DK1121137T3 - Fremgangsmåde til udryddelse af tumorer og tumorassocierede endotelceller under anvendelse af adenovirus af adenovirus-mutanter - Google Patents
Fremgangsmåde til udryddelse af tumorer og tumorassocierede endotelceller under anvendelse af adenovirus af adenovirus-mutanterInfo
- Publication number
- DK1121137T3 DK1121137T3 DK99953196T DK99953196T DK1121137T3 DK 1121137 T3 DK1121137 T3 DK 1121137T3 DK 99953196 T DK99953196 T DK 99953196T DK 99953196 T DK99953196 T DK 99953196T DK 1121137 T3 DK1121137 T3 DK 1121137T3
- Authority
- DK
- Denmark
- Prior art keywords
- adenovirus
- endothelial cells
- mutants
- eradication
- tumors
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 241000701161 unidentified adenovirus Species 0.000 title abstract 3
- 210000002889 endothelial cell Anatomy 0.000 title abstract 2
- 230000008029 eradication Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000010076 replication Effects 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004925 microvascular endothelial cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10570198P | 1998-10-26 | 1998-10-26 | |
| US12130099P | 1999-02-23 | 1999-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1121137T3 true DK1121137T3 (da) | 2005-11-14 |
Family
ID=26802854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99953196T DK1121137T3 (da) | 1998-10-26 | 1999-10-15 | Fremgangsmåde til udryddelse af tumorer og tumorassocierede endotelceller under anvendelse af adenovirus af adenovirus-mutanter |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20020037274A1 (da) |
| EP (1) | EP1121137B1 (da) |
| JP (1) | JP2004517798A (da) |
| CN (1) | CN1333689A (da) |
| AT (1) | ATE299708T1 (da) |
| AU (1) | AU775611B2 (da) |
| CA (1) | CA2348634A1 (da) |
| DE (1) | DE69926251T2 (da) |
| DK (1) | DK1121137T3 (da) |
| ES (1) | ES2245831T3 (da) |
| WO (1) | WO2000024408A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040175362A1 (en) * | 1999-05-12 | 2004-09-09 | Curiel David T. | Infectivity-enhanced conditionally-replicative adenovirus and uses thereof |
| WO2002054851A2 (en) * | 2001-01-12 | 2002-07-18 | Sbarro Institute For Cancer Research And Molecular Medicine | Inhibition of pathological angiogenesis in vivo |
| US7906311B2 (en) * | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
| US20040191761A1 (en) * | 2003-03-27 | 2004-09-30 | Routes John M. | Modified adenoviral E1A constructs and methods of use thereof |
| KR100746122B1 (ko) | 2004-05-10 | 2007-08-03 | 연세대학교 산학협력단 | Ｒｂ-결합능이 상실된 개선된 종양세포-특이 세포살상능을 나타내는 재조합 아데노바이러스 |
| RU2482189C2 (ru) | 2007-01-30 | 2013-05-20 | Трансген С.А. | Полипептиды е2 папилломавируса, применяемые для вакцинации |
| AU2010206195B2 (en) | 2009-01-20 | 2016-03-10 | Transgene Sa | Soluble ICAM-1 as biomarker for prediction of therapeutic response |
| NZ595290A (en) | 2009-03-24 | 2012-09-28 | Transgene Sa | Biomarker for monitoring patients |
| US20120058493A1 (en) | 2009-04-17 | 2012-03-08 | Bruce Acres | Biomarker for monitoring patients |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| MX337287B (es) | 2009-07-10 | 2016-02-22 | Transgene Sa | Biomarcador para seleccionar pacientes y metodos relacionados. |
| CN109134640A (zh) | 2012-10-23 | 2019-01-04 | 爱默蕾大学 | Gm-csf和il-4轭合物、组合物以及与其相关的方法 |
| EP2971008B1 (en) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Oncolytic adenovirus compositions |
| CA3013637A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0931830T3 (da) * | 1993-02-16 | 2001-06-11 | Onyx Pharma Inc | Cytopatiske vira til terapi og profylakse af neoplasi |
| US5801029A (en) * | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| AU751259B2 (en) * | 1997-12-12 | 2002-08-08 | Onyx Pharmaceuticals, Inc. | Selective killing and diagnosis of p53+ neoplastic cells |
| US7078030B2 (en) * | 1999-11-15 | 2006-07-18 | Onyx Pharmaceuticals, Inc | Oncolytic adenovirus |
| EP1230378B1 (en) * | 1999-11-15 | 2007-06-06 | Onyx Pharmaceuticals, Inc. | An oncolytic adenovirus |
-
1999
- 1999-10-01 US US09/410,462 patent/US20020037274A1/en not_active Abandoned
- 1999-10-15 CN CN99815732A patent/CN1333689A/zh active Pending
- 1999-10-15 DK DK99953196T patent/DK1121137T3/da active
- 1999-10-15 AU AU65187/99A patent/AU775611B2/en not_active Ceased
- 1999-10-15 JP JP2000578017A patent/JP2004517798A/ja active Pending
- 1999-10-15 DE DE69926251T patent/DE69926251T2/de not_active Expired - Lifetime
- 1999-10-15 ES ES99953196T patent/ES2245831T3/es not_active Expired - Lifetime
- 1999-10-15 CA CA002348634A patent/CA2348634A1/en not_active Abandoned
- 1999-10-15 WO PCT/US1999/024144 patent/WO2000024408A1/en active IP Right Grant
- 1999-10-15 AT AT99953196T patent/ATE299708T1/de active
- 1999-10-15 EP EP99953196A patent/EP1121137B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1121137A1 (en) | 2001-08-08 |
| DE69926251D1 (de) | 2005-08-25 |
| WO2000024408A1 (en) | 2000-05-04 |
| AU775611B2 (en) | 2004-08-05 |
| DE69926251T2 (de) | 2006-05-24 |
| CN1333689A (zh) | 2002-01-30 |
| US20020037274A1 (en) | 2002-03-28 |
| AU6518799A (en) | 2000-05-15 |
| CA2348634A1 (en) | 2000-05-04 |
| ES2245831T3 (es) | 2006-01-16 |
| JP2004517798A (ja) | 2004-06-17 |
| ATE299708T1 (de) | 2005-08-15 |
| EP1121137B1 (en) | 2005-07-20 |
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