DK1107965T3 - Pyridylethere og -thioethere som nikotin-acetylcholinreceptorligander og deres terapeutiske anvendelse - Google Patents
Pyridylethere og -thioethere som nikotin-acetylcholinreceptorligander og deres terapeutiske anvendelseInfo
- Publication number
- DK1107965T3 DK1107965T3 DK99942347T DK99942347T DK1107965T3 DK 1107965 T3 DK1107965 T3 DK 1107965T3 DK 99942347 T DK99942347 T DK 99942347T DK 99942347 T DK99942347 T DK 99942347T DK 1107965 T3 DK1107965 T3 DK 1107965T3
- Authority
- DK
- Denmark
- Prior art keywords
- acetylcholine receptor
- thioethers
- therapeutic use
- receptor ligands
- sup
- Prior art date
Links
- POPPVIRYGJQIOF-UHFFFAOYSA-N 2-acetyloxyethyl(trimethyl)azanium;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(=O)OCC[N+](C)(C)C.CN1CCCC1C1=CC=CN=C1 POPPVIRYGJQIOF-UHFFFAOYSA-N 0.000 title 1
- 108010009685 Cholinergic Receptors Proteins 0.000 title 1
- -1 Pyridyl ethers Chemical class 0.000 title 1
- 102000034337 acetylcholine receptors Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000003568 thioethers Chemical class 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 208000023060 memory loss Diseases 0.000 abstract 1
- 230000007659 motor function Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9785398P | 1998-08-25 | 1998-08-25 | |
| EP99942347A EP1107965B1 (en) | 1998-08-25 | 1999-08-25 | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1107965T3 true DK1107965T3 (da) | 2004-11-29 |
Family
ID=22265449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99942347T DK1107965T3 (da) | 1998-08-25 | 1999-08-25 | Pyridylethere og -thioethere som nikotin-acetylcholinreceptorligander og deres terapeutiske anvendelse |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6562847B1 (https=) |
| EP (1) | EP1107965B1 (https=) |
| JP (1) | JP2002523413A (https=) |
| AT (1) | ATE273298T1 (https=) |
| AU (1) | AU5574799A (https=) |
| CA (1) | CA2341989A1 (https=) |
| DE (1) | DE69919361T2 (https=) |
| DK (1) | DK1107965T3 (https=) |
| ES (1) | ES2226427T3 (https=) |
| PT (1) | PT1107965E (https=) |
| WO (1) | WO2000010997A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999024422A1 (en) * | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
| MXPA02002115A (es) * | 1999-09-14 | 2002-10-31 | Abbott Lab | Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. . |
| JP2001302643A (ja) * | 2000-04-21 | 2001-10-31 | Suntory Ltd | 環状アミジン化合物 |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| JP2005516927A (ja) * | 2001-12-13 | 2005-06-09 | アボット・ラボラトリーズ | 癌治療用のキナーゼ阻害剤としての３−（フェニル−アルコキシ）−５−（フェニル）−ピリジン誘導体および関連化合物 |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| AR041191A1 (es) * | 2002-08-08 | 2005-05-04 | Amgen Inc | Ligandos del receptor vanilloide y su uso en tratamientos |
| WO2004113297A2 (en) * | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AU2004257025B9 (en) * | 2003-06-27 | 2010-05-27 | Msd K.K. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| EP1670794A2 (en) | 2003-09-30 | 2006-06-21 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| EP1775295A1 (en) * | 2003-09-30 | 2007-04-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| MY139645A (en) * | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| AU2005212438A1 (en) * | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| AU2005284908B2 (en) | 2004-09-13 | 2011-12-08 | Morningside Venture Investments Limited | Biosynchronous transdermal drug delivery |
| AU2005286790A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD) |
| BRPI0515500A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| MX2007003332A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| BRPI0515482A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| US20060183763A1 (en) * | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
| US7301022B2 (en) * | 2005-02-15 | 2007-11-27 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2006113769A1 (en) * | 2005-04-15 | 2006-10-26 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| CA2618646A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US7879913B2 (en) * | 2005-06-28 | 2011-02-01 | Catholic Healthcare West | Iptakalim hydrochloride for decreasing nicotine use |
| CN103977003A (zh) | 2007-04-02 | 2014-08-13 | 帕金森氏病研究院 | 用于降低治疗的副作用的方法和组合物 |
| PE20170923A1 (es) | 2010-05-17 | 2017-07-12 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado |
| WO2013071097A1 (en) | 2011-11-11 | 2013-05-16 | Georgetown University | 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof |
