DK106039C - Fremgangsmåde til fremstilling af quinazolon-derivater eller syreadditionssalte deraf. - Google Patents
Fremgangsmåde til fremstilling af quinazolon-derivater eller syreadditionssalte deraf.Info
- Publication number
- DK106039C DK106039C DK531164AA DK531164A DK106039C DK 106039 C DK106039 C DK 106039C DK 531164A A DK531164A A DK 531164AA DK 531164 A DK531164 A DK 531164A DK 106039 C DK106039 C DK 106039C
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- acid addition
- addition salts
- quinazolone derivatives
- quinazolone
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF39784A DE1231705B (de) | 1963-05-18 | 1963-05-18 | Verfahren zur Herstellung von 2, 3-substituierten Chinazolon-(4)-derivaten |
| DEF0042147 | 1964-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK106039C true DK106039C (da) | 1966-12-12 |
Family
ID=25975761
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK245564AA DK104409C (da) | 1963-05-18 | 1964-05-15 | Fremgangsmåde til fremstilling af quinazolonderivater eller syreadditionssalte deraf. |
| DK531164AA DK106039C (da) | 1963-05-18 | 1964-05-15 | Fremgangsmåde til fremstilling af quinazolon-derivater eller syreadditionssalte deraf. |
| DK531064AA DK105765C (da) | 1963-05-18 | 1964-05-15 | Fremgangsmåde til fremstilling af quinazolon-derivater eller syreadditionssalte deraf. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK245564AA DK104409C (da) | 1963-05-18 | 1964-05-15 | Fremgangsmåde til fremstilling af quinazolonderivater eller syreadditionssalte deraf. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK531064AA DK105765C (da) | 1963-05-18 | 1964-05-15 | Fremgangsmåde til fremstilling af quinazolon-derivater eller syreadditionssalte deraf. |
Country Status (10)
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1003802A (en) * | 1963-06-04 | 1965-09-08 | Searle & Co | Pyrimidinone derivatives |
| GB1062357A (en) * | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
| DE2027645A1 (de) * | 1970-06-05 | 1971-12-09 | Byk Gulden Lomberg Chemische Fa bnk GmbH, 7750 Konstanz | Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel |
| US3900476A (en) * | 1973-05-17 | 1975-08-19 | Upjohn Co | 2(2'-pyrimidylamino)quinazolines and their preparation |
| US3936453A (en) * | 1974-01-28 | 1976-02-03 | Sandoz, Inc. | 1-Substituted-2-disubstituted aminoquin azolin-4(1h)-ones |
| US3959279A (en) * | 1974-01-28 | 1976-05-25 | Sandoz, Inc. | 1-Substituted-2-imino-quinazolin-4(1H)ones |
| US4113637A (en) * | 1974-09-10 | 1978-09-12 | Institut Francais Du Petrole | Alkyl-guanidino-heterocyclic compounds, their manufacture and use as additives for fuels and lubricants |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| AU4858596A (en) * | 1995-09-15 | 1997-04-01 | Torrey Pines Institute For Molecular Studies | Synthesis of quinazolinone libraries |
| US6258819B1 (en) * | 1999-08-05 | 2001-07-10 | Syntex (U.S.A.) Llc | Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones |
| US7671200B2 (en) * | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| DK1939203T3 (en) * | 2000-04-25 | 2015-02-23 | Icos Corp | INHIBITORS OF HUMAN phosphatidyl-inositol 3-kinase DELTA ISOFORM |
| JPWO2002094790A1 (ja) * | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| WO2003039460A2 (en) * | 2001-11-07 | 2003-05-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| AU2002346471A1 (en) * | 2001-11-20 | 2003-06-10 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| CA2475879A1 (en) * | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Synthesis of quinazolinones |
| WO2003094839A2 (en) * | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
| EP1553931A4 (en) * | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| EP1513820A4 (en) * | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| US7041676B2 (en) * | 2002-06-14 | 2006-05-09 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US7211580B2 (en) * | 2002-07-23 | 2007-05-01 | Cytokinetics, Incorporated | Compounds, compositions, and methods |
| JP2005536553A (ja) * | 2002-08-21 | 2005-12-02 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| US7557115B2 (en) * | 2002-09-30 | 2009-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| CA2518465A1 (en) * | 2003-03-25 | 2004-10-14 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US7723344B2 (en) | 2003-08-13 | 2010-05-25 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2005016348A1 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| US20050054614A1 (en) * | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
| EP1699777B1 (en) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| JP2007513058A (ja) * | 2003-09-08 | 2007-05-24 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
