DK1129180T3 - Kemisk moduficerede mutante serinhydrolaser - Google Patents

Kemisk moduficerede mutante serinhydrolaser

Info

Publication number
DK1129180T3
DK1129180T3 DK99964973T DK99964973T DK1129180T3 DK 1129180 T3 DK1129180 T3 DK 1129180T3 DK 99964973 T DK99964973 T DK 99964973T DK 99964973 T DK99964973 T DK 99964973T DK 1129180 T3 DK1129180 T3 DK 1129180T3
Authority
DK
Denmark
Prior art keywords
cysteine
serine hydrolases
chemically modified
group
modified
Prior art date
Application number
DK99964973T
Other languages
Danish (da)
English (en)
Inventor
John Bryan Jones
Michael Dickman
Original Assignee
Univ Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toronto filed Critical Univ Toronto
Application granted granted Critical
Publication of DK1129180T3 publication Critical patent/DK1129180T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK99964973T 1998-11-10 1999-11-09 Kemisk moduficerede mutante serinhydrolaser DK1129180T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10775898P 1998-11-10 1998-11-10
US11306198P 1998-12-21 1998-12-21
PCT/US1999/026586 WO2000028007A2 (en) 1998-11-10 1999-11-09 Chemically modified mutant serine hydrolases

Publications (1)

Publication Number Publication Date
DK1129180T3 true DK1129180T3 (da) 2009-08-24

Family

ID=26805118

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99964973T DK1129180T3 (da) 1998-11-10 1999-11-09 Kemisk moduficerede mutante serinhydrolaser

Country Status (9)

Country Link
US (4) US20050282248A1 (de)
EP (1) EP1129180B1 (de)
JP (1) JP4932990B2 (de)
AT (1) ATE433485T1 (de)
AU (1) AU772427B2 (de)
CA (1) CA2348014A1 (de)
DE (1) DE69940978D1 (de)
DK (1) DK1129180T3 (de)
WO (1) WO2000028007A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
BR9909130A (pt) 1998-03-26 2000-12-19 Procter & Gamble Variantes de protease de serina tendo substituições de amino-ácido
ATE433485T1 (de) 1998-11-10 2009-06-15 Univ Toronto Chemisch modifizierte mutante serinhydrolasen
MXPA01010896A (es) * 1999-04-28 2003-06-24 Genencor Int Antagonistas cataliticos especificamente dirigidos al objetivo y usos de los mismos.
MXPA02000840A (es) 1999-07-22 2002-07-30 Procter & Gamble Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas.
CZ2002220A3 (cs) 1999-07-22 2002-05-15 The Procter & Gamble Company Varianty subtilisinové proteasy s delecemi a substitucemi aminokyselin v definovaných epitopových regionech
CN1372593A (zh) * 1999-07-22 2002-10-02 宝洁公司 具有空间保护的表位区域的蛋白酶缀合物
CA2379729A1 (en) 1999-07-22 2001-02-01 The Procter & Gamble Company Protease conjugates having sterically protected clip sites
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
US7202070B2 (en) 2000-10-31 2007-04-10 Biocatalytics, Inc. Method for reductive amination of a ketone using a mutated enzyme
DE10121463A1 (de) * 2001-05-02 2003-02-27 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
EP1359225B1 (de) * 2002-04-08 2006-11-15 Degussa AG Verfahren zur Bestimmung der Syntheseaktivität von Hydrolasen
EP1354960A1 (de) * 2002-04-08 2003-10-22 Degussa AG Verfahren zur Bestimmung der Syntheseaktivität von Hydrolasen
EP3307848B1 (de) 2015-06-10 2019-03-06 Merck Patent GmbH Chirale dotierstoffe mit nortricyclan-einheit

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972682A (en) 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US5244791A (en) 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
US5155033A (en) 1989-01-06 1992-10-13 Genencor, Inc. Subtilisins modified at position 225 resulting in a shift in catalytic activity
PT89702B (pt) 1988-02-11 1994-04-29 Gist Brocades Nv Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem
US5116741A (en) * 1988-04-12 1992-05-26 Genex Corporation Biosynthetic uses of thermostable proteases
DK97190D0 (da) 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
CA2087342C (en) 1990-08-09 2003-12-23 Lars Abrahmsen Serine protease variants having peptide ligase activity
US5629173A (en) * 1990-08-09 1997-05-13 Genentech, Inc. Methods of use of serine protease variants having peptide ligase activity
US5316935A (en) * 1992-04-06 1994-05-31 California Institute Of Technology Subtilisin variants suitable for hydrolysis and synthesis in organic media
US5837516A (en) 1995-03-03 1998-11-17 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing basic residues
US6946280B1 (en) 1996-03-29 2005-09-20 Genencor International, Inc. Enzyme multimer and process of producing same
EP0942962B1 (de) * 1996-11-26 2006-12-27 Genencor International, Inc. Chemisch modifizierte enzyme
AR015977A1 (es) 1997-10-23 2001-05-30 Genencor Int Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
DK1047445T3 (da) * 1998-01-23 2013-11-11 Univ Toronto Modificerede enzymer og anvendelse heraf til peptidsyntese
EP1064019B1 (de) * 1998-01-23 2010-11-03 The Governing Council Of The University Of Toronto Chemisch modifizierte enzyme und methoden zu ihrer herstellung und zum screeningder enzyme
DE69939538D1 (de) * 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
ATE433485T1 (de) 1998-11-10 2009-06-15 Univ Toronto Chemisch modifizierte mutante serinhydrolasen
EP1141335B1 (de) * 1998-12-21 2009-08-05 Genencor International, Inc. Chemisch modifizierte enzymen mit mehrfachgeladenen varianten

Also Published As

Publication number Publication date
JP2002529078A (ja) 2002-09-10
WO2000028007A3 (en) 2000-07-27
US20050282248A1 (en) 2005-12-22
AU3099000A (en) 2000-05-29
US20090075329A1 (en) 2009-03-19
ATE433485T1 (de) 2009-06-15
AU772427B2 (en) 2004-04-29
US8148128B2 (en) 2012-04-03
EP1129180A2 (de) 2001-09-05
US20120295329A1 (en) 2012-11-22
JP4932990B2 (ja) 2012-05-16
DE69940978D1 (de) 2009-07-23
US8357524B2 (en) 2013-01-22
EP1129180B1 (de) 2009-06-10
US20120156721A1 (en) 2012-06-21
CA2348014A1 (en) 2000-05-18
WO2000028007A2 (en) 2000-05-18

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