| EP3461481A1 (en) | 2012-05-08 | 2019-04-03 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
| CA2944179A1 (en) * | 2013-03-27 | 2014-10-02 | Georgetown University | 2-halo-5-alkynyl-pyridyl nicotinic ligands |
| AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3382028D1 (de) * | 1982-09-30 | 1991-01-10 | Robins Co Inc A H | Kondensierte aromatische oxazepinone und sulphuranaloge, ihrer herstellung und verwendung als histamin-antagonist. |
| ZA836994B (en) * | 1982-09-30 | 1984-05-30 | Robins Co Inc A H | Fused aromatic oxazepinones and sulfur analogs thereof |
| US4667031A (en) | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| WO1999024422A1 (en) | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
| MXPA02002115A (es) | 1999-09-14 | 2002-10-31 | Abbott Lab | Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. . |
-
1999
- 1999-08-25 AU AU55747/99A patent/AU5574799A/en not_active Abandoned
- 1999-08-25 DE DE69919361T patent/DE69919361T2/de not_active Expired - Fee Related
- 1999-08-25 WO PCT/US1999/018954 patent/WO2000010997A1/en not_active Ceased
- 1999-08-25 DK DK99942347T patent/DK1107965T3/da active
- 1999-08-25 EP EP99942347A patent/EP1107965B1/en not_active Expired - Lifetime
- 1999-08-25 JP JP2000566270A patent/JP2002523413A/ja active Pending
- 1999-08-25 US US09/383,142 patent/US6562847B1/en not_active Expired - Lifetime
- 1999-08-25 AT AT99942347T patent/ATE273298T1/de not_active IP Right Cessation
- 1999-08-25 CA CA002341989A patent/CA2341989A1/en not_active Abandoned
- 1999-08-25 PT PT99942347T patent/PT1107965E/pt unknown
- 1999-08-25 ES ES99942347T patent/ES2226427T3/es not_active Expired - Lifetime
-
2003
- 2003-04-02 US US10/405,250 patent/US6888001B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2226427T3 (es) | 2005-03-16 |
| WO2000010997A1 (en) | 2000-03-02 |
| EP1107965B1 (en) | 2004-08-11 |
| DE69919361T2 (de) | 2005-09-08 |
| DE69919361D1 (de) | 2004-09-16 |
| US6562847B1 (en) | 2003-05-13 |
| ATE273298T1 (de) | 2004-08-15 |
| PT1107965E (pt) | 2004-10-29 |
| US6888001B2 (en) | 2005-05-03 |
| AU5574799A (en) | 2000-03-14 |
| EP1107965A1 (en) | 2001-06-20 |
| JP2002523413A (ja) | 2002-07-30 |
| CA2341989A1 (en) | 2000-03-02 |
| US20030207858A1 (en) | 2003-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1107965T3 (da) | Pyridylethere og -thioethere som nikotin-acetylcholinreceptorligander og deres terapeutiske anvendelse | |
| TR200000059T2 (tr) | Piridin türevleri | |
| NO20075065L (no) | Anvendelse av isoflavonforbindelser til a behandle hjertesykdom | |
| WO2002016357A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| WO2002016358A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| WO2002016356A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| DK0672041T3 (da) | Farmakologisk aktive pyridinderivater og fremgangsmåder til fremstilling deraf | |
| DK0863875T3 (da) | Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser | |
| DK256890A (da) | Benzo-piperidin-, -piperidyliden- og piperazinforbindelser, kompositioner indeholdende forbindelserne og fremgangsmaader til forbindelsernes fremstilling og anvendelse | |
| DK0934309T3 (da) | Nye pyridylalkansyreamider som cytostatiske og immunosuppressive midler | |
| SE9702483D0 (sv) | New compound | |
| NO20030301L (no) | Nye heteroarylderivater og anvendelse derav som farmasöytika | |
| DK1107973T3 (da) | Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi | |
| BG103399A (en) | New heterocycle-substituted benzamides and their application for the treatment of diseases | |
| WO2002016355A3 (en) | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands | |
| DE60121461D1 (de) | Kondensierte pyridoindolderivate | |
| BG100069A (bg) | Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им | |
| ATE123024T1 (de) | 4-aminopyridinderivate. | |
| PT992509E (pt) | Novos derivados macrolidos | |
| ATE311389T1 (de) | Wirkstoffvorläufer von imidazopyridin-derivaten | |
| DK0782567T3 (da) | Isothiourinstofderivater og fremgangsmåder til deres fremstilling | |
| NO995431L (no) | Substituerte 3,3-diamino-2-propennitriler, deres fremstilling og anvendelse | |
| DK0748314T3 (da) | Tetrasubstituerede imidazolderivater, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf | |
| ATE212996T1 (de) | Anthracyclin-derivate | |
| NO991734L (no) | Pyrazolinoner for behandling av potensforstyrrelser |