DK0977737T3 - CRF-antagonistisk quino- og quinazoline - Google Patents
CRF-antagonistisk quino- og quinazolineInfo
- Publication number
- DK0977737T3 DK0977737T3 DK98924134T DK98924134T DK0977737T3 DK 0977737 T3 DK0977737 T3 DK 0977737T3 DK 98924134 T DK98924134 T DK 98924134T DK 98924134 T DK98924134 T DK 98924134T DK 0977737 T3 DK0977737 T3 DK 0977737T3
- Authority
- DK
- Denmark
- Prior art keywords
- quino
- quinazoline
- crf antagonistic
- crf
- antagonistic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4452597P | 1997-04-22 | 1997-04-22 | |
| PCT/EP1998/002267 WO1998047874A1 (fr) | 1997-04-22 | 1998-04-15 | Quino- et quinazolines antagonistes crf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0977737T3 true DK0977737T3 (da) | 2004-01-26 |
Family
ID=21932877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98924134T DK0977737T3 (da) | 1997-04-22 | 1998-04-15 | CRF-antagonistisk quino- og quinazoline |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6482836B1 (fr) |
| EP (1) | EP0977737B1 (fr) |
| JP (1) | JP2002501492A (fr) |
| KR (1) | KR20000069311A (fr) |
| AR (1) | AR012488A1 (fr) |
| AT (1) | ATE250035T1 (fr) |
| AU (1) | AU7644698A (fr) |
| CA (1) | CA2272291C (fr) |
| DE (1) | DE69818248T2 (fr) |
| DK (1) | DK0977737T3 (fr) |
| ES (1) | ES2207834T3 (fr) |
| NZ (1) | NZ335822A (fr) |
| PT (1) | PT977737E (fr) |
| TW (1) | TW593280B (fr) |
| WO (1) | WO1998047874A1 (fr) |
| ZA (1) | ZA983358B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875769B2 (en) * | 1996-05-23 | 2005-04-05 | Pfizer Inc. | Substituted6,6-hetero-bicyclicderivatives |
| DK0977737T3 (da) * | 1997-04-22 | 2004-01-26 | Janssen Pharmaceutica Nv | CRF-antagonistisk quino- og quinazoline |
| NL1010018C2 (nl) * | 1997-09-09 | 1999-03-10 | Duphar Int Res | Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking. |
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| PL354784A1 (en) | 1999-09-30 | 2004-02-23 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
| CO5271670A1 (es) * | 1999-10-29 | 2003-04-30 | Pfizer Prod Inc | Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas |
| AR028782A1 (es) | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
| US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| PL209872B1 (pl) | 2002-03-27 | 2011-10-31 | Glaxo Group Ltd | Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja |
| US20100189797A1 (en) | 2002-06-10 | 2010-07-29 | Julien Mendlewicz | Oral antidepressant formulation |
| EP1521747B1 (fr) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Modulateurs de kinase de type recepteur et procedes d'utilisation |
| PL377847A1 (pl) | 2003-01-14 | 2006-02-20 | Arena Pharmaceuticals Inc. | 1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia |
| EA010023B1 (ru) | 2003-07-14 | 2008-06-30 | Арена Фармасьютикалз, Инк. | Конденсированные арильные и гетероарильные производные в качестве модуляторов метаболизма и для профилактики и лечения расстройств, связанных с нарушением метаболизма |
| RS20060035A (en) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| US20060024661A1 (en) * | 2003-07-30 | 2006-02-02 | The Regents Of The University Of California | Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2 |
| CA2534785A1 (fr) * | 2003-08-12 | 2005-02-17 | Robin Douglas Clark | Derives de la tetrahydroquinazoline en tant qu'antagonistes cfr |
| CA2537812C (fr) | 2003-09-26 | 2013-01-22 | Exelixis, Inc. | Modulateurs de c-met et procede d'utilisation |
| US20080009518A1 (en) * | 2004-12-03 | 2008-01-10 | Jaime Bunda | 5-Phenyl-5,6,7,8-Hydroquinoline Tachykinin Receptor Antagonists |
| US20080039494A1 (en) * | 2004-12-03 | 2008-02-14 | Jianming Bao | 8-Phenyl-5,6,7,8-Hydroquinoline Tachykinin Receptor Antagonists |
| CN101784533B (zh) * | 2007-08-22 | 2013-08-21 | 艾博特股份有限两合公司 | 4-苄基氨基喹啉、含有它们的药物组合物和它们在治疗中的用途 |
