DK0994875T3 - 3-Pyridyl-1-azabicycloalkanderivater til forhindring og behandling af afvigelser i centralnervesystemet - Google Patents
3-Pyridyl-1-azabicycloalkanderivater til forhindring og behandling af afvigelser i centralnervesystemetInfo
- Publication number
- DK0994875T3 DK0994875T3 DK98918598T DK98918598T DK0994875T3 DK 0994875 T3 DK0994875 T3 DK 0994875T3 DK 98918598 T DK98918598 T DK 98918598T DK 98918598 T DK98918598 T DK 98918598T DK 0994875 T3 DK0994875 T3 DK 0994875T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridyl
- aza
- bicyclo
- nervous system
- central nervous
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- FDAOGGNPGDPKBY-UHFFFAOYSA-N 2-pyridin-3-yl-1-azabicyclo[2.2.1]heptane Chemical class C1CN2CC1CC2C1=CC=CN=C1 FDAOGGNPGDPKBY-UHFFFAOYSA-N 0.000 abstract 1
- WIEWCOLOPGXZDJ-UHFFFAOYSA-N 2-pyridin-3-yl-1-azabicyclo[3.2.2]nonane Chemical compound C1CN2CCC1CCC2C1=CC=CN=C1 WIEWCOLOPGXZDJ-UHFFFAOYSA-N 0.000 abstract 1
- SXRRAFMKMZGQJY-UHFFFAOYSA-N 3-pyridin-3-yl-1-azabicyclo[3.2.2]nonane Chemical compound C1CN(C2)CCC1CC2C1=CC=CN=C1 SXRRAFMKMZGQJY-UHFFFAOYSA-N 0.000 abstract 1
- PHXZTDLBLWHZEJ-UHFFFAOYSA-N 7-pyridin-3-yl-1-azabicyclo[2.2.1]heptane Chemical compound C1CN2CCC1C2C1=CC=CN=C1 PHXZTDLBLWHZEJ-UHFFFAOYSA-N 0.000 abstract 1
- BXZMIGKZXVFLGL-UHFFFAOYSA-N 7-pyridin-3-yl-1-azabicyclo[3.2.2]nonane Chemical compound C1CN2CCCC1CC2C1=CC=CN=C1 BXZMIGKZXVFLGL-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000003957 neurotransmitter release Effects 0.000 abstract 1
- YJYPZLAZNIGNRP-UHFFFAOYSA-N rjr-2429 Chemical compound C1CN2CCC1CC2C1=CC=CN=C1 YJYPZLAZNIGNRP-UHFFFAOYSA-N 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/885,768 US6624173B1 (en) | 1997-06-30 | 1997-06-30 | Pharmaceutical compositions for treating and/or preventing CNS disorders |
| US08/885,397 US6525065B1 (en) | 1997-06-30 | 1997-06-30 | Pharmaceutical compositions and methods for effecting dopamine release |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0994875T3 true DK0994875T3 (da) | 2004-06-21 |
Family
ID=27128761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98918598T DK0994875T3 (da) | 1997-06-30 | 1998-04-22 | 3-Pyridyl-1-azabicycloalkanderivater til forhindring og behandling af afvigelser i centralnervesystemet |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0994875B1 (https=) |
| JP (1) | JP2002511090A (https=) |
| AT (1) | ATE261443T1 (https=) |
| AU (1) | AU7149798A (https=) |
| CA (1) | CA2294990C (https=) |
| DE (1) | DE69822300T2 (https=) |
| DK (1) | DK0994875T3 (https=) |
| ES (1) | ES2214707T3 (https=) |
| PT (1) | PT994875E (https=) |
| WO (1) | WO1999000385A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| FR2791678B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| EP1225955A1 (en) * | 1999-11-01 | 2002-07-31 | Targacept, Inc. | Aryl olefinic azacyclic, and aryl acetylenic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| EP1315493A4 (en) * | 2000-08-21 | 2007-12-05 | Univ Georgetown | 2-3-DISUBSTITUTED QUINUCLIDINS AS MONOAMINE CARRIER MODULATORS AND THERAPEUTIC AND DIAGNOSTIC METHODS BASED THEREON |
| HK1054393B (en) | 2000-09-20 | 2009-08-28 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
| GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
| JP4923630B2 (ja) * | 2006-03-02 | 2012-04-25 | 宇部興産株式会社 | ４−置換テトラヒドロピランの製造方法 |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| JP5413441B2 (ja) * | 2011-12-09 | 2014-02-12 | 宇部興産株式会社 | ４−置換テトラヒドロピランの製造方法 |
| CN104311514B (zh) * | 2014-10-14 | 2016-06-22 | 安徽扬子化工有限公司 | 3-羟甲基四氢呋喃酯的合成方法 |
| CN117624393A (zh) * | 2023-11-24 | 2024-03-01 | 中国科学院烟台海岸带研究所 | 一种吡啶基席夫碱阴离子化菊糖季铵盐及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0412798A3 (en) * | 1989-08-08 | 1992-07-01 | Merck Sharp & Dohme Ltd. | Substituted pyridines, their preparation, formulations and use in dementia |
| US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| AU7474794A (en) * | 1993-07-22 | 1995-02-20 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| US5510355A (en) * | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
| WO1996036637A1 (en) * | 1995-05-17 | 1996-11-21 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
-
1998
- 1998-04-22 EP EP98918598A patent/EP0994875B1/en not_active Expired - Lifetime
- 1998-04-22 ES ES98918598T patent/ES2214707T3/es not_active Expired - Lifetime
- 1998-04-22 DK DK98918598T patent/DK0994875T3/da active
- 1998-04-22 JP JP50551699A patent/JP2002511090A/ja not_active Ceased
- 1998-04-22 DE DE69822300T patent/DE69822300T2/de not_active Expired - Fee Related
- 1998-04-22 PT PT98918598T patent/PT994875E/pt unknown
- 1998-04-22 CA CA002294990A patent/CA2294990C/en not_active Expired - Fee Related
- 1998-04-22 AT AT98918598T patent/ATE261443T1/de not_active IP Right Cessation
- 1998-04-22 AU AU71497/98A patent/AU7149798A/en not_active Abandoned
- 1998-04-22 WO PCT/US1998/008145 patent/WO1999000385A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PT994875E (pt) | 2004-06-30 |
| WO1999000385A1 (en) | 1999-01-07 |
| ES2214707T3 (es) | 2004-09-16 |
| DE69822300T2 (de) | 2005-03-10 |
| CA2294990A1 (en) | 1999-01-07 |
| JP2002511090A (ja) | 2002-04-09 |
| CA2294990C (en) | 2007-03-06 |
| EP0994875A1 (en) | 2000-04-26 |
| ATE261443T1 (de) | 2004-03-15 |
| DE69822300D1 (de) | 2004-04-15 |
| EP0994875B1 (en) | 2004-03-10 |
| AU7149798A (en) | 1999-01-19 |
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