf.
DK115846B (da) Fremgangsmåde til fremstilling af (3,5-diamino-6-halogenpyrazinoyl)guanidin- eller (3,5-diamino-6-halogenpyrazinamido)guanidin-forbindelser eller syreadditionssalte deraf.
DK121367B (da) Analogifremgangsmåde til fremstilling af 3,3-difenylallylaminderivater eller syreadditionssalte deraf.
DK121123B (da) Fremgangsmåde til fremstilling af 1,2-dihydro-4-phenyl-quinazolin-3-oxider eller syradditionssalte deraf.
DK117425B (da) Fremgangsmåde til fremstilling af heterocyclisk substituerede hydrazino-imidazoliner-(2) eller syreadditionssalte deraf.
DK135231B (da) Analogifremgangsmåde til fremstilling af basisk substituerede 2,3-cis, trans-diphenylcyclopropanderivater eller syreadditionssalte deraf.
DK118663B (da) Analogifremgangsmåde til fremstilling af basisk substituerede derivater af 5,6-dihydro-dibenz-[b,e]-azepin-6, 11-dion-11-oxim eller syreadditionssalte deraf.
DK127424B (da) Analogifremgangsmåde til fremstilling af 4-aryl-1-(4,4-diarylbutyl)-4-hydroxypiperidiner eller syreadditionssalte deraf.
DK118246B (da) Analogifremgangsmåde til fremstilling af 2-isothiuroniummethyl-3-carboxylsyreamido-quinozalin-di-N-oxid-(1,4)-halogenider.
DK138740B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller syreadditionssalte deraf.
DK127331B (da) Analogifremgangsmåde til fremstilling af aryloxyisoalkyl-Δ&lt;2&gt;-imidazoliner eller syreadditionssalte heraf.
DK136117B (da) Fremgangsmåde til fremstilling af 5-hydroxy-5-phenyl-2,3-dihydro-5H-imidazo(2,1-a)-isoindoler eller syreadditionssalte heraf.
DK130587B (da) Analogifremgangsmåde til fremstilling af difenylpyridazoner eller syreadditionssalt deraf.
DK121125B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller syreadditionssalte deraf.
DK118657B (da) Analogifremgangsmåde til fremstilling af 3&#39;,4&#39;,5&#39;-trimethoxy-3-aminoacrylophenoner eller syreadditionssalte deraf.
DK115771B (da) Fremgangsmåde til fremstilling af (3,5-diamino-6-halogenpyrazinoyl) guanidin- eller (3,5-diamino-6-halogenpyrazinamido) guanidin-forbindelser eller syreadditionssalte deraf.
DK137674B (da) Analogifremgangsmåde til fremstilling af monophenylsubstituerede oxazoler eller syreadditionssalte deraf.
DK126781B (da) Analogifremgangsmåde til fremstilling af pyrrolidinoguanidinforbindelser eller syreadditionssalte deraf.
DK119826B (da) Fremgangsmåde til fremstilling af α-6-deoxytetracyclin, α-6-deoxy-5-oxytetracyclin eller syreadditionssalte deraf.