| WO2009074607A1 (fr) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Associations contenant de la 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (fr) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Procédés de préparation de dérivés de pyrazole utiles comme modulateurs du récepteur de la sérotonine 5-ht<sb>2a</sb> |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CA2995880C (fr) | 2009-01-16 | 2021-01-05 | Exelixis, Inc. | Procedes de preparation de n-(4-{[6,7-bis(methyloxy)quinolein-4-yl]oxy}phenyl)(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
| EP3096756B1 (fr) | 2014-01-21 | 2024-06-12 | Neurocrine Biosciences, Inc. | Antagonistes du récepteur crf1 pour le traitement de l'hyperplasie adrénale congénitale |
| AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| CN109562085A (zh) | 2015-06-12 | 2019-04-02 | 阿速万科学有限责任公司 | 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物 |
| SI3310760T1 (sl) | 2015-06-22 | 2023-02-28 | Arena Pharmaceuticals, Inc. | Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1 |
| AU2016291673A1 (en) | 2015-07-15 | 2018-01-25 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5110347A (en) * | 1990-11-26 | 1992-05-05 | E. I Du Pont De Nemours And Company | Substituted fused heterocyclic herbicides |
| TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| ATE182148T1 (de) * | 1995-05-12 | 1999-07-15 | Neurogen Corp | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
| WO1998029397A1 (fr) | 1996-12-27 | 1998-07-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes pyrimidine a anneaux condenses et leur utilisation medicinale |
| DK0977737T3 (da) * | 1997-04-22 | 2004-01-26 | Janssen Pharmaceutica Nv | CRF-antagonistisk quino- og quinazoline |
| NL1010018C2 (nl) * | 1997-09-09 | 1999-03-10 | Duphar Int Res | Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking. |
-
1998
- 1998-04-15 DK DK98924134T patent/DK0977737T3/da active
- 1998-04-15 CA CA002272291A patent/CA2272291C/fr not_active Expired - Fee Related
- 1998-04-15 EP EP98924134A patent/EP0977737B1/fr not_active Expired - Lifetime
- 1998-04-15 DE DE69818248T patent/DE69818248T2/de not_active Expired - Fee Related
- 1998-04-15 JP JP54498998A patent/JP2002501492A/ja not_active Ceased
- 1998-04-15 NZ NZ335822A patent/NZ335822A/en not_active IP Right Cessation
- 1998-04-15 AU AU76446/98A patent/AU7644698A/en not_active Abandoned
- 1998-04-15 WO PCT/EP1998/002267 patent/WO1998047874A1/fr not_active Application Discontinuation
- 1998-04-15 KR KR1019997004991A patent/KR20000069311A/ko not_active Application Discontinuation
- 1998-04-15 US US09/403,393 patent/US6482836B1/en not_active Expired - Fee Related
- 1998-04-15 AT AT98924134T patent/ATE250035T1/de not_active IP Right Cessation
- 1998-04-15 ES ES98924134T patent/ES2207834T3/es not_active Expired - Lifetime
- 1998-04-15 PT PT98924134T patent/PT977737E/pt unknown
- 1998-04-20 TW TW087105979A patent/TW593280B/zh not_active IP Right Cessation
- 1998-04-21 ZA ZA9803358A patent/ZA983358B/xx unknown
- 1998-04-21 AR ARP980101843A patent/AR012488A1/es not_active Application Discontinuation
-
2002
- 2002-10-08 US US10/266,662 patent/US6610678B2/en not_active Expired - Lifetime
-
2003
- 2003-08-26 US US10/648,843 patent/US20040121998A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818248D1 (de) | 2003-10-23 |
| CA2272291A1 (fr) | 1998-10-29 |
| US20040121998A1 (en) | 2004-06-24 |
| CA2272291C (fr) | 2008-06-17 |
| ATE250035T1 (de) | 2003-10-15 |
| EP0977737B1 (fr) | 2003-09-17 |
| ES2207834T3 (es) | 2004-06-01 |
| WO1998047874A1 (fr) | 1998-10-29 |
| US6482836B1 (en) | 2002-11-19 |
| US20030119818A1 (en) | 2003-06-26 |
| EP0977737A1 (fr) | 2000-02-09 |
| JP2002501492A (ja) | 2002-01-15 |
| TW593280B (en) | 2004-06-21 |
| ZA983358B (en) | 1999-10-21 |
| US6610678B2 (en) | 2003-08-26 |
| KR20000069311A (ko) | 2000-11-25 |
| DE69818248T2 (de) | 2004-06-17 |
| PT977737E (pt) | 2004-02-27 |
| AR012488A1 (es) | 2000-10-18 |
| NZ335822A (en) | 2001-05-25 |
| AU7644698A (en) | 1998-11-13 |
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