DK0983290T3 - Fremgangsmåde til fremstilling af polymerer, der har nukleobaser som sidegrupper - Google Patents

Fremgangsmåde til fremstilling af polymerer, der har nukleobaser som sidegrupper

Info

Publication number
DK0983290T3
DK0983290T3 DK98928268T DK98928268T DK0983290T3 DK 0983290 T3 DK0983290 T3 DK 0983290T3 DK 98928268 T DK98928268 T DK 98928268T DK 98928268 T DK98928268 T DK 98928268T DK 0983290 T3 DK0983290 T3 DK 0983290T3
Authority
DK
Denmark
Prior art keywords
nucleobases
side groups
preparing polymers
polymers
preparing
Prior art date
Application number
DK98928268T
Other languages
Danish (da)
English (en)
Inventor
Alexander Doemling
Wolfgang Richter
Original Assignee
Morphochem Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19720165A external-priority patent/DE19720165A1/de
Priority claimed from DE19720216A external-priority patent/DE19720216A1/de
Application filed by Morphochem Ag filed Critical Morphochem Ag
Application granted granted Critical
Publication of DK0983290T3 publication Critical patent/DK0983290T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/10—Isocyanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DK98928268T 1997-05-14 1998-05-14 Fremgangsmåde til fremstilling af polymerer, der har nukleobaser som sidegrupper DK0983290T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19720165A DE19720165A1 (de) 1997-05-14 1997-05-14 Verfahren zur Herstellung von Polymeren, die Nucleobasen als Seitengruppen aufweisen
DE19720216A DE19720216A1 (de) 1997-05-14 1997-05-14 Multifunktionelle Isonitrile und Verfahren zu deren Herstellung
PCT/EP1998/002860 WO1998051697A2 (de) 1997-05-14 1998-05-14 Verfahren zur herstellung von polymeren, die nucleobasen als seitengruppen aufweisen

Publications (1)

Publication Number Publication Date
DK0983290T3 true DK0983290T3 (da) 2004-06-14

Family

ID=26036538

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98928268T DK0983290T3 (da) 1997-05-14 1998-05-14 Fremgangsmåde til fremstilling af polymerer, der har nukleobaser som sidegrupper

Country Status (12)

Country Link
US (1) US6355726B1 (cs)
EP (1) EP0983290B1 (cs)
JP (1) JP2002500643A (cs)
AU (1) AU750974B2 (cs)
CA (1) CA2290614C (cs)
CZ (1) CZ299816B6 (cs)
DE (1) DE59810914D1 (cs)
DK (1) DK0983290T3 (cs)
HU (1) HU226867B1 (cs)
IL (1) IL132518A (cs)
NO (1) NO995551L (cs)
WO (1) WO1998051697A2 (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
CN1997401A (zh) * 2004-06-08 2007-07-11 阿尔扎公司 通过四组分的缩合反应来制备大分子共轭物
US7892737B2 (en) * 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
DE102005041570A1 (de) * 2005-09-01 2007-03-22 Celares Gmbh Hoch verzweigte Reagenzien zur Modifaktion von Biopharmazeutika, deren Herstellung und Anwendung
DE102006039615A1 (de) * 2006-08-24 2008-03-13 Leibniz-Institut Für Pflanzenbiochemie Esterelongationsverfahren zum sequenzgesteuerten Aufbau alternierender Peptid-Peptoid-Polymere (Peptid-Peptoid-Polymere)
WO2014058570A1 (en) 2012-09-17 2014-04-17 Alltech Associates, Inc. Chromatography media and devices
US10221216B2 (en) 2013-04-11 2019-03-05 Carnegie Mellon University Template-directed γPNA synthesis process and γPNA targeting compounds
US10370415B2 (en) 2013-04-11 2019-08-06 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
WO2016167284A1 (ja) * 2015-04-16 2016-10-20 学校法人関西大学 抗氷核活性剤
WO2016196906A1 (en) 2015-06-05 2016-12-08 W. R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same
CN109923105A (zh) 2016-09-26 2019-06-21 卡耐基梅隆大学 二价核碱基化合物及其用途
CN114315835B (zh) * 2021-11-30 2023-03-03 华南农业大学 一种6-苯甲基腺嘌呤半抗原、人工抗原、抗体及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2942606A1 (de) * 1979-10-22 1981-04-30 Helmut Dipl.-Chem. Aigner Verfahren zur herstellung von saeureamiden und anwendung des verfahrens
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
CA2167391A1 (en) * 1993-07-16 1995-01-26 Robert W. Armstrong Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
WO1996015143A1 (en) * 1994-11-14 1996-05-23 Chiron Corporation SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH
PT739898E (pt) * 1995-03-13 2002-03-28 Aventis Pharma Gmbh Mono-esteres de acidos fosfonucleicos processo para a sua preparacao e sua utilizacao
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate

Also Published As

Publication number Publication date
WO1998051697A2 (de) 1998-11-19
JP2002500643A (ja) 2002-01-08
EP0983290A1 (de) 2000-03-08
CZ385899A3 (cs) 2000-04-12
HU226867B1 (en) 2009-12-28
IL132518A0 (en) 2001-03-19
US6355726B1 (en) 2002-03-12
IL132518A (en) 2007-05-15
HUP0002730A2 (hu) 2000-12-28
AU750974B2 (en) 2002-08-01
NO995551D0 (no) 1999-11-12
HUP0002730A3 (en) 2003-07-28
AU8017598A (en) 1998-12-08
CA2290614A1 (en) 1998-11-19
CA2290614C (en) 2010-09-21
NO995551L (no) 2000-01-12
CZ299816B6 (cs) 2008-12-03
EP0983290B1 (de) 2004-03-03
DE59810914D1 (de) 2004-04-08
WO1998051697A3 (de) 1999-05-14

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