DK1149109T3 - Fremgangsmåde til afbeskyttelse af oligonukleotider - Google Patents

Fremgangsmåde til afbeskyttelse af oligonukleotider

Info

Publication number
DK1149109T3
DK1149109T3 DK00907140T DK00907140T DK1149109T3 DK 1149109 T3 DK1149109 T3 DK 1149109T3 DK 00907140 T DK00907140 T DK 00907140T DK 00907140 T DK00907140 T DK 00907140T DK 1149109 T3 DK1149109 T3 DK 1149109T3
Authority
DK
Denmark
Prior art keywords
oligonucleotide
substrate
protecting groups
phosphate protecting
attached
Prior art date
Application number
DK00907140T
Other languages
Danish (da)
English (en)
Inventor
Anila Bhan
Lars Holmberg
Original Assignee
Ge Healthcare Bio Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences filed Critical Ge Healthcare Bio Sciences
Application granted granted Critical
Publication of DK1149109T3 publication Critical patent/DK1149109T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK00907140T 1999-02-05 2000-02-05 Fremgangsmåde til afbeskyttelse af oligonukleotider DK1149109T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11857599P 1999-02-05 1999-02-05
PCT/US2000/002845 WO2000046231A1 (en) 1999-02-05 2000-02-05 Method for deprotecting oligonucleotides

Publications (1)

Publication Number Publication Date
DK1149109T3 true DK1149109T3 (da) 2010-01-11

Family

ID=22379444

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00907140T DK1149109T3 (da) 1999-02-05 2000-02-05 Fremgangsmåde til afbeskyttelse af oligonukleotider

Country Status (10)

Country Link
US (1) US6887990B1 (no)
EP (1) EP1149109B1 (no)
JP (1) JP4705716B2 (no)
AT (1) ATE443071T1 (no)
AU (1) AU767509B2 (no)
CA (1) CA2361079C (no)
DE (1) DE60042962D1 (no)
DK (1) DK1149109T3 (no)
NO (1) NO20013804L (no)
WO (1) WO2000046231A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE246041T1 (de) 1998-02-11 2003-08-15 Univ Houston Office Of Technol Vorrichtung zur durchführung chemischer und biochemischer reaktionen unter anwendung von photoerzeugten reagenzien
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
JP2004517089A (ja) 2000-12-05 2004-06-10 アベシア・リミテッド ホスホロチオエートオリゴヌクレオチドの調製方法
US6768005B2 (en) 2000-12-20 2004-07-27 Avecia Limited Process
ATE312841T1 (de) 2001-03-08 2005-12-15 Applera Corp Verfahren zum entschützen von oligonukleotide
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US20030153741A1 (en) * 2002-02-08 2003-08-14 Marek Kwiatkowski Methods for separating oligonucleotides
US8138330B2 (en) * 2006-09-11 2012-03-20 Sigma-Aldrich Co. Llc Process for the synthesis of oligonucleotides
US8513404B2 (en) * 2008-04-24 2013-08-20 Nitto Denko Avecia, Inc. Process for the manufacture of oligonucleotides
WO2021045141A1 (ja) * 2019-09-04 2021-03-11 神戸天然物化学株式会社 オリゴヌクレオチドの脱保護方法
KR20220079832A (ko) 2019-10-11 2022-06-14 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
US20230312635A1 (en) 2020-01-29 2023-10-05 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
CN115003680A (zh) 2020-01-29 2022-09-02 住友化学株式会社 制备核酸寡聚物的方法
KR20220160010A (ko) 2020-03-27 2022-12-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN115867559A (zh) 2020-07-09 2023-03-28 住友化学株式会社 核酸寡聚物的制造方法
KR20230074205A (ko) 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
WO2023054350A1 (ja) 2021-09-28 2023-04-06 住友化学株式会社 精製ジクロロ酢酸の製造方法
EP4201947A1 (en) * 2021-12-22 2023-06-28 F. Hoffmann-La Roche AG Process for the backbone deprotection of oligonucleotides containing a terminal alkyl phosphonate group
CN114573652A (zh) * 2022-03-15 2022-06-03 通用生物(滁州)有限公司 药用核酸合成工艺
WO2024053578A1 (ja) * 2022-09-07 2024-03-14 株式会社日本触媒 核酸の製造方法、不純物の除去方法及び不純物が少ない核酸

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4417046A (en) * 1981-08-24 1983-11-22 Eli Lilly And Company Process for isolating oligonucleotide product from a coupling reaction mixture
US4426517A (en) * 1981-08-24 1984-01-17 Eli Lilly And Company Process for de-cyanoethylating blocked nucleotides
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
US5362866A (en) * 1983-09-02 1994-11-08 Molecular Biosystems, Inc. Oligonucleotide polymeric support system with an oxidation cleavable link
EP0155950B1 (en) * 1983-09-02 1990-01-17 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
US4672110A (en) * 1983-11-29 1987-06-09 Northwestern University Method of deprotecting polynucleotide trimethylethyl phosphotriesters
JPS6242997A (ja) * 1985-08-19 1987-02-24 Akira Kaji ヌクレオシドアルキルホスホネイトの製造方法
SE9003743D0 (sv) 1990-11-26 1990-11-26 Pharmacia Ab Method and means for oligonucleotide synthesis
DE19627898A1 (de) * 1996-07-11 1998-01-15 Hoechst Ag Festphasensynthese von Oligonucleotiden
US6127533A (en) * 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US6465628B1 (en) * 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds

Also Published As

Publication number Publication date
CA2361079C (en) 2010-05-25
NO20013804D0 (no) 2001-08-03
ATE443071T1 (de) 2009-10-15
JP4705716B2 (ja) 2011-06-22
JP2002536381A (ja) 2002-10-29
US6887990B1 (en) 2005-05-03
EP1149109A1 (en) 2001-10-31
DE60042962D1 (de) 2009-10-29
AU2868700A (en) 2000-08-25
EP1149109B1 (en) 2009-09-16
CA2361079A1 (en) 2000-08-10
NO20013804L (no) 2001-08-22
WO2000046231A1 (en) 2000-08-10
AU767509B2 (en) 2003-11-13

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