ATE232544T1 - Selektive inhibitoren des mmp-12 - Google Patents

Selektive inhibitoren des mmp-12

Info

Publication number
ATE232544T1
ATE232544T1 AT99960295T AT99960295T ATE232544T1 AT E232544 T1 ATE232544 T1 AT E232544T1 AT 99960295 T AT99960295 T AT 99960295T AT 99960295 T AT99960295 T AT 99960295T AT E232544 T1 ATE232544 T1 AT E232544T1
Authority
AT
Austria
Prior art keywords
mmp
selective inhibitors
inhibitors
selective
Prior art date
Application number
AT99960295T
Other languages
English (en)
Inventor
Alan M Warshawsky
Michael J Janusz
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE232544T1 publication Critical patent/ATE232544T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99960295T 1998-12-31 1999-11-12 Selektive inhibitoren des mmp-12 ATE232544T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22455098A 1998-12-31 1998-12-31
PCT/US1999/026749 WO2000040600A1 (en) 1998-12-31 1999-11-12 Selective inhibitors of mmp-12

Publications (1)

Publication Number Publication Date
ATE232544T1 true ATE232544T1 (de) 2003-02-15

Family

ID=22841172

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99960295T ATE232544T1 (de) 1998-12-31 1999-11-12 Selektive inhibitoren des mmp-12

Country Status (10)

Country Link
EP (1) EP1140984B1 (de)
JP (1) JP2002534435A (de)
AR (1) AR022170A1 (de)
AT (1) ATE232544T1 (de)
AU (1) AU1719700A (de)
CA (1) CA2356919A1 (de)
DE (1) DE69905397T2 (de)
DK (1) DK1140984T3 (de)
ES (1) ES2188277T3 (de)
WO (1) WO2000040600A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777443B2 (en) 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
EP1394159A1 (de) * 2002-08-13 2004-03-03 Warner-Lambert Company LLC Neue Thiophen-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP2907512A1 (de) 2014-02-14 2015-08-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Hemmer von MMP-12 als antivirale Wirkstoffe

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69795A (en) * 1983-09-23 1987-01-30 Univ Ramot Ophthalmic preparations containing as active ingredient 2-mercaptoalkanoyl peptides
GB9607120D0 (en) * 1996-04-04 1996-06-12 Chiroscience Ltd Compounds
GB9615976D0 (en) * 1996-07-30 1996-09-11 Center For Clinical & Basic Re The use of proteinase inhibitors for the prevention or reduction of bone resorption
HUP0101300A3 (en) * 1998-01-09 2002-11-28 Pfizer Matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
AR022170A1 (es) 2002-09-04
AU1719700A (en) 2000-07-24
EP1140984A1 (de) 2001-10-10
DE69905397T2 (de) 2003-12-18
EP1140984B1 (de) 2003-02-12
WO2000040600A1 (en) 2000-07-13
ES2188277T3 (es) 2003-06-16
JP2002534435A (ja) 2002-10-15
DK1140984T3 (da) 2003-05-26
DE69905397D1 (de) 2003-03-20
CA2356919A1 (en) 2000-07-13

Similar Documents

Publication Publication Date Title
ATE410439T1 (de) Caspase inhibitoren
PT1114051E (pt) Inibidores de p38
IS5711A (is) Heteróhringatálmar við P38
NO20004550D0 (no) Enzyminhibitorer
DE60020259D1 (de) C-aryl-glucosid-sglt2-inhibitoren
NO20012980L (no) Proteaseinhibitorer
DE69716615D1 (de) Heterozyklische metalloproteaseinhibitoren
PT958287E (pt) Inibidores de sulfamida-metaloprotease
DE59806475D1 (de) Urokinase-inhibitoren
NO20003814L (no) Trombininhibitorer
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
NO20010660D0 (no) Isolator
ID28032A (id) TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2
NO20010085D0 (no) Angiogeneseinhibitorer
ATE225346T1 (de) Fkbp inhibitoren
DE69903507D1 (de) Beizvorrichtung
MA24877A1 (fr) INHIBITEURS DE PROTéASES
ATE232544T1 (de) Selektive inhibitoren des mmp-12
DE69901764D1 (de) Beizvorrichtung
PT1272456E (pt) Inibidores de angiogenese de hidrazida e alcoxiamida
DE59908053D1 (de) Eingehauste Beizanlage
NO993161L (no) Cyklooksygenaseinhibitor
NO20006314D0 (no) Prenyltransferase-inhibitorer
DK2277920T3 (da) Komplementaktiveringsinhibitorer
FI980245A0 (fi) Vaegvisningssystem foer noedsituationer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1140984

Country of ref document: EP

REN Ceased due to non-payment of the annual fee