DK0975761T3 - Humant, rekombinant beta-interferon med forbedret opløselighed - Google Patents

Humant, rekombinant beta-interferon med forbedret opløselighed

Info

Publication number
DK0975761T3
DK0975761T3 DK98920533T DK98920533T DK0975761T3 DK 0975761 T3 DK0975761 T3 DK 0975761T3 DK 98920533 T DK98920533 T DK 98920533T DK 98920533 T DK98920533 T DK 98920533T DK 0975761 T3 DK0975761 T3 DK 0975761T3
Authority
DK
Denmark
Prior art keywords
phe
leu
interferon
human
improved solubility
Prior art date
Application number
DK98920533T
Other languages
English (en)
Inventor
Christian Schneider-Fresenius
Bernd Otto
Gero Waschuetza
Original Assignee
Fraunhofer Ges Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung
Application granted granted Critical
Publication of DK0975761T3 publication Critical patent/DK0975761T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
DK98920533T 1997-04-23 1998-04-16 Humant, rekombinant beta-interferon med forbedret opløselighed DK0975761T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19717864A DE19717864C2 (de) 1997-04-23 1997-04-23 Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung
PCT/EP1998/002238 WO1998048018A1 (de) 1997-04-23 1998-04-16 HUMANES, REKOMBINANTES INTERFERON-β MIT VERBESSERTER LÖSLICHKEIT

Publications (1)

Publication Number Publication Date
DK0975761T3 true DK0975761T3 (da) 2004-02-16

Family

ID=7827959

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98920533T DK0975761T3 (da) 1997-04-23 1998-04-16 Humant, rekombinant beta-interferon med forbedret opløselighed

Country Status (10)

Country Link
US (3) US6572853B1 (da)
EP (1) EP0975761B1 (da)
JP (1) JP4189035B2 (da)
AT (1) ATE257859T1 (da)
CA (1) CA2287521C (da)
DE (2) DE19717864C2 (da)
DK (1) DK0975761T3 (da)
ES (1) ES2214709T3 (da)
PT (1) PT975761E (da)
WO (1) WO1998048018A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19717864C2 (de) * 1997-04-23 2001-05-17 Fraunhofer Ges Forschung Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
NZ502375A (en) 1997-07-14 2001-11-30 Bolder Biotechnology Inc The addition of non-natural cysteine derivatives to cause the protein to act as antagonists of the GH family
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
YU48703A (sh) 2001-02-27 2006-05-25 Maxygen Aps Novi interferonu beta-slični molekuli
AU2003254641A1 (en) * 2002-08-28 2004-03-19 Maxygen Aps Interferon beta-like molecules for treatment of cancer
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US20040137581A1 (en) * 2002-10-01 2004-07-15 Xencor Interferon variants with improved properties
WO2005003157A2 (en) * 2003-06-10 2005-01-13 Xencor, Inc. Interferon variants with improved properties
AU2005211362B2 (en) 2004-02-02 2008-03-13 Ambrx, Inc. Modified human interferon polypeptides and their uses
KR100781666B1 (ko) 2004-11-02 2007-12-03 신영기 인간 인터페론-베타 변이체
WO2007110231A2 (en) * 2006-03-28 2007-10-04 Nautilus Biotech, S.A. MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
EP2395099A3 (en) * 2006-05-02 2012-05-16 Allozyne, Inc. Amino acid substituted molecules
WO2008137471A2 (en) 2007-05-02 2008-11-13 Ambrx, Inc. Modified interferon beta polypeptides and their uses
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses
DE102008051574A1 (de) 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten
EP2431051A1 (en) * 2010-09-15 2012-03-21 Vakzine Projekt Management GmbH Type-1 interferons for the treatment of multiple sclerosis
SG10201602076QA (en) 2011-10-01 2016-04-28 Glytech Inc Glycosylated polypeptide and pharmaceutical composition containing same
CN104334574B (zh) 2013-03-29 2020-01-14 株式会社糖锁工学研究所 附加唾液酸化糖链的多肽

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
GB8412564D0 (en) 1984-05-17 1984-06-20 Searle & Co Structure and properties
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
DE19717864C2 (de) * 1997-04-23 2001-05-17 Fraunhofer Ges Forschung Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung

Also Published As

Publication number Publication date
DE19717864A1 (de) 1998-10-29
US20060093579A1 (en) 2006-05-04
JP2001523957A (ja) 2001-11-27
EP0975761B1 (de) 2004-01-14
EP0975761A1 (de) 2000-02-02
CA2287521A1 (en) 1998-10-29
DE19717864C2 (de) 2001-05-17
US7052687B2 (en) 2006-05-30
US6572853B1 (en) 2003-06-03
WO1998048018A1 (de) 1998-10-29
JP4189035B2 (ja) 2008-12-03
PT975761E (pt) 2004-05-31
DE59810596D1 (de) 2004-02-19
ES2214709T3 (es) 2004-09-16
CA2287521C (en) 2009-08-11
US7575894B2 (en) 2009-08-18
US20040022763A1 (en) 2004-02-05
ATE257859T1 (de) 2004-01-15

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