DK0975602T3 - Imidazol- og imidazolinderivater samt anvendelse heraf - Google Patents
Imidazol- og imidazolinderivater samt anvendelse herafInfo
- Publication number
- DK0975602T3 DK0975602T3 DK98915550T DK98915550T DK0975602T3 DK 0975602 T3 DK0975602 T3 DK 0975602T3 DK 98915550 T DK98915550 T DK 98915550T DK 98915550 T DK98915550 T DK 98915550T DK 0975602 T3 DK0975602 T3 DK 0975602T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazoline derivatives
- imidazole
- compounds
- receptors
- alpha2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epoxy Resins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/834,658 US5866579A (en) | 1997-04-11 | 1997-04-11 | Imidazole and imidazoline derivatives and uses thereof |
EP98915550A EP0975602B1 (fr) | 1997-04-11 | 1998-04-10 | Derives d'imidazole et d'imidazoline et leurs utilisations |
PCT/US1998/007453 WO1998046572A1 (fr) | 1997-04-11 | 1998-04-10 | Derives d'imidazole et d'imidazoline et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0975602T3 true DK0975602T3 (da) | 2005-10-17 |
Family
ID=25267478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98915550T DK0975602T3 (da) | 1997-04-11 | 1998-04-10 | Imidazol- og imidazolinderivater samt anvendelse heraf |
Country Status (11)
Country | Link |
---|---|
US (4) | US5866579A (fr) |
EP (1) | EP0975602B1 (fr) |
AT (1) | ATE297899T1 (fr) |
AU (1) | AU6970598A (fr) |
DE (1) | DE69830576T2 (fr) |
DK (1) | DK0975602T3 (fr) |
ES (1) | ES2245029T3 (fr) |
HK (1) | HK1026892A1 (fr) |
PT (1) | PT975602E (fr) |
SI (1) | SI0975602T1 (fr) |
WO (1) | WO1998046572A1 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
EP1767525A1 (fr) * | 2001-04-09 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Composés guanidino comme agonistes du récepteur 4 de la mélanocortine (MC4-R) |
FR2846328B1 (fr) * | 2002-10-23 | 2004-12-10 | Servier Lab | Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
EP1562786A2 (fr) * | 2002-11-20 | 2005-08-17 | Johnson Controls Technology Company | Ensemble de miroir de courtoisie illumine et couvert |
US20050059664A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Novel methods for identifying improved, non-sedating alpha-2 agonists |
US20060293359A1 (en) * | 2003-06-25 | 2006-12-28 | Allergan, Inc. | Methods and compositions for the treatment of diabetes |
US7348434B2 (en) | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
FR2858619B1 (fr) * | 2003-08-08 | 2006-12-22 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
EP1843766A1 (fr) * | 2005-01-28 | 2007-10-17 | Merck & Co., Inc. | Composes bicycliques antidiabetiques |
ATE517883T1 (de) * | 2005-08-25 | 2011-08-15 | Schering Corp | Imidazolderivate als funktionelle selektive agonisten des alpha2c-adrenorezeptors |
AU2007213887A1 (en) * | 2006-01-27 | 2007-08-16 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of CNS disorders |
AU2007312390B2 (en) * | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
CA2665255A1 (fr) * | 2006-10-19 | 2008-04-24 | F. Hoffmann-La Roche Ag | Aminomethyl- 2 -imidazoles a affinite avec les recepteurs associes a une amine a l'etat de trace |
JP5064511B2 (ja) | 2006-11-02 | 2012-10-31 | エフ.ホフマン−ラ ロシュ アーゲー | 痕跡アミン関連受容体調節剤としての置換2−イミダゾール |
RU2456281C2 (ru) * | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
ATE509628T1 (de) * | 2006-12-13 | 2011-06-15 | Hoffmann La Roche | Neue 2-imidazole als liganden für trace amine associated receptors (taar) |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
WO2008086131A1 (fr) | 2007-01-12 | 2008-07-17 | Allergan, Inc. | Naphtylméthylimidizoles en tant qu'agents thérapeutiques |
WO2008088937A1 (fr) * | 2007-01-12 | 2008-07-24 | Allergan, Inc. | Quinoléinylméthylimidizoles en tant qu'agents thérapeutiques |
US7868020B2 (en) | 2007-01-12 | 2011-01-11 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
BRPI0806940A2 (pt) * | 2007-02-02 | 2014-05-06 | Hoffmann La Roche | 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc |
MX2009008465A (es) * | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
AU2008270445A1 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (TAARs) |
MX2009013745A (es) * | 2007-07-03 | 2010-01-26 | Hoffmann La Roche | 4-imidazolinas y su uso como antidepresivos. |
CN101765587A (zh) * | 2007-07-27 | 2010-06-30 | 弗·哈夫曼-拉罗切有限公司 | 作为taar配体的2-氮杂环丁烷甲胺类和2-吡咯烷甲胺类 |
