DK0966286T3 - Svækkelse af opioid-tolerance via inhibering af inducerbare nitrogenoxidsyntaseveje i smertebehandlingen - Google Patents
Svækkelse af opioid-tolerance via inhibering af inducerbare nitrogenoxidsyntaseveje i smertebehandlingenInfo
- Publication number
- DK0966286T3 DK0966286T3 DK98901665T DK98901665T DK0966286T3 DK 0966286 T3 DK0966286 T3 DK 0966286T3 DK 98901665 T DK98901665 T DK 98901665T DK 98901665 T DK98901665 T DK 98901665T DK 0966286 T3 DK0966286 T3 DK 0966286T3
- Authority
- DK
- Denmark
- Prior art keywords
- nitric oxide
- impairment
- inducible nitric
- oxide synthase
- pain management
- Prior art date
Links
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 title 1
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 title 1
- 230000006735 deficit Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Processing Of Meat And Fish (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Pyridine Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78181497A | 1997-01-09 | 1997-01-09 | |
| PCT/US1998/000006 WO1998030220A1 (en) | 1997-01-09 | 1998-01-06 | Attenuation of opioid tolerance by inhibiting inducible nitric oxide synthase pathways in the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0966286T3 true DK0966286T3 (da) | 2003-11-17 |
Family
ID=25124020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98901665T DK0966286T3 (da) | 1997-01-09 | 1998-01-06 | Svækkelse af opioid-tolerance via inhibering af inducerbare nitrogenoxidsyntaseveje i smertebehandlingen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0966286B1 (da) |
| JP (1) | JP2001508444A (da) |
| AT (1) | ATE245985T1 (da) |
| AU (1) | AU5813098A (da) |
| CA (1) | CA2272941A1 (da) |
| DE (1) | DE69816790T2 (da) |
| DK (1) | DK0966286T3 (da) |
| ES (1) | ES2205441T3 (da) |
| PT (1) | PT966286E (da) |
| WO (1) | WO1998030220A1 (da) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225440A (en) * | 1991-09-13 | 1993-07-06 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase |
| US5256669A (en) * | 1992-08-07 | 1993-10-26 | Aminotek Sciences, Inc. | Methods and compositions for treating acute or chronic pain and drug addiction |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| CA2115792C (en) * | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
| DK0724435T3 (da) * | 1993-10-21 | 2002-11-25 | Searle & Co | Amidinoderivater, der er nyttige som nitrogenoxid-synthase-inhibitorer |
| US5726156A (en) * | 1995-03-06 | 1998-03-10 | Trega Biosciences, Inc. | Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| PT749418E (pt) * | 1994-03-10 | 2001-01-31 | Searle & Co | Derivados de l-n6-(1-iminoetil)lisina uteis como inibidores de oxido nitrico sintetase |
| DE4442116A1 (de) * | 1994-11-25 | 1996-05-30 | Cassella Ag | 2-Amino-1,3-thiazine als Hemmstoffe der Stickstoffmonoxid-Synthase |
| WO1996018616A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| GB9425701D0 (en) * | 1994-12-20 | 1995-02-22 | Wellcome Found | Enzyme inhibitors |
| CN1190390A (zh) * | 1995-05-10 | 1998-08-12 | G.D.瑟尔公司 | 由环状脒衍生的氧化氮合成酶抑制剂 |
-
1998
- 1998-01-06 DK DK98901665T patent/DK0966286T3/da active
- 1998-01-06 PT PT98901665T patent/PT966286E/pt unknown
- 1998-01-06 DE DE69816790T patent/DE69816790T2/de not_active Expired - Fee Related
- 1998-01-06 CA CA002272941A patent/CA2272941A1/en not_active Abandoned
- 1998-01-06 AU AU58130/98A patent/AU5813098A/en not_active Abandoned
- 1998-01-06 ES ES98901665T patent/ES2205441T3/es not_active Expired - Lifetime
- 1998-01-06 AT AT98901665T patent/ATE245985T1/de not_active IP Right Cessation
- 1998-01-06 EP EP98901665A patent/EP0966286B1/en not_active Expired - Lifetime
- 1998-01-06 JP JP53096198A patent/JP2001508444A/ja not_active Abandoned
- 1998-01-06 WO PCT/US1998/000006 patent/WO1998030220A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69816790D1 (de) | 2003-09-04 |
| PT966286E (pt) | 2003-12-31 |
| WO1998030220A1 (en) | 1998-07-16 |
| JP2001508444A (ja) | 2001-06-26 |
| EP0966286B1 (en) | 2003-07-30 |
| ES2205441T3 (es) | 2004-05-01 |
| ATE245985T1 (de) | 2003-08-15 |
| EP0966286A1 (en) | 1999-12-29 |
| AU5813098A (en) | 1998-08-03 |
| CA2272941A1 (en) | 1998-07-16 |
| DE69816790T2 (de) | 2004-04-22 |
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