DK1003494T3 - (d)-metadon, et ikke-opioidt analgetikum - Google Patents

(d)-metadon, et ikke-opioidt analgetikum

Info

Publication number
DK1003494T3
DK1003494T3 DK98904609T DK98904609T DK1003494T3 DK 1003494 T3 DK1003494 T3 DK 1003494T3 DK 98904609 T DK98904609 T DK 98904609T DK 98904609 T DK98904609 T DK 98904609T DK 1003494 T3 DK1003494 T3 DK 1003494T3
Authority
DK
Denmark
Prior art keywords
alpha
subject
methadone
normethadol
acetylmethadol
Prior art date
Application number
DK98904609T
Other languages
Danish (da)
English (en)
Inventor
Charles E Inturrisi
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of DK1003494T3 publication Critical patent/DK1003494T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK98904609T 1997-01-22 1998-01-21 (d)-metadon, et ikke-opioidt analgetikum DK1003494T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3530897P 1997-01-22 1997-01-22
PCT/US1998/001088 WO1998031358A1 (en) 1997-01-22 1998-01-21 d-METHADONE, A NONOPIOID ANALGESIC

Publications (1)

Publication Number Publication Date
DK1003494T3 true DK1003494T3 (da) 2007-07-16

Family

ID=21881853

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98904609T DK1003494T3 (da) 1997-01-22 1998-01-21 (d)-metadon, et ikke-opioidt analgetikum

Country Status (12)

Country Link
US (1) US6008258A (pt)
EP (1) EP1003494B1 (pt)
JP (2) JP4514241B2 (pt)
AT (1) ATE357226T1 (pt)
AU (1) AU6244898A (pt)
CA (1) CA2278422C (pt)
DE (1) DE69837387T2 (pt)
DK (1) DK1003494T3 (pt)
ES (1) ES2283049T3 (pt)
MA (1) MA24794A1 (pt)
PT (1) PT1003494E (pt)
WO (1) WO1998031358A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2981099A (en) * 1998-03-09 1999-09-27 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
US20070197651A1 (en) * 1998-03-09 2007-08-23 Tufts University Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
US20060167114A1 (en) * 1998-03-09 2006-07-27 Louis Shuster Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
EP1102589B1 (en) * 1998-07-16 2006-11-02 Memorial Sloan-Kettering Institute For Cancer Research Topical compositions comprising an opioid analgesic and an nmda antagonist
US6897242B1 (en) * 1999-02-24 2005-05-24 Judson J. Somerville Non-racemic mixtures of d- and l- methadone and method of treating pain
AU2001251374A1 (en) * 2000-04-07 2001-10-23 Ultramed International, Inc. Maintaining abstinence after detoxification from opiate addiction
EP1276475A2 (en) 2000-04-28 2003-01-22 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
US7820688B2 (en) 2001-04-27 2010-10-26 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
JP2005518411A (ja) * 2002-01-16 2005-06-23 エンド ファーマシューティカルズ インコーポレーテッド 中枢神経系の障害を治療する製薬組成物及び方法
WO2003061594A2 (en) * 2002-01-23 2003-07-31 The Regents Of The University Of California Methods and compositions for reducing the development of drug tolerance and/or physical dependence
WO2003082215A2 (en) * 2002-03-27 2003-10-09 Memorial Sloan-Kettering Cancer Center Synergistic l-methadone compositions and methods of use thereof
US20060058331A1 (en) * 2002-05-13 2006-03-16 Bradley Galer Abuse resistant opioid dosage form
JP2006500395A (ja) * 2002-09-09 2006-01-05 エンド ファーマシューティカルズ インコーポレーテッド 組み合わされた即時放出及び徐放の鎮痛組成物
US20040180915A1 (en) * 2003-03-14 2004-09-16 Xanodyne Pharmacal, Inc. Methadone-containing compositions for parenteral administration and method of use thereof
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20100010096A1 (en) * 2006-10-27 2010-01-14 John Charin Somberg Methadone chiral isolate as an improved pharmaceutical
WO2008073381A2 (en) * 2006-12-11 2008-06-19 University Of Kentucky Research Foundation Synergistic effects of combinations of nornicotine and opioids for the treatment of pain
US9468611B2 (en) 2012-09-27 2016-10-18 Relmada Therapeutics, Inc. d-Methadone for the treatment of psychiatric symptoms
CN110573159A (zh) * 2017-01-31 2019-12-13 保罗·L·曼佛雷蒂 用于神经系统的障碍的治疗的d-美沙酮及其衍生物
US20180280294A1 (en) * 2017-03-31 2018-10-04 Depco, Inc. Therapeutic putty having analgesics and/or counterirritants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895056A (en) * 1972-12-26 1975-07-15 Lilly Co Eli Alpha-d1-4-acetoxy-1-methyl-3,3-diphenylhexylamine and salts
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
CA2115792C (en) * 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
US5352683A (en) * 1993-03-05 1994-10-04 Virginia Commonwealth University Medical College Of Virginia Method for the treatment of chronic pain

Also Published As

Publication number Publication date
JP2001508797A (ja) 2001-07-03
WO1998031358A1 (en) 1998-07-23
PT1003494E (pt) 2007-06-06
EP1003494B1 (en) 2007-03-21
DE69837387T2 (de) 2007-12-13
ATE357226T1 (de) 2007-04-15
MA24794A1 (fr) 1999-12-31
CA2278422C (en) 2007-11-13
CA2278422A1 (en) 1998-07-23
AU6244898A (en) 1998-08-07
ES2283049T3 (es) 2007-10-16
JP2010013477A (ja) 2010-01-21
EP1003494A1 (en) 2000-05-31
JP4514241B2 (ja) 2010-07-28
DE69837387D1 (de) 2007-05-03
EP1003494A4 (en) 2002-10-16
US6008258A (en) 1999-12-28

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