DK1144425T3 - Derivater af monosaccharider som celleadhæsionsinhibitorer - Google Patents

Derivater af monosaccharider som celleadhæsionsinhibitorer

Info

Publication number
DK1144425T3
DK1144425T3 DK00900087T DK00900087T DK1144425T3 DK 1144425 T3 DK1144425 T3 DK 1144425T3 DK 00900087 T DK00900087 T DK 00900087T DK 00900087 T DK00900087 T DK 00900087T DK 1144425 T3 DK1144425 T3 DK 1144425T3
Authority
DK
Denmark
Prior art keywords
monosaccharides
derivatives
cell adhesion
adhesion inhibitors
inhibitors
Prior art date
Application number
DK00900087T
Other languages
Danish (da)
English (en)
Inventor
Sudershan K Arora
Madan P Tanwar
Jang Bahadur Gupta
Geeta Sharma
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of DK1144425T3 publication Critical patent/DK1144425T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK00900087T 1999-01-12 2000-01-10 Derivater af monosaccharider som celleadhæsionsinhibitorer DK1144425T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22915599A 1999-01-12 1999-01-12
US09/411,357 US6329344B1 (en) 1998-10-22 1999-10-01 Derivatives of monosaccharides as cell adhesion inhibitors
EP00900087A EP1144425B1 (en) 1999-01-12 2000-01-10 Derivatives of monosaccharides as cell adhesion inhibitors

Publications (1)

Publication Number Publication Date
DK1144425T3 true DK1144425T3 (da) 2004-10-18

Family

ID=26922990

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00900087T DK1144425T3 (da) 1999-01-12 2000-01-10 Derivater af monosaccharider som celleadhæsionsinhibitorer

Country Status (29)

Country Link
US (1) US6329344B1 (es)
EP (1) EP1144425B1 (es)
JP (1) JP2002534529A (es)
CN (1) CN1254478C (es)
AR (1) AR033939A1 (es)
AT (1) ATE269349T1 (es)
AU (1) AU767948B2 (es)
BG (1) BG105795A (es)
BR (1) BR0007489A (es)
CA (1) CA2359980A1 (es)
CO (1) CO5170511A1 (es)
CZ (1) CZ20012541A3 (es)
DE (1) DE60011568T2 (es)
DK (1) DK1144425T3 (es)
ES (1) ES2223447T3 (es)
HK (1) HK1041006B (es)
HR (1) HRP20010527B1 (es)
HU (1) HUP0200097A3 (es)
ID (1) ID30259A (es)
IL (2) IL144274A0 (es)
MA (1) MA25679A1 (es)
MY (1) MY122723A (es)
NZ (2) NZ512851A (es)
PA (1) PA8489601A1 (es)
PT (1) PT1144425E (es)
SK (1) SK284568B6 (es)
TR (1) TR200102031T2 (es)
WO (1) WO2000042053A1 (es)
YU (1) YU50101A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152397A (en) * 2002-10-21 2009-02-11 Hadasit Med Res Service Compositions and compounds for the treatment of hyperglycemia
AU2003202767A1 (en) * 2003-02-12 2004-09-06 Ranbaxy Laboratories Limited Preparation of monosaccharide derivatives
WO2004099229A1 (en) * 2003-05-06 2004-11-18 Ranbaxy Laboratories Limited Process for the synthesis of base addition salts of 2,3-0-isopropylidene-1-0-substituted-5,6-dideoxy-5-n- (4-(2-hydroxy-2-oxoethyl)-phenylaminocarbonyl) amino-l-gulofuranosides
SG141430A1 (en) 2003-05-30 2008-04-28 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
WO2005030735A1 (en) * 2003-09-25 2005-04-07 Ranbaxy Laboratories Limited Triazines derivatives as cell adhesion inhibitors
WO2005092908A1 (en) * 2004-03-18 2005-10-06 Ranbaxy Laboratories Limited Base addition salts of monosaccharides derivatives as inhibitors of airway hyper reactivity and airway inflammation
WO2005092907A2 (en) * 2004-03-26 2005-10-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
WO2005100373A2 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
US20090221515A1 (en) * 2004-09-02 2009-09-03 Viswajanani Jitendra Sattigeri Monosaccharide derivatives
WO2007063356A2 (en) * 2004-12-22 2007-06-07 Ranbaxy Laboratories Limited Derivatives of pentose monosaccharides as anti-inflammatory compounds
WO2007010499A2 (en) * 2005-07-22 2007-01-25 Ranbaxy Laboratories Limited Derivatives of monosaccharides for the treatment of copd and allergic rhinitis
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US20080114031A1 (en) * 2006-03-29 2008-05-15 Sattigeri Viswajanani J Monosaccharide derivatives
US7790689B2 (en) * 2006-05-30 2010-09-07 Ranbaxy Laboratories Limited Monosaccharide derivatives
EP1953170A1 (en) * 2006-10-03 2008-08-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory agents
CN105367612A (zh) * 2014-08-13 2016-03-02 中国药科大学 龙脷叶由来天然产物丁基2-脱氧-3，6-脱水-β-D-阿拉伯糖呋喃糖苷的全合成方法
US20220356150A1 (en) * 2021-04-30 2022-11-10 Evoco Limited Biobased diisocyanates, and process for preparation of same
WO2024135721A1 (ja) * 2022-12-21 2024-06-27 田辺三菱製薬株式会社 製造中間体の製造方法、その製造中間体及びそれらを用いた架橋型人工核酸中間体の製造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715121A (en) 1950-09-09 1955-08-09 American Home Prod Alkyl sugar derivatives and their preparation
US4056322A (en) 1973-12-14 1977-11-01 Strategic Medical Research Corporation Preparation of ethers of monosaccharides
DE2936240A1 (de) * 1979-09-07 1981-03-26 Bayer Ag, 51373 Leverkusen Verfahren zur herstellung bekannter und neuer 6-amino-6-desoxy-2,3-0-isopropyliden-(alpha)-l-sorbofuranose-derivate sowie neue zwischenprodukte des verfahrens
US4735934A (en) 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5298494A (en) 1989-01-09 1994-03-29 Greenwich Pharmaceuticals Incorporated Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
US5010058A (en) 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
US5192746A (en) 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
IL100833A0 (en) 1991-02-20 1992-09-06 Greenwich Pharma Method for synthesis of ethereally substituted blocked monosaccharides
US5360792A (en) 1991-12-20 1994-11-01 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
US5360794A (en) 1992-08-03 1994-11-01 Medicarb Inc. Disubstituted and deoxy disubstituted derivatives of α-D-mannofuranosides and β-L-gulofuranosides having anti-inflammatory and anti-proliferative activity
US5367062A (en) 1992-08-21 1994-11-22 Medicarb Inc. Disubstituted and deoxydisubstituted derivatives of α-d-lyxofuranosides having anti-inflammatory and anti-proliferative activity
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
WO1995010296A1 (en) * 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors
US5637570A (en) 1995-05-09 1997-06-10 Chemora Pharmochem Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid having anti-cancer, anti-inflammatory and anti-proliferative activity
WO1997015585A1 (fr) * 1995-10-26 1997-05-01 Kanebo, Ltd. Derives de la fucose, medicaments dont ils forment le principe actif, et leurs intermediaires de fabrication
US5824657A (en) 1997-03-18 1998-10-20 Cubist Pharmaceuticals, Inc. Aminoacyl sulfamides for the treatment of hyperproliferative disorders

