DK0977562T3 - Fremgangsmåder og sammensætninger til indgivelse af taxaner - Google Patents
Fremgangsmåder og sammensætninger til indgivelse af taxanerInfo
- Publication number
- DK0977562T3 DK0977562T3 DK99909941T DK99909941T DK0977562T3 DK 0977562 T3 DK0977562 T3 DK 0977562T3 DK 99909941 T DK99909941 T DK 99909941T DK 99909941 T DK99909941 T DK 99909941T DK 0977562 T3 DK0977562 T3 DK 0977562T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- taxanes
- methods
- administration
- taxol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7745998P | 1998-03-10 | 1998-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0977562T3 true DK0977562T3 (da) | 2006-05-01 |
Family
ID=22138176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99909941T DK0977562T3 (da) | 1998-03-10 | 1999-03-10 | Fremgangsmåder og sammensætninger til indgivelse af taxaner |
Country Status (17)
Country | Link |
---|---|
US (1) | US20010029264A1 (ja) |
EP (1) | EP0977562B8 (ja) |
JP (1) | JP2001524988A (ja) |
KR (1) | KR20010012363A (ja) |
CN (1) | CN1255852A (ja) |
AT (1) | ATE314844T1 (ja) |
AU (1) | AU762926B2 (ja) |
BR (1) | BR9904856A (ja) |
CA (1) | CA2288240A1 (ja) |
CY (1) | CY1105690T1 (ja) |
DE (1) | DE69929313T2 (ja) |
DK (1) | DK0977562T3 (ja) |
ES (1) | ES2257038T3 (ja) |
IL (1) | IL131217A0 (ja) |
PT (1) | PT977562E (ja) |
WO (1) | WO1999045918A1 (ja) |
ZA (1) | ZA991885B (ja) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
US6040330A (en) * | 1999-01-08 | 2000-03-21 | Bionumerik Pharmaceuticals, Inc. | Pharmaceutical formulations of taxanes |
EP1479382A1 (en) * | 1999-06-18 | 2004-11-24 | IVAX Research, Inc. | Oral pharmaceutical compositions containing taxanes and methods for treatment employing the same |
US6828346B2 (en) * | 1999-10-25 | 2004-12-07 | Supergen, Inc. | Methods for administration of paclitaxel |
US6136846A (en) | 1999-10-25 | 2000-10-24 | Supergen, Inc. | Formulation for paclitaxel |
EP1251858B1 (en) * | 2000-01-20 | 2005-06-08 | Supratek Pharma Inc. | Podophyllotoxin compositions |
US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
AU2002239282A1 (en) * | 2000-11-28 | 2002-06-11 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
JP2004520398A (ja) * | 2001-01-18 | 2004-07-08 | ファルマシア・アンド・アップジョン・カンパニー | 経口生物学的利用能が改善されたパクリタキセルの化学療法マイクロエマルジョン組成物 |
US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
AU2002351169B2 (en) * | 2001-11-26 | 2007-09-20 | Intas Pharmaceuticals Limited | Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions |
US20040092428A1 (en) * | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
PL374283A1 (en) * | 2001-12-20 | 2005-10-03 | Bristol-Myers Squibb Company | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
WO2003074027A2 (en) * | 2002-03-01 | 2003-09-12 | Novagali Pharma Sa | Self emulsifying drug delivery systems for poorly soluble drugs |
EP1340497A1 (en) * | 2002-03-01 | 2003-09-03 | Novagali Sas | Self emulsifying drug delivery systems for poorly soluble drugs |
CA2493878C (en) * | 2002-07-30 | 2013-07-23 | Wyeth | Parenteral formulations containing a rapamycin hydroxyester |
DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
AU2002350719A1 (en) * | 2002-11-29 | 2004-06-23 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
US20040127551A1 (en) * | 2002-12-27 | 2004-07-01 | Kai Zhang | Taxane-based compositions and methods of use |
EP2181704B1 (en) * | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
WO2004091506A2 (en) * | 2003-04-10 | 2004-10-28 | Ivax Research, Inc. | Taxane-based compositions and methods of use |
EP1498120A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid formulations for the oral administration of taxoids |
EP1510206A1 (en) * | 2003-08-29 | 2005-03-02 | Novagali Pharma SA | Self-nanoemulsifying oily formulation for the administration of poorly water-soluble drugs |
EP1713442A1 (en) * | 2004-01-30 | 2006-10-25 | Pfizer Italia S.r.l. | Semisolid matrix pharmaceutical formulations |
WO2005074889A1 (en) * | 2004-02-03 | 2005-08-18 | Dinesh Shantilal Patel | Novel compositions of taxol derivatives and the process for the manufacture thereof |
US8003122B2 (en) | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
US7989490B2 (en) | 2004-06-02 | 2011-08-02 | Cordis Corporation | Injectable formulations of taxanes for cad treatment |
US7345093B2 (en) | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
US7659310B2 (en) | 2004-04-27 | 2010-02-09 | Formatech, Inc. | Methods of enhancing solubility of agents |
JP2008514714A (ja) * | 2004-09-30 | 2008-05-08 | イーストマン ケミカル カンパニー | 有意な流出阻害を示さない、親油性薬物を可溶化するビタミンetpgs分子を含む医薬製剤及びこのような医薬製剤の使用 |
US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
WO2009120933A2 (en) * | 2008-03-28 | 2009-10-01 | Particle Sciences, Inc. | Pharmaceutical solutions and method for solubilizing therapeutic agents |