| EP1682534A2 (en) * | 2003-11-03 | 2006-07-26 | Cytokinetics, Inc. | Pyrimidin-4-one compounds, compositions, and methods |
| US20050148593A1 (en) * | 2003-11-07 | 2005-07-07 | Gustave Bergnes | Compounds, compositions, and methods |
| WO2005061460A1 (en) * | 2003-12-08 | 2005-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| GEP20094679B (en) | 2004-03-15 | 2009-05-10 | Takeda Pharmaceuticals Co | Dipeptidyl peptidase inhibitors |
| EP3943494A1 (en) | 2004-05-13 | 2022-01-26 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| JP2008500338A (ja) * | 2004-05-25 | 2008-01-10 | イコス・コーポレイション | 造血細胞の異常増殖を治療及び／又は予防する方法 |
| EP2805953B1 (en) | 2004-12-21 | 2016-03-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2006089106A2 (en) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| DE102005024017A1 (de) * | 2005-05-25 | 2006-11-30 | Merck Patent Gmbh | Chinazolinone |
| GEP20135838B (en) | 2005-09-14 | 2013-06-10 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors usage at diabetes treatment |
| WO2007033265A1 (en) * | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetis |
| CA2622642C (en) * | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP2233472B1 (en) * | 2006-03-28 | 2014-01-15 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| WO2007112368A1 (en) * | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| DK2073810T3 (da) * | 2006-09-13 | 2011-10-31 | Takeda Pharmaceutical | Anvendelse af 2-6-(3-aminio-piperidin-l-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-l-ylmethyl-4-fluor-benzonitril til behandling af diabetes, cancer, autoimmune sygdomme og HIV infektion |
| TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| NZ631024A (en) | 2008-11-13 | 2016-04-29 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| MX2011009955A (es) | 2009-03-24 | 2011-11-18 | Gilead Calistoga Llc | Atropisomeros de derivados de 2-purinil-3-tolil-quinazolinona y metodos de uso. |
| ES2548253T3 (es) * | 2009-04-20 | 2015-10-15 | Gilead Calistoga Llc | Métodos para el tratamiento de tumores sólidos |
| EP2456443A1 (en) | 2009-07-21 | 2012-05-30 | Gilead Calistoga LLC | Treatment of liver disorders with pi3k inhibitors |
| EP2697206B1 (en) | 2011-04-10 | 2019-04-03 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| JP2015509537A (ja) | 2012-03-05 | 2015-03-30 | ギリアード カリストガ エルエルシー | （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの多形性形態 |
| CA2934534A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
| NZ720867A (en) | 2013-12-20 | 2018-01-26 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| MX2016016530A (es) | 2014-06-13 | 2017-03-27 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-quinasa. |
-
0
- GB GB1053063D patent/GB1053063A/en active Active
- DE DENDAT1249281D patent/DE1249281B/de active Pending
-
1963
- 1963-05-18 DE DEF39784A patent/DE1231705B/de active Pending
-
1964
- 1964-05-14 CH CH90567A patent/CH447183A/de unknown
- 1964-05-14 CH CH628164A patent/CH447181A/de unknown
- 1964-05-14 US US367568A patent/US3322756A/en not_active Expired - Lifetime
- 1964-05-14 CH CH90467A patent/CH447182A/de unknown
- 1964-05-14 SE SE5933/64A patent/SE314074B/xx unknown
- 1964-05-15 NL NL6405448A patent/NL6405448A/xx unknown
- 1964-05-15 AT AT774565A patent/AT258917B/de active
- 1964-05-15 AT AT427764A patent/AT254193B/de active
- 1964-05-15 DK DK245564AA patent/DK104409C/da active
- 1964-05-15 AT AT774665A patent/AT258918B/de active
- 1964-05-15 DK DK531164AA patent/DK106039C/da active
- 1964-05-15 DK DK531064AA patent/DK105765C/da active
- 1964-05-19 BE BE648093A patent/BE648093A/xx unknown
- 1964-08-17 FR FR985329A patent/FR3806M/fr active Active
-
1965
- 1965-11-23 SE SE1512665A patent/SE314076B/xx unknown
- 1965-11-23 SE SE1512565A patent/SE314075B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT258917B (de) | 1967-12-27 |
| NL6405448A (US20040242566A1-20041202-C00155.png) | 1964-11-19 |
| US3322756A (en) | 1967-05-30 |
| CH447182A (de) | 1967-11-30 |
| AT254193B (de) | 1967-05-10 |
| DK105765C (da) | 1966-11-07 |
| CH447183A (de) | 1967-11-30 |
| SE314075B (US20040242566A1-20041202-C00155.png) | 1969-09-01 |
| CH447181A (de) | 1967-11-30 |
| SE314074B (US20040242566A1-20041202-C00155.png) | 1969-09-01 |
| FR3806M (fr) | 1966-01-03 |
| DE1231705B (de) | 1967-01-05 |
| AT258918B (de) | 1967-12-27 |
| DE1249281B (US20040242566A1-20041202-C00155.png) | |
| GB1053063A (US20040242566A1-20041202-C00155.png) | |
| SE314076B (US20040242566A1-20041202-C00155.png) | 1969-09-01 |
| BE648093A (US20040242566A1-20041202-C00155.png) | 1964-11-19 |
| DK104409C (da) | 1966-05-16 |
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