DK0973895T3 - Transskriptionsfaktor Islet-Brain 1 (IB1) - Google Patents
Transskriptionsfaktor Islet-Brain 1 (IB1)Info
- Publication number
- DK0973895T3 DK0973895T3 DK98913958T DK98913958T DK0973895T3 DK 0973895 T3 DK0973895 T3 DK 0973895T3 DK 98913958 T DK98913958 T DK 98913958T DK 98913958 T DK98913958 T DK 98913958T DK 0973895 T3 DK0973895 T3 DK 0973895T3
- Authority
- DK
- Denmark
- Prior art keywords
- brain
- transcription factor
- glut2
- human
- disclosed
- Prior art date
Links
- 101710105206 C-Jun-amino-terminal kinase-interacting protein 1 Proteins 0.000 title abstract 4
- 102100022291 C-Jun-amino-terminal kinase-interacting protein 1 Human genes 0.000 title abstract 4
- 102000040945 Transcription factor Human genes 0.000 title 1
- 108091023040 Transcription factor Proteins 0.000 title 1
- 102000058058 Glucose Transporter Type 2 Human genes 0.000 abstract 2
- 101001046660 Homo sapiens C-Jun-amino-terminal kinase-interacting protein 1 Proteins 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 108091006299 SLC2A2 Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 101001046655 Rattus norvegicus C-Jun-amino-terminal kinase-interacting protein 1 Proteins 0.000 abstract 1
- 101100341613 Rattus norvegicus Mapk8ip1 gene Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000054579 human MAPK8IP1 Human genes 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108091006106 transcriptional activators Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9706731.8A GB9706731D0 (en) | 1997-04-03 | 1997-04-03 | Transcription factor islet-brain (IBI) |
| GBGB9709920.4A GB9709920D0 (en) | 1997-05-15 | 1997-05-15 | Transcription factor islet-brain 1 (B1) |
| PCT/GB1998/000972 WO1998044106A1 (fr) | 1997-04-03 | 1998-04-02 | Facteur de transcription ilot-cerveau 1 (ib1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0973895T3 true DK0973895T3 (da) | 2008-04-28 |
Family
ID=26311309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98913958T DK0973895T3 (da) | 1997-04-03 | 1998-04-02 | Transskriptionsfaktor Islet-Brain 1 (IB1) |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5880261A (fr) |
| EP (3) | EP1889913B1 (fr) |
| AT (2) | ATE517993T1 (fr) |
| AU (1) | AU6847298A (fr) |
| DE (1) | DE69838905T2 (fr) |
| DK (1) | DK0973895T3 (fr) |
| ES (1) | ES2299205T3 (fr) |
| PT (1) | PT973895E (fr) |
| WO (1) | WO1998044106A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043083A (en) * | 1997-04-28 | 2000-03-28 | Davis; Roger J. | Inhibitors of the JNK signal transduction pathway and methods of use |
| US20060019879A1 (en) * | 1998-07-31 | 2006-01-26 | El Shami A S | Polynucleotide encoding autoantigens associated with endometriosis |
| US20060019878A1 (en) * | 1998-07-31 | 2006-01-26 | El Shami A S | Polynucleotide encoding autoantigens associated with endometriosis |
| US6525187B1 (en) * | 1998-07-31 | 2003-02-25 | Diagnostic Products Corporation | Polynucleotide encoding autoantigens associated with endometriosis |
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US20030108539A1 (en) * | 2000-02-14 | 2003-06-12 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US6610820B1 (en) * | 1999-10-12 | 2003-08-26 | University Of Lausanne | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US6716824B1 (en) | 1999-10-22 | 2004-04-06 | F. Charles Brunicardi | Treatment of pancreatic adenocarcinoma by cytotoxic gene therapy |
| US7208581B1 (en) * | 1999-11-05 | 2007-04-24 | The Burnham Institute | TRAF family proteins |
| US6759197B2 (en) * | 2000-03-31 | 2004-07-06 | Sir Mortimer B. Davis -- Jewish General Hospital | Microchip arrays of regulatory genes |
| US6642003B2 (en) | 2001-08-02 | 2003-11-04 | Cedars-Sinai Medical Center | Human glucose-dependent insulin-secreting cell line |