US8409601B2 (en) | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
CN102000052B (zh) * | 2008-06-25 | 2012-12-12 | 重庆市中药研究院 | 紫杉醇及其衍生物在制药中的应用 |
WO2011038073A1 (en) | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes comprising docetaxel |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
US20120065255A1 (en) * | 2009-10-19 | 2012-03-15 | Nagesh Palepu | Cabazitaxel formulations and methods of preparing thereof |
SG185389A1 (en) | 2010-05-03 | 2012-12-28 | Teikoku Pharma Usa Inc | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
MX2013007959A (es) * | 2011-01-10 | 2013-12-06 | Celgene Corp | Formas farmaceuticas orales de amida {2-[(1s)-1-(3-etoxi-4-metoxi- fenil]-2-metansulfonil-etil]-3-oxo-2,,3-dihidro-1h-isoindol -4-il}-del acido ciclopropancarboxilico. |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
US10751319B2 (en) | 2015-06-04 | 2020-08-25 | Crititech, Inc. | Collection device and methods for use |
RU2018113280A (ru) | 2015-09-16 | 2019-10-16 | ДиЭфБи СОРИА, ЭлЭлСи | Доставка наночастиц лекарственного средства и способы их использования |
PT3439635T (pt) | 2016-04-04 | 2021-02-11 | Crititech Inc | Formulações para tratamento de tumores sólidos |
JP2020514359A (ja) | 2017-03-15 | 2020-05-21 | ディーエフビー ソリア リミテッド ライアビリティ カンパニー | タキサンのナノ粒子を用いる皮膚悪性腫瘍処置のための局所療法 |
EP3615145B1 (en) | 2017-06-09 | 2024-05-15 | Crititech, Inc. | Compositions for use in the treatment of epithelial cysts by intracystic injection of antineoplastic particles |
JP6840869B2 (ja) | 2017-06-14 | 2021-03-10 | クリチテック,インコーポレイテッド | 肺障害の治療方法 |
CN118649239A (zh) | 2017-10-03 | 2024-09-17 | 克里蒂泰克公司 | 局部递送抗肿瘤颗粒与全身递送免疫治疗剂相结合用于治疗癌症 |
WO2019178024A1 (en) | 2018-03-16 | 2019-09-19 | Dfb Soria, Llc | Topical therapy for the treatment of cervical intraepithelial neoplasia (cin) and cervical cancer using nanoparticles of taxanes |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4228162A (en) * | 1979-07-09 | 1980-10-14 | Research Corporation | Dimethyl isosorbide in liquid formulation of aspirin |
US4578391A (en) * | 1982-01-20 | 1986-03-25 | Yamanouchi Pharmaceutical Co., Ltd. | Oily compositions of antitumor drugs |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
CA2149150C (en) * | 1992-11-27 | 2000-08-01 | David R. Carver | Injectable taxol composition with improved stability |
ES2148345T3 (es) * | 1993-10-22 | 2000-10-16 | Hexal Ag | Composicion farmaceutica con ciclosporina a, un derivado de vitamina e y un emulsionante. |
US5877205A (en) * | 1996-06-28 | 1999-03-02 | Board Of Regents, The University Of Texas System | Parenteral paclitaxel in a stable non-toxic formulation |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
-
1998
- 1998-03-10 IL IL13121798A patent/IL131217A0/xx unknown
-
1999
- 1999-03-09 ZA ZA9901885A patent/ZA991885B/xx unknown
- 1999-03-10 DE DE69929313T patent/DE69929313T2/de not_active Expired - Fee Related
- 1999-03-10 ES ES99909941T patent/ES2257038T3/es not_active Expired - Lifetime
- 1999-03-10 PT PT99909941T patent/PT977562E/pt unknown
- 1999-03-10 DK DK99909941T patent/DK0977562T3/da active
- 1999-03-10 AT AT99909941T patent/ATE314844T1/de not_active IP Right Cessation
- 1999-03-10 JP JP54602599A patent/JP2001524988A/ja not_active Ceased
- 1999-03-10 KR KR19997010315A patent/KR20010012363A/ko not_active Application Discontinuation
- 1999-03-10 WO PCT/US1999/005151 patent/WO1999045918A1/en active IP Right Grant
- 1999-03-10 EP EP99909941A patent/EP0977562B8/en not_active Expired - Lifetime
- 1999-03-10 AU AU29022/99A patent/AU762926B2/en not_active Ceased
- 1999-03-10 CA CA002288240A patent/CA2288240A1/en not_active Abandoned
- 1999-03-10 CN CN99800022A patent/CN1255852A/zh active Pending
- 1999-03-10 BR BR9904856-6A patent/BR9904856A/pt not_active Application Discontinuation
-
2001
- 2001-02-28 US US09/795,626 patent/US20010029264A1/en not_active Abandoned
-
2006
- 2006-03-29 CY CY20061100438T patent/CY1105690T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69929313T2 (de) | 2006-08-17 |
EP0977562B8 (en) | 2006-04-26 |
KR20010012363A (ko) | 2001-02-15 |
ATE314844T1 (de) | 2006-02-15 |
EP0977562B1 (en) | 2006-01-04 |
CA2288240A1 (en) | 1999-09-16 |
BR9904856A (pt) | 2000-07-18 |
MX9910340A (en) | 2000-04-01 |
WO1999045918A1 (en) | 1999-09-16 |
CN1255852A (zh) | 2000-06-07 |
PT977562E (pt) | 2006-05-31 |
IL131217A0 (en) | 2001-01-28 |
AU762926B2 (en) | 2003-07-10 |
CY1105690T1 (el) | 2010-12-22 |
DE69929313D1 (de) | 2006-03-30 |
US20010029264A1 (en) | 2001-10-11 |
EP0977562A1 (en) | 2000-02-09 |
JP2001524988A (ja) | 2001-12-04 |
ES2257038T3 (es) | 2006-07-16 |
ZA991885B (en) | 1999-09-10 |
AU2902299A (en) | 1999-09-27 |
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