Also Published As

Publication number Publication date
ATE269349T1 (de) 2004-07-15
TR200102031T2 (tr) 2001-12-21
CA2359980A1 (en) 2000-07-20
HRP20010527B1 (en) 2005-06-30
BR0007489A (pt) 2002-01-02
IL144274A (en) 2007-05-15
MA25679A1 (fr) 2003-04-01
IL144274A0 (en) 2002-05-23
SK284568B6 (sk) 2005-06-02
HUP0200097A2 (hu) 2002-05-29
ES2223447T3 (es) 2005-03-01
AR033939A1 (es) 2004-01-21
NZ512851A (en) 2004-02-27
HRP20010527A2 (en) 2002-08-31
HUP0200097A3 (en) 2003-03-28
WO2000042053A1 (en) 2000-07-20
DE60011568D1 (de) 2004-07-22
CO5170511A1 (es) 2002-06-27
YU50101A (sh) 2005-07-19
JP2002534529A (ja) 2002-10-15
HK1041006B (zh) 2005-02-04
DE60011568T2 (de) 2005-08-18
MY122723A (en) 2006-04-29
PA8489601A1 (es) 2000-09-29
CZ20012541A3 (cs) 2002-02-13
PT1144425E (pt) 2004-10-29
EP1144425A1 (en) 2001-10-17
HK1041006A1 (en) 2002-06-28
EP1144425B1 (en) 2004-06-16
AU767948B2 (en) 2003-11-27
ID30259A (id) 2001-11-15
NZ527482A (en) 2005-02-25
CN1254478C (zh) 2006-05-03
SK9962001A3 (en) 2002-02-05
AU1886000A (en) 2000-08-01
BG105795A (en) 2002-05-31
US6329344B1 (en) 2001-12-11
CN1343212A (zh) 2002-04-03

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