DK0975775T3 - Regulatorisk system til inducerbar ekspression af gener med lambdapromotorer - Google Patents

Regulatorisk system til inducerbar ekspression af gener med lambdapromotorer

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Publication number
DK0975775T3
DK0975775T3 DK98924212T DK98924212T DK0975775T3 DK 0975775 T3 DK0975775 T3 DK 0975775T3 DK 98924212 T DK98924212 T DK 98924212T DK 98924212 T DK98924212 T DK 98924212T DK 0975775 T3 DK0975775 T3 DK 0975775T3
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DK
Denmark
Prior art keywords
antirepressor
promoter
gene coding
genes
gene
Prior art date
Application number
DK98924212T
Other languages
Danish (da)
English (en)
Inventor
Nico Maurice Mertens
Erik Rene Remaut
Walter Charles Fiers
Original Assignee
Vlaams Interuniv Inst Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech filed Critical Vlaams Interuniv Inst Biotech
Application granted granted Critical
Publication of DK0975775T3 publication Critical patent/DK0975775T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/73Expression systems using phage (lambda) regulatory sequences
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10311Siphoviridae
    • C12N2795/10322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Mushroom Cultivation (AREA)
DK98924212T 1997-04-23 1998-04-23 Regulatorisk system til inducerbar ekspression af gener med lambdapromotorer DK0975775T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1005884 1997-04-23
PCT/EP1998/002465 WO1998048025A2 (en) 1997-04-23 1998-04-23 Regulatory system for inducible expression of genes with lambdoid promoters

Publications (1)

Publication Number Publication Date
DK0975775T3 true DK0975775T3 (da) 2004-07-26

Family

ID=19764839

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98924212T DK0975775T3 (da) 1997-04-23 1998-04-23 Regulatorisk system til inducerbar ekspression af gener med lambdapromotorer

Country Status (10)

Country Link
US (1) US6485934B1 (de)
EP (1) EP0975775B1 (de)
JP (1) JP2001526533A (de)
AT (1) ATE262041T1 (de)
AU (1) AU729712B2 (de)
CA (1) CA2287541C (de)
DE (1) DE69822453T2 (de)
DK (1) DK0975775T3 (de)
PT (1) PT975775E (de)
WO (1) WO1998048025A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1597369T3 (da) * 2003-02-21 2008-02-04 Biotecnol Sa Anvendelse af caspaseenzymer til modning af manipulerede rekombinante polypeptidfusioner
CN101680014B (zh) 2007-04-03 2018-09-28 奥克西雷恩英国有限公司 分子的糖基化
CN102712914A (zh) 2009-09-29 2012-10-03 根特大学 水解甘露糖-1-磷酸-6-甘露糖连接为磷酸-6-甘露糖
JP2013511272A (ja) 2009-11-19 2013-04-04 オキシレイン ユーケー リミテッド 哺乳類様複合n−グリカンを生成する酵母株
US9689015B2 (en) 2010-09-29 2017-06-27 Oxyrane Uk Limited De-mannosylation of phosphorylated N-glycans
EP2622088A2 (de) 2010-09-29 2013-08-07 Oxyrane UK Limited Mannosidasen zum entkappen von mannose-1-phospho-6-mannose-bindungen und demannosylierung von phosphorylierten n-glykanen sowie verfahren zur ermöglichung der zellulären aufnahme von glykoproteinen durch säugerzellen
WO2012170433A1 (en) * 2011-06-08 2012-12-13 Sutro Biopharma, Inc. Multiple rna polymerase terminator cassettes for efficient transcription of discrete rna templates
CN104379162B (zh) 2012-03-15 2017-03-15 奥克西雷恩英国有限公司 用于治疗蓬佩氏病的方法和材料
CN112521472B (zh) * 2020-12-04 2023-02-07 海南波莲水稻基因科技有限公司 一种与水稻育性及花器官数目相关的分子标记及其应用
GB202205833D0 (en) * 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3319242A1 (de) * 1983-05-27 1984-11-29 Battelle-Institut E.V., 6000 Frankfurt Verfahren und plasmid zur steuerung der expression von klonierten genen
US5571786A (en) * 1990-08-16 1996-11-05 Immuno Aktiengesellschaft Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation
US5416008A (en) * 1991-10-01 1995-05-16 California Institute Of Technology Cross-regulation of gene expression in recombinant cells

Also Published As

Publication number Publication date
PT975775E (pt) 2004-07-30
JP2001526533A (ja) 2001-12-18
EP0975775A2 (de) 2000-02-02
WO1998048025A2 (en) 1998-10-29
CA2287541A1 (en) 1998-10-29
CA2287541C (en) 2010-04-20
AU7649198A (en) 1998-11-13
WO1998048025A3 (en) 1999-01-21
DE69822453T2 (de) 2005-03-24
AU729712B2 (en) 2001-02-08
DE69822453D1 (de) 2004-04-22
EP0975775B1 (de) 2004-03-17
ATE262041T1 (de) 2004-04-15
US6485934B1 (en) 2002-11-26

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