EP2182935A1 (fr) * | 2007-08-02 | 2010-05-12 | F. Hoffmann-Roche AG | Utilisation de dérivés de benzamide pour le traitement de troubles du snc |
CA2695331A1 (fr) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Derives de pyridinecarboxamide et de benzamide servant de ligands de taar1 |
RU2491284C2 (ru) * | 2007-08-15 | 2013-08-27 | Аллерган, Инк. | Адренергические соединения |
AU2009246601A1 (en) * | 2008-05-13 | 2009-11-19 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
BRPI0916363A2 (pt) * | 2008-07-24 | 2018-05-29 | Hoffmann La Roche | derivados de 4,5-di-hidro-oxazol-2-ila |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US20110306635A1 (en) * | 2009-02-06 | 2011-12-15 | Allergan ,Inc. | Pyridine compounds as subtype selective modulators of alpha2b and /or alpha 2c adrenergic receptors |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
CA2843245A1 (fr) | 2011-07-25 | 2013-01-31 | Allergan, Inc. | Derives de n-(imidazolidin-2-ylidene)heterocyclopenta[b]pyridine utilises comme modulateurs des recepteurs adrenergiques alpha-2 |
US9611224B2 (en) | 2012-07-13 | 2017-04-04 | Hoffmann-La Roche Inc. | Antiproliferative benzo [B] azepin-2-ones |
BR112018015389B1 (pt) | 2016-03-17 | 2023-12-19 | F. Hoffmann-La Roche Ag | Derivado de 5-etil-4-metil-pirazol-3-carboxamida, seu processo de fabricação, preparação farmacêutica oral e uso |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3288805A (en) * | 1966-11-29 | Amino-eviid azoline | ||
US3636219A (en) * | 1964-03-02 | 1972-01-18 | Du Pont | Anticholinergic compositions containing certain thiazolines or imidazolines |
CH632268A5 (de) * | 1977-01-14 | 1982-09-30 | Sandoz Ag | Verfahren zur herstellung von neuen heterocyclylaminoderivaten. |
NL7711390A (nl) * | 1977-10-18 | 1979-04-20 | Philips Nv | Nieuwe 2-arylimino-hexahydopyrimidinen en - imi- dazolidinen, zouten en complexen daarvan, werk- wijze ter bereiding van de nieuwe verbindingen, alsmede fungicide preparaten op basis van de nieuwe verbindingen. |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
CA2104873C (fr) * | 1991-02-26 | 2000-05-23 | James N. Campbell | Compositions et methodes pour le traitement de la douleur entretenue par le systeme sympathique |
US5663189A (en) * | 1993-07-01 | 1997-09-02 | The Procter & Gamble Company | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists |
US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
EP0741709B1 (fr) * | 1994-01-24 | 2001-07-25 | Allergan Sales, Inc. | Derives aromatiques 2-amino-imidazole utilises comme agonistes de l'adrenorecepteur alpha-2a |
US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
HUP9904215A3 (en) * | 1996-11-25 | 2002-01-28 | Procter & Gamble | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-04-11 US US08/834,658 patent/US5866579A/en not_active Expired - Fee Related
-
1998
- 1998-04-10 WO PCT/US1998/007453 patent/WO1998046572A1/fr active IP Right Grant
- 1998-04-10 DE DE69830576T patent/DE69830576T2/de not_active Expired - Fee Related
- 1998-04-10 SI SI9830790T patent/SI0975602T1/sl unknown
- 1998-04-10 ES ES98915550T patent/ES2245029T3/es not_active Expired - Lifetime
- 1998-04-10 PT PT98915550T patent/PT975602E/pt unknown
- 1998-04-10 EP EP98915550A patent/EP0975602B1/fr not_active Expired - Lifetime
- 1998-04-10 DK DK98915550T patent/DK0975602T3/da active
- 1998-04-10 AU AU69705/98A patent/AU6970598A/en not_active Abandoned
- 1998-04-10 AT AT98915550T patent/ATE297899T1/de not_active IP Right Cessation
- 1998-10-20 US US09/175,253 patent/US6093727A/en not_active Expired - Fee Related
-
1999
- 1999-09-20 US US09/398,861 patent/US6294566B1/en not_active Expired - Fee Related
-
2000
- 2000-08-02 HK HK00104824A patent/HK1026892A1/xx not_active IP Right Cessation
-
2001
- 2001-08-20 US US09/933,106 patent/US6777426B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6777426B2 (en) | 2004-08-17 |
WO1998046572A1 (fr) | 1998-10-22 |
US6093727A (en) | 2000-07-25 |
AU6970598A (en) | 1998-11-11 |
US6294566B1 (en) | 2001-09-25 |
ES2245029T3 (es) | 2005-12-16 |
US5866579A (en) | 1999-02-02 |
EP0975602A1 (fr) | 2000-02-02 |
EP0975602A4 (fr) | 2003-01-22 |
DE69830576T2 (de) | 2006-05-04 |
EP0975602B1 (fr) | 2005-06-15 |
SI0975602T1 (sl) | 2005-12-31 |
HK1026892A1 (en) | 2000-12-29 |
ATE297899T1 (de) | 2005-07-15 |
DE69830576D1 (de) | 2005-07-21 |
PT975602E (pt) | 2005-10-31 |
US20020019390A1 (en) | 2002-02-14 |
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