DK1121349T3 - Substituerede thiadiazolsulfonamider som interleukin-1-beta-inhibitorer - Google Patents
Substituerede thiadiazolsulfonamider som interleukin-1-beta-inhibitorerInfo
- Publication number
- DK1121349T3 DK1121349T3 DK99947450T DK99947450T DK1121349T3 DK 1121349 T3 DK1121349 T3 DK 1121349T3 DK 99947450 T DK99947450 T DK 99947450T DK 99947450 T DK99947450 T DK 99947450T DK 1121349 T3 DK1121349 T3 DK 1121349T3
- Authority
- DK
- Denmark
- Prior art keywords
- interleukin
- beta inhibitors
- substituted thiadiazole
- sulfonamides
- thiadiazole sulfonamides
- Prior art date
Links
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 title 1
- 102000003777 Interleukin-1 beta Human genes 0.000 title 1
- 108090000193 Interleukin-1 beta Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- LBLZPOGZQOBQKC-UHFFFAOYSA-N thiadiazole-4-sulfonamide Chemical class NS(=O)(=O)C1=CSN=N1 LBLZPOGZQOBQKC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19847823A DE19847823A1 (de) | 1998-10-16 | 1998-10-16 | Substituierte Thiadiazolsulfonamide |
| PCT/EP1999/007301 WO2000023430A1 (de) | 1998-10-16 | 1999-10-02 | Substituierte thiadiazolsulfonamide als interleukin-1-beta-hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1121349T3 true DK1121349T3 (da) | 2004-07-12 |
Family
ID=7884736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99947450T DK1121349T3 (da) | 1998-10-16 | 1999-10-02 | Substituerede thiadiazolsulfonamider som interleukin-1-beta-inhibitorer |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6218412B1 (https=) |
| EP (1) | EP1121349B1 (https=) |
| JP (1) | JP4733270B2 (https=) |
| AR (1) | AR023909A1 (https=) |
| AT (1) | ATE263158T1 (https=) |
| AU (1) | AU6088799A (https=) |
| DE (2) | DE19847823A1 (https=) |
| DK (1) | DK1121349T3 (https=) |
| ES (1) | ES2214885T3 (https=) |
| PT (1) | PT1121349E (https=) |
| WO (1) | WO2000023430A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US7851418B2 (en) * | 2005-06-03 | 2010-12-14 | Exxonmobil Research And Engineering Company | Ashless detergents and formulated lubricating oil containing same |
| WO2009021052A1 (en) * | 2007-08-06 | 2009-02-12 | University Of Kentucky Research Foundation | Polypeptides, systems, and methods useful for detecting glucose |
| RU2434856C1 (ru) * | 2010-10-15 | 2011-11-27 | Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) | 5-амино-3-(2-нитроксипропил)-1,2,4-тиадиазолы |
| EP2628734A4 (en) * | 2010-10-15 | 2014-04-23 | Federalnoe G Bydzhetnoe Uchrezhdenie Nauki Inst Fiziol Aktivnikh Veschestv Rossiiskoi Akademii Nauk | DERIVATIVES OF 5-AMINO - [1,2,4] THIADIAZOLE |
| CA2877026A1 (en) * | 2012-05-18 | 2013-11-21 | Amgen Inc. | Method for the preparation of thiadiazoles |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873239A (en) | 1987-01-29 | 1989-10-10 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylthiadiazolylsulfonamides and derivatives |
| US4985450A (en) | 1987-01-29 | 1991-01-15 | Tegeler John J | Arylthiadiazolylsulfonamides and derivatives |
| US4758578A (en) * | 1987-01-29 | 1988-07-19 | Hoechst Roussel Pharmaceuticals, Inc. | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use |
| ES2124800T3 (es) | 1993-01-08 | 1999-02-16 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 1 beta. |
| AU702887B2 (en) * | 1995-10-31 | 1999-03-11 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
| EP0900791A1 (en) * | 1995-12-27 | 1999-03-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
| JPH09235276A (ja) * | 1995-12-27 | 1997-09-09 | Takeda Chem Ind Ltd | オキサゾール誘導体、その製造法および用途 |
| KR20000057137A (ko) * | 1996-11-19 | 2000-09-15 | 스티븐 엠. 오드레 | 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제 |
-
1998
- 1998-10-16 DE DE19847823A patent/DE19847823A1/de not_active Withdrawn
-
1999
- 1999-10-02 DE DE59909049T patent/DE59909049D1/de not_active Expired - Lifetime
- 1999-10-02 AT AT99947450T patent/ATE263158T1/de active
- 1999-10-02 AU AU60887/99A patent/AU6088799A/en not_active Abandoned
- 1999-10-02 WO PCT/EP1999/007301 patent/WO2000023430A1/de not_active Ceased
- 1999-10-02 PT PT99947450T patent/PT1121349E/pt unknown
- 1999-10-02 EP EP99947450A patent/EP1121349B1/de not_active Expired - Lifetime
- 1999-10-02 ES ES99947450T patent/ES2214885T3/es not_active Expired - Lifetime
- 1999-10-02 JP JP2000577158A patent/JP4733270B2/ja not_active Expired - Fee Related
- 1999-10-02 DK DK99947450T patent/DK1121349T3/da active
- 1999-10-14 AR ARP990105202A patent/AR023909A1/es active IP Right Grant
- 1999-10-14 US US09/418,026 patent/US6218412B1/en not_active Expired - Lifetime
-
2001
- 2001-02-09 US US09/779,823 patent/US6503934B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2214885T3 (es) | 2004-09-16 |
| DE19847823A1 (de) | 2000-04-20 |
| US6503934B2 (en) | 2003-01-07 |
| ATE263158T1 (de) | 2004-04-15 |
| AU6088799A (en) | 2000-05-08 |
| JP2002527510A (ja) | 2002-08-27 |
| EP1121349B1 (de) | 2004-03-31 |
| US20010039350A1 (en) | 2001-11-08 |
| JP4733270B2 (ja) | 2011-07-27 |
| DE59909049D1 (en) | 2004-05-06 |
| AR023909A1 (es) | 2002-09-04 |
| WO2000023430A1 (de) | 2000-04-27 |
| US6218412B1 (en) | 2001-04-17 |
| EP1121349A1 (de) | 2001-08-08 |
| PT1121349E (pt) | 2004-08-31 |
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