DK1117798T3 - Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider - Google Patents

Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider

Info

Publication number
DK1117798T3
DK1117798T3 DK99945966T DK99945966T DK1117798T3 DK 1117798 T3 DK1117798 T3 DK 1117798T3 DK 99945966 T DK99945966 T DK 99945966T DK 99945966 T DK99945966 T DK 99945966T DK 1117798 T3 DK1117798 T3 DK 1117798T3
Authority
DK
Denmark
Prior art keywords
transcriptional activator
polypeptides
production methods
polypeptide production
nucleic acid
Prior art date
Application number
DK99945966T
Other languages
Danish (da)
English (en)
Inventor
Carsten Hjort
Peter J Punt
Den Hondel Cees A M J J Van
Frank H J Schuren
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of DK1117798T3 publication Critical patent/DK1117798T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
    • C12R2001/685—Aspergillus niger

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK99945966T 1998-10-05 1999-10-05 Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider DK1117798T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199801258 1998-10-05
PCT/DK1999/000524 WO2000020596A1 (en) 1998-10-05 1999-10-05 Fungal transcriptional activator useful in methods for producing polypeptides

Publications (1)

Publication Number Publication Date
DK1117798T3 true DK1117798T3 (da) 2007-04-10

Family

ID=8102827

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99945966T DK1117798T3 (da) 1998-10-05 1999-10-05 Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider

Country Status (8)

Country Link
EP (2) EP1783223A1 (zh)
JP (1) JP4563585B2 (zh)
CN (1) CN1329667B (zh)
AT (1) ATE349528T1 (zh)
AU (1) AU5850999A (zh)
DE (1) DE69934596T2 (zh)
DK (1) DK1117798T3 (zh)
WO (1) WO2000020596A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE469223T1 (de) * 2000-03-14 2010-06-15 Novozymes As Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden
US7229784B2 (en) 2000-09-19 2007-06-12 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
EP1613761B1 (en) 2003-03-31 2009-09-02 Novozymes Inc. Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger
EP1799827A2 (en) * 2004-10-12 2007-06-27 DSMIP Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
CA2630455A1 (en) 2005-11-29 2007-06-07 Dsm Ip Assets B.V. Dna binding site of a transcriptional activator useful in gene expression
US20100062491A1 (en) * 2007-01-05 2010-03-11 Novozymes A/S Overexpression of the Chaperone BIP in a Heterokaryon
BRPI0818788A2 (pt) * 2007-10-31 2016-10-25 Danisco Us Inc uso e produção de metaloproteases neutras, estáveis, em citrato.
CN101182352B (zh) * 2007-11-21 2010-06-09 中国科学院微生物研究所 一种转录激活因子及其编码基因与应用
EP2456872B1 (en) 2009-07-22 2017-08-30 DSM IP Assets B.V. Improved host cell for the production of a compound of interest
DK3327112T3 (en) 2012-07-19 2020-05-04 Dsm Ip Assets Bv Agse-deficient stamme
CA2916905A1 (en) 2013-07-10 2015-01-15 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
EP3172333B1 (en) 2014-07-21 2020-05-13 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
WO2016110453A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a filamentous fungal host cell
FR3046180B1 (fr) * 2015-12-28 2018-09-21 IFP Energies Nouvelles Souches mutantes de trichoderma reesei
EP3596199A1 (en) 2017-03-13 2020-01-22 DSM IP Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
EP3809852A1 (en) 2018-06-19 2021-04-28 DSM IP Assets B.V. Lipolytic enzyme variants
US20230212634A1 (en) 2020-01-14 2023-07-06 The Protein Brewery B.V. Expression of Ovalbumin and its Natural Variants
WO2023222614A1 (en) 2022-05-16 2023-11-23 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2023242273A1 (en) 2022-06-14 2023-12-21 Newmilkbuzz B.V. Expression of milk caseins in filamentous fungi
WO2024110509A1 (en) 2022-11-22 2024-05-30 Newmilkbuzz B.V Improved casein secretion by non-mammalian host cells
WO2024133849A1 (en) 2022-12-22 2024-06-27 The Protein Brewery B.V. Ovalbumin fermentation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE248925T1 (de) * 1988-01-05 2003-09-15 Roche Diagnostics Gmbh Verfahren zur herstellung von proteinen oder proteinhaltigen genprodukten
DE69532283T2 (de) * 1994-06-17 2004-09-23 Novozymes A/S EIN PILZ, IN DEM DAS areA-GEN VERÄNDERT IST, UND EIN areA-GEN AUS ASPERGILLUS ORYZAE
AU7112796A (en) * 1995-09-27 1997-04-17 Chiron Corporation Method of making a protease deficient host
EP0894126B1 (en) * 1996-03-27 2006-02-01 Novozymes A/S Alkaline protease deficient filamentous fungi

Also Published As

Publication number Publication date
CN1329667A (zh) 2002-01-02
AU5850999A (en) 2000-04-26
JP2002526112A (ja) 2002-08-20
CN1329667B (zh) 2014-05-28
WO2000020596A1 (en) 2000-04-13
EP1117798B1 (en) 2006-12-27
EP1117798A1 (en) 2001-07-25
ATE349528T1 (de) 2007-01-15
DE69934596D1 (de) 2007-02-08
DE69934596T2 (de) 2007-10-04
EP1783223A1 (en) 2007-05-09
JP4563585B2 (ja) 2010-10-13

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