DK1045691T3 - Kombinationer af statin-carboxylalkylether - Google Patents

Kombinationer af statin-carboxylalkylether

Info

Publication number
DK1045691T3
DK1045691T3 DK98960278T DK98960278T DK1045691T3 DK 1045691 T3 DK1045691 T3 DK 1045691T3 DK 98960278 T DK98960278 T DK 98960278T DK 98960278 T DK98960278 T DK 98960278T DK 1045691 T3 DK1045691 T3 DK 1045691T3
Authority
DK
Denmark
Prior art keywords
statin
combinations
alkyl ether
carboxyl alkyl
carboxyl
Prior art date
Application number
DK98960278T
Other languages
Danish (da)
English (en)
Inventor
Charles Larry Bisgaier
Roger Schofield Newton
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK1045691T3 publication Critical patent/DK1045691T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
DK98960278T 1997-12-12 1998-11-20 Kombinationer af statin-carboxylalkylether DK1045691T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6937597P 1997-12-12 1997-12-12
PCT/US1998/024679 WO1999030704A1 (en) 1997-12-12 1998-11-20 Statin-carboxyalkylether combinations

Publications (1)

Publication Number Publication Date
DK1045691T3 true DK1045691T3 (da) 2005-03-14

Family

ID=22088573

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98960278T DK1045691T3 (da) 1997-12-12 1998-11-20 Kombinationer af statin-carboxylalkylether

Country Status (30)

Country Link
EP (1) EP1045691B1 (de)
JP (1) JP2002508320A (de)
KR (1) KR20010033003A (de)
AR (1) AR017851A1 (de)
AT (1) ATE285762T1 (de)
AU (1) AU754089B2 (de)
BR (1) BR9813542A (de)
CA (1) CA2304612A1 (de)
CO (1) CO4970816A1 (de)
CR (1) CR5926A (de)
CU (1) CU20000140A7 (de)
DE (1) DE69828442T2 (de)
DK (1) DK1045691T3 (de)
ES (1) ES2230733T3 (de)
GT (1) GT199800196A (de)
HN (1) HN1998000185A (de)
HU (1) HUP0004547A3 (de)
IL (1) IL135349A0 (de)
IS (1) IS2150B (de)
MY (1) MY118381A (de)
NO (1) NO20002966D0 (de)
NZ (1) NZ503982A (de)
PA (1) PA8464601A1 (de)
PE (1) PE20000017A1 (de)
PL (1) PL341066A1 (de)
PT (1) PT1045691E (de)
SV (1) SV1998000146A (de)
UY (1) UY25299A1 (de)
WO (1) WO1999030704A1 (de)
ZA (1) ZA9811348B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
US20030105154A1 (en) 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
JP2003524582A (ja) * 1997-12-12 2003-08-19 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 抗高脂血症性スタチン−Ｌｐ（ａ）阻害剤配合物
JP2002525321A (ja) * 1998-09-30 2002-08-13 ワーナー−ランバート・カンパニー カテーテルによる血管再生を予防または遅らせる方法
US6562864B1 (en) * 1999-09-02 2003-05-13 Drake Larson Catechin multimers as therapeutic drug delivery agents
IN191580B (de) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd
GEP20053428B (en) 2000-01-25 2005-01-25 Warner Lambert Co Calcium Dicarboxylate Ethers, Methods of Making Same, and Treatment of Vascular Disease and Diabetes Therewith
AU2001256278A1 (en) * 2000-04-18 2001-10-30 Bayer Aktiengesellschaft Use of cse inhibitors for treating heart failure
NZ521713A (en) * 2000-04-26 2004-09-24 Warner Lambert Co Combination of carboxyalkylethers with antihypertensives and pharmaceutical use
US6689807B1 (en) * 2000-06-08 2004-02-10 Caritas St. Elizabeth's Medical Center Of Boston, Inc. HMG CoA reductase inhibitors for promoting angiogenesis
KR20040026705A (ko) 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
AU2002324715B2 (en) * 2001-08-16 2009-03-12 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
US10028926B2 (en) * 2012-01-06 2018-07-24 Gemphire Therapeutics Inc. Methods of reducing risk of cardiovascular disease
CA3000016A1 (en) * 2015-11-06 2017-05-11 Gemphire Therapeutics Inc. Gemcabene combinations for the treatment of cardiovascular disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases

Also Published As

Publication number Publication date
EP1045691A1 (de) 2000-10-25
PL341066A1 (en) 2001-03-26
PE20000017A1 (es) 2000-01-20
HN1998000185A (es) 1999-06-02
HUP0004547A2 (hu) 2001-05-28
IS2150B (is) 2006-10-13
ZA9811348B (en) 1999-06-14
PT1045691E (pt) 2005-03-31
WO1999030704A1 (en) 1999-06-24
ES2230733T3 (es) 2005-05-01
SV1998000146A (es) 1999-09-30
NO20002966L (no) 2000-06-09
BR9813542A (pt) 2000-10-10
ATE285762T1 (de) 2005-01-15
IS5445A (is) 2000-04-14
AU1591599A (en) 1999-07-05
HUP0004547A3 (en) 2001-12-28
PA8464601A1 (es) 2001-12-14
GT199800196A (es) 2000-06-03
IL135349A0 (en) 2001-05-20
CA2304612A1 (en) 1999-06-24
AR017851A1 (es) 2001-10-24
NO20002966D0 (no) 2000-06-09
CO4970816A1 (es) 2000-11-07
MY118381A (en) 2004-10-30
NZ503982A (en) 2002-03-28
AU754089B2 (en) 2002-11-07
CR5926A (es) 2000-03-06
DE69828442D1 (de) 2005-02-03
DE69828442T2 (de) 2005-06-02
KR20010033003A (ko) 2001-04-25
EP1045691B1 (de) 2004-12-29
CU20000140A7 (es) 2005-10-19
JP2002508320A (ja) 2002-03-19
UY25299A1 (es) 2001-08-27

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