| US7141240B2 (en) * | 2002-03-12 | 2006-11-28 | Cedars-Sinai Medical Center | Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1 |
| US20060223807A1 (en) | 2005-03-29 | 2006-10-05 | University Of Massachusetts Medical School, A Massachusetts Corporation | Therapeutic methods for type I diabetes |
| WO2007031098A1 (fr) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Inhibiteurs peptidiques permeables aux cellules de la voie de transduction de signal jnk |
| US8080517B2 (en) * | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| WO2009143865A1 (fr) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Utilisation d'inhibiteurs peptidiques des voies de traduction du signal jnk perméables aux cellules pour le traitement de diverses maladies |
| WO2009143864A1 (fr) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Utilisation d'inhibiteurs peptidiques perméables aux cellules de la voie de transduction du signal jnk pour le traitement de maladies digestives inflammatoires chroniques ou non chroniques |
| WO2010072228A1 (fr) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Nouvelles constructions transporteuses et molécules conjuguées cargo/transporteuses |
| JP5457813B2 (ja) * | 2009-12-16 | 2014-04-02 | ルネサスエレクトロニクス株式会社 | Ａｄｐｌｌ回路、半導体装置及び携帯情報機器 |
| WO2011160653A1 (fr) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Nouvelles molécules inhibant jnk |
| US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013091670A1 (fr) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Nouvelles molécules inhibitrices de jnk pour le traitement de diverses maladies |
| KR20160023669A (ko) | 2013-06-26 | 2016-03-03 | 자이겐 인플라메이션 리미티드 | 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도 |
| WO2014206427A1 (fr) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | Nouvelle utilisation d'inhibiteurs de peptides à perméabilité cellulaire dans la voie de transduction du signal jnk pour le traitement de diverses maladies |
| WO2015197097A1 (fr) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | Nouvelle utilisation pour des molécules inhibitrices de la jnk, pour le traitement de diverses maladies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0679716A4 (fr) * | 1993-11-12 | 1999-06-09 | Kenichi Matsubara | Signature genique. |
-
1997
- 1997-05-20 US US08/859,201 patent/US5880261A/en not_active Expired - Lifetime
-
1998
- 1998-04-02 DE DE69838905T patent/DE69838905T2/de not_active Expired - Lifetime
- 1998-04-02 AU AU68472/98A patent/AU6847298A/en not_active Abandoned
- 1998-04-02 PT PT98913958T patent/PT973895E/pt unknown
- 1998-04-02 US US09/402,214 patent/US6620914B1/en not_active Expired - Lifetime
- 1998-04-02 WO PCT/GB1998/000972 patent/WO1998044106A1/fr active IP Right Grant
- 1998-04-02 ES ES98913958T patent/ES2299205T3/es not_active Expired - Lifetime
- 1998-04-02 EP EP07019868A patent/EP1889913B1/fr not_active Expired - Lifetime
- 1998-04-02 DK DK98913958T patent/DK0973895T3/da active
- 1998-04-02 EP EP07008419A patent/EP1889912A1/fr not_active Withdrawn
- 1998-04-02 AT AT07019868T patent/ATE517993T1/de not_active IP Right Cessation
- 1998-04-02 EP EP98913958A patent/EP0973895B1/fr not_active Expired - Lifetime
- 1998-04-02 AT AT98913958T patent/ATE382087T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5880261A (en) | 1999-03-09 |
| EP1889913A1 (fr) | 2008-02-20 |
| EP1889912A1 (fr) | 2008-02-20 |
| ATE517993T1 (de) | 2011-08-15 |
| ATE382087T1 (de) | 2008-01-15 |
| DE69838905T2 (de) | 2008-12-11 |
| ES2299205T3 (es) | 2008-05-16 |
| EP0973895A1 (fr) | 2000-01-26 |
| WO1998044106A1 (fr) | 1998-10-08 |
| DE69838905D1 (de) | 2008-02-07 |
| EP1889913B1 (fr) | 2011-07-27 |
| EP0973895B1 (fr) | 2007-12-26 |
| US6620914B1 (en) | 2003-09-16 |
| AU6847298A (en) | 1998-10-22 |
| PT973895E (pt) | 2008-01-